The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells

Transcription factor (TF) networks are essential for the molecular identity of each cell type. Here, the authors show that TF Nanog utilises multiple molecular strategies to enhance embryonic stem cell self-renewal, which include regulation of chromatin accessibility in the presence of LIF or mainte...

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Autores principales:	Victor Heurtier, Nick Owens, Inma Gonzalez, Florian Mueller, Caroline Proux, Damien Mornico, Philippe Clerc, Agnes Dubois, Pablo Navarro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bba6964391024d328a208f5b723bf1fc
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spelling	oai:doaj.org-article:bba6964391024d328a208f5b723bf1fc2021-12-02T15:36:03ZThe molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells10.1038/s41467-019-09041-z2041-1723https://doaj.org/article/bba6964391024d328a208f5b723bf1fc2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09041-zhttps://doaj.org/toc/2041-1723Transcription factor (TF) networks are essential for the molecular identity of each cell type. Here, the authors show that TF Nanog utilises multiple molecular strategies to enhance embryonic stem cell self-renewal, which include regulation of chromatin accessibility in the presence of LIF or maintenance of H3K27me3 at developmental regulators in its absence.Victor HeurtierNick OwensInma GonzalezFlorian MuellerCaroline ProuxDamien MornicoPhilippe ClercAgnes DuboisPablo NavarroNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Victor Heurtier Nick Owens Inma Gonzalez Florian Mueller Caroline Proux Damien Mornico Philippe Clerc Agnes Dubois Pablo Navarro The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells
description	Transcription factor (TF) networks are essential for the molecular identity of each cell type. Here, the authors show that TF Nanog utilises multiple molecular strategies to enhance embryonic stem cell self-renewal, which include regulation of chromatin accessibility in the presence of LIF or maintenance of H3K27me3 at developmental regulators in its absence.
format	article
author	Victor Heurtier Nick Owens Inma Gonzalez Florian Mueller Caroline Proux Damien Mornico Philippe Clerc Agnes Dubois Pablo Navarro
author_facet	Victor Heurtier Nick Owens Inma Gonzalez Florian Mueller Caroline Proux Damien Mornico Philippe Clerc Agnes Dubois Pablo Navarro
author_sort	Victor Heurtier
title	The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells
title_short	The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells
title_full	The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells
title_fullStr	The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells
title_full_unstemmed	The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells
title_sort	molecular logic of nanog-induced self-renewal in mouse embryonic stem cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bba6964391024d328a208f5b723bf1fc
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The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells

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