Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization,  natural biodistribution, and acute toxicity

Michael M Galagudza1, Dmitry V Korolev1, Dmitry L Sonin1, Viktor N Postnov2, Garry V Papayan3, Ivan S Uskov1, Anastasia V Belozertseva1, Eugene V Shlyakhto11Institute of Experimental Medicine, VA. Almazov Federal Heart, Blood and Endocrinology Center, St-Petersburg, Russian Federation; 2Chemical Fac...

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Autores principales: Michael M Galagudza, Dmitry V Korolev, Dmitry L Sonin, et al
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Lenguaje:EN
Publicado: Dove Medical Press 2010
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Acceso en línea:https://doaj.org/article/bba6c45bf6d24d23bf509a8974798753
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spelling oai:doaj.org-article:bba6c45bf6d24d23bf509a89747987532021-12-02T05:17:40ZTargeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization,  natural biodistribution, and acute toxicity1176-91141178-2013https://doaj.org/article/bba6c45bf6d24d23bf509a89747987532010-03-01T00:00:00Zhttp://www.dovepress.com/targeted-drug-delivery-into-reversibly-injured-myocardium-with-silica--a4136https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Michael M Galagudza1, Dmitry V Korolev1, Dmitry L Sonin1, Viktor N Postnov2, Garry V Papayan3, Ivan S Uskov1, Anastasia V Belozertseva1, Eugene V Shlyakhto11Institute of Experimental Medicine, VA. Almazov Federal Heart, Blood and Endocrinology Center, St-Petersburg, Russian Federation; 2Chemical Faculty, St-Petersburg State University, St-Petersburg, Russian Federation;  3Department of Pathophysiology, IP. Pavlov State Medical University, St-Petersburg, Russian FederationAbstract: The clinical outcome of patients with ischemic heart disease can be significantly improved with the implementation of targeted drug delivery into the ischemic myocardium. In this paper, we present our original findings relevant to the problem of therapeutic heart targeting with use of nanoparticles. Experimental approaches included fabrication of carbon and silica nanoparticles, their characterization and surface modification. The acute hemodynamic effects of nanoparticle formulation as well as nanoparticle biodistribution were studied in male Wistar rats. Carbon and silica nanoparticles are non-toxic materials that can be used as carriers for heart-targeted drug delivery. Concepts of passive and active targeting can be applied to the development of targeted drug delivery to the ischemic myocardial cells. Provided that ischemic heart-targeted drug delivery can be proved to be safe and efficient, the results of this research may contribute to the development of new technologies in the pharmaceutical industry.Keywords: nanocarriers, targeted drug delivery, myocardial ischemia Michael M GalagudzaDmitry V KorolevDmitry L Soninet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 231-237 (2010)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Michael M Galagudza
Dmitry V Korolev
Dmitry L Sonin
et al
Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization,  natural biodistribution, and acute toxicity
description Michael M Galagudza1, Dmitry V Korolev1, Dmitry L Sonin1, Viktor N Postnov2, Garry V Papayan3, Ivan S Uskov1, Anastasia V Belozertseva1, Eugene V Shlyakhto11Institute of Experimental Medicine, VA. Almazov Federal Heart, Blood and Endocrinology Center, St-Petersburg, Russian Federation; 2Chemical Faculty, St-Petersburg State University, St-Petersburg, Russian Federation;  3Department of Pathophysiology, IP. Pavlov State Medical University, St-Petersburg, Russian FederationAbstract: The clinical outcome of patients with ischemic heart disease can be significantly improved with the implementation of targeted drug delivery into the ischemic myocardium. In this paper, we present our original findings relevant to the problem of therapeutic heart targeting with use of nanoparticles. Experimental approaches included fabrication of carbon and silica nanoparticles, their characterization and surface modification. The acute hemodynamic effects of nanoparticle formulation as well as nanoparticle biodistribution were studied in male Wistar rats. Carbon and silica nanoparticles are non-toxic materials that can be used as carriers for heart-targeted drug delivery. Concepts of passive and active targeting can be applied to the development of targeted drug delivery to the ischemic myocardial cells. Provided that ischemic heart-targeted drug delivery can be proved to be safe and efficient, the results of this research may contribute to the development of new technologies in the pharmaceutical industry.Keywords: nanocarriers, targeted drug delivery, myocardial ischemia
format article
author Michael M Galagudza
Dmitry V Korolev
Dmitry L Sonin
et al
author_facet Michael M Galagudza
Dmitry V Korolev
Dmitry L Sonin
et al
author_sort Michael M Galagudza
title Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization,  natural biodistribution, and acute toxicity
title_short Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization,  natural biodistribution, and acute toxicity
title_full Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization,  natural biodistribution, and acute toxicity
title_fullStr Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization,  natural biodistribution, and acute toxicity
title_full_unstemmed Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization,  natural biodistribution, and acute toxicity
title_sort targeted drug delivery into reversibly injured myocardium with silica nanoparticles: surface functionalization,  natural biodistribution, and acute toxicity
publisher Dove Medical Press
publishDate 2010
url https://doaj.org/article/bba6c45bf6d24d23bf509a8974798753
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AT dmitryvkorolev targeteddrugdeliveryintoreversiblyinjuredmyocardiumwithsilicananoparticlessurfacefunctionalizationampnbspnaturalbiodistributionandacutetoxicity
AT dmitrylsonin targeteddrugdeliveryintoreversiblyinjuredmyocardiumwithsilicananoparticlessurfacefunctionalizationampnbspnaturalbiodistributionandacutetoxicity
AT etal targeteddrugdeliveryintoreversiblyinjuredmyocardiumwithsilicananoparticlessurfacefunctionalizationampnbspnaturalbiodistributionandacutetoxicity
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