Significant low prevalence of antibodies reacting with simian virus 40 mimotopes in serum samples from patients affected by inflammatory neurologic diseases, including multiple sclerosis.

Many investigations were carried out on the association between viruses and multiple sclerosis (MS). Indeed, early studies reported the detections of neurotropic virus footprints in the CNS of patients with MS. In this study, sera from patients affected by MS, other inflammatory (OIND) and non-infla...

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Autores principales:	Elisa Mazzoni, Silvia Pietrobon, Irene Masini, John Charles Rotondo, Mauro Gentile, Enrico Fainardi, Ilaria Casetta, Massimiliano Castellazzi, Enrico Granieri, Maria Luisa Caniati, Maria Rosaria Tola, Giovanni Guerra, Fernanda Martini, Mauro Tognon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bbab2c74d89a448ab500aa11ca06e7cb
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spelling	oai:doaj.org-article:bbab2c74d89a448ab500aa11ca06e7cb2021-11-25T05:54:48ZSignificant low prevalence of antibodies reacting with simian virus 40 mimotopes in serum samples from patients affected by inflammatory neurologic diseases, including multiple sclerosis.1932-620310.1371/journal.pone.0110923https://doaj.org/article/bbab2c74d89a448ab500aa11ca06e7cb2014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0110923https://doaj.org/toc/1932-6203Many investigations were carried out on the association between viruses and multiple sclerosis (MS). Indeed, early studies reported the detections of neurotropic virus footprints in the CNS of patients with MS. In this study, sera from patients affected by MS, other inflammatory (OIND) and non-inflammatory neurologic diseases (NIND) were analyzed for antibodies against the polyomavirus, Simian Virus 40 (SV40). An indirect enzyme-linked immunosorbent assay (ELISA), with two synthetic peptides, which mimic SV40 antigens, was employed to detect specific antibodies in sera from patients affected by MS, OIND, NIND and healthy subjects (HS). Immunologic data indicate that in sera from MS patients antibodies against SV40 mimotopes are detectable with a low prevalence, 6%, whereas in HS of the same mean age, 40 yrs, the prevalence was 22%. The difference is statistically significant (P = 0.001). Significant is also the difference between MS vs. NIND patients (6% vs. 17%; P = 0.0254), whereas no significant difference was detected between MS vs OIND (6% vs 10%; P>0.05). The prevalence of SV40 antibodies in MS patients is 70% lower than that revealed in HS.Elisa MazzoniSilvia PietrobonIrene MasiniJohn Charles RotondoMauro GentileEnrico FainardiIlaria CasettaMassimiliano CastellazziEnrico GranieriMaria Luisa CaniatiMaria Rosaria TolaGiovanni GuerraFernanda MartiniMauro TognonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 11, p e110923 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elisa Mazzoni Silvia Pietrobon Irene Masini John Charles Rotondo Mauro Gentile Enrico Fainardi Ilaria Casetta Massimiliano Castellazzi Enrico Granieri Maria Luisa Caniati Maria Rosaria Tola Giovanni Guerra Fernanda Martini Mauro Tognon Significant low prevalence of antibodies reacting with simian virus 40 mimotopes in serum samples from patients affected by inflammatory neurologic diseases, including multiple sclerosis.
description	Many investigations were carried out on the association between viruses and multiple sclerosis (MS). Indeed, early studies reported the detections of neurotropic virus footprints in the CNS of patients with MS. In this study, sera from patients affected by MS, other inflammatory (OIND) and non-inflammatory neurologic diseases (NIND) were analyzed for antibodies against the polyomavirus, Simian Virus 40 (SV40). An indirect enzyme-linked immunosorbent assay (ELISA), with two synthetic peptides, which mimic SV40 antigens, was employed to detect specific antibodies in sera from patients affected by MS, OIND, NIND and healthy subjects (HS). Immunologic data indicate that in sera from MS patients antibodies against SV40 mimotopes are detectable with a low prevalence, 6%, whereas in HS of the same mean age, 40 yrs, the prevalence was 22%. The difference is statistically significant (P = 0.001). Significant is also the difference between MS vs. NIND patients (6% vs. 17%; P = 0.0254), whereas no significant difference was detected between MS vs OIND (6% vs 10%; P>0.05). The prevalence of SV40 antibodies in MS patients is 70% lower than that revealed in HS.
format	article
author	Elisa Mazzoni Silvia Pietrobon Irene Masini John Charles Rotondo Mauro Gentile Enrico Fainardi Ilaria Casetta Massimiliano Castellazzi Enrico Granieri Maria Luisa Caniati Maria Rosaria Tola Giovanni Guerra Fernanda Martini Mauro Tognon
author_facet	Elisa Mazzoni Silvia Pietrobon Irene Masini John Charles Rotondo Mauro Gentile Enrico Fainardi Ilaria Casetta Massimiliano Castellazzi Enrico Granieri Maria Luisa Caniati Maria Rosaria Tola Giovanni Guerra Fernanda Martini Mauro Tognon
author_sort	Elisa Mazzoni
title	Significant low prevalence of antibodies reacting with simian virus 40 mimotopes in serum samples from patients affected by inflammatory neurologic diseases, including multiple sclerosis.
title_short	Significant low prevalence of antibodies reacting with simian virus 40 mimotopes in serum samples from patients affected by inflammatory neurologic diseases, including multiple sclerosis.
title_full	Significant low prevalence of antibodies reacting with simian virus 40 mimotopes in serum samples from patients affected by inflammatory neurologic diseases, including multiple sclerosis.
title_fullStr	Significant low prevalence of antibodies reacting with simian virus 40 mimotopes in serum samples from patients affected by inflammatory neurologic diseases, including multiple sclerosis.
title_full_unstemmed	Significant low prevalence of antibodies reacting with simian virus 40 mimotopes in serum samples from patients affected by inflammatory neurologic diseases, including multiple sclerosis.
title_sort	significant low prevalence of antibodies reacting with simian virus 40 mimotopes in serum samples from patients affected by inflammatory neurologic diseases, including multiple sclerosis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/bbab2c74d89a448ab500aa11ca06e7cb
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Significant low prevalence of antibodies reacting with simian virus 40 mimotopes in serum samples from patients affected by inflammatory neurologic diseases, including multiple sclerosis.

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