Outcome measures for assessing change over time in studies of symptomatic children with hypermobility: a systematic review

Abstract Background Generalised joint hypermobility (GJH) is highly prevalent among children and associated with symptoms in a fifth with the condition. This study aimed to synthesise outcome measures in interventional or prospective longitudinal studies of children with GJH and associated lower lim...

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Autores principales:	Muhammad Maarj, Andrea Coda, Louise Tofts, Cylie Williams, Derek Santos, Verity Pacey
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Fatigue Outcome measures Paediatrics Hypermobility Pain Function Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/bbababe115d344ad8ff772ac73cbf9d6
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spelling	oai:doaj.org-article:bbababe115d344ad8ff772ac73cbf9d62021-12-05T12:21:12ZOutcome measures for assessing change over time in studies of symptomatic children with hypermobility: a systematic review10.1186/s12887-021-03009-z1471-2431https://doaj.org/article/bbababe115d344ad8ff772ac73cbf9d62021-11-01T00:00:00Zhttps://doi.org/10.1186/s12887-021-03009-zhttps://doaj.org/toc/1471-2431Abstract Background Generalised joint hypermobility (GJH) is highly prevalent among children and associated with symptoms in a fifth with the condition. This study aimed to synthesise outcome measures in interventional or prospective longitudinal studies of children with GJH and associated lower limb symptoms. Methods Electronic searches of Medline, CINAHL and Embase databases from inception to 16th March 2020 were performed for studies of children with GJH and symptoms between 5 and 18 years reporting repeated outcome measures collected at least 4 weeks apart. Methodological quality of eligible studies were described using the Downs and Black checklist. Results Six studies comprising of five interventional, and one prospective observational study (total of 388 children) met the inclusion criteria. Interventional study durations were between 2 and 3 months, with up to 10 months post-intervention follow-up, while the observational study spanned 3 years. Three main constructs of pain, function and quality of life were reported as primary outcome measures using 20 different instruments. All but one measure was validated in paediatric populations, but not specifically for children with GJH and symptoms. One study assessed fatigue, reporting disabling fatigue to be associated with higher pain intensity. Conclusions There were no agreed sets of outcome measures used for children with GJH and symptoms. The standardisation of assessment tools across paediatric clinical trials is needed. Four constructs of pain, function, quality of life and fatigue are recommended to be included with agreed upon, validated, objective tools.Muhammad MaarjAndrea CodaLouise ToftsCylie WilliamsDerek SantosVerity PaceyBMCarticleFatigueOutcome measuresPaediatricsHypermobilityPainFunctionPediatricsRJ1-570ENBMC Pediatrics, Vol 21, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fatigue Outcome measures Paediatrics Hypermobility Pain Function Pediatrics RJ1-570
spellingShingle	Fatigue Outcome measures Paediatrics Hypermobility Pain Function Pediatrics RJ1-570 Muhammad Maarj Andrea Coda Louise Tofts Cylie Williams Derek Santos Verity Pacey Outcome measures for assessing change over time in studies of symptomatic children with hypermobility: a systematic review
description	Abstract Background Generalised joint hypermobility (GJH) is highly prevalent among children and associated with symptoms in a fifth with the condition. This study aimed to synthesise outcome measures in interventional or prospective longitudinal studies of children with GJH and associated lower limb symptoms. Methods Electronic searches of Medline, CINAHL and Embase databases from inception to 16th March 2020 were performed for studies of children with GJH and symptoms between 5 and 18 years reporting repeated outcome measures collected at least 4 weeks apart. Methodological quality of eligible studies were described using the Downs and Black checklist. Results Six studies comprising of five interventional, and one prospective observational study (total of 388 children) met the inclusion criteria. Interventional study durations were between 2 and 3 months, with up to 10 months post-intervention follow-up, while the observational study spanned 3 years. Three main constructs of pain, function and quality of life were reported as primary outcome measures using 20 different instruments. All but one measure was validated in paediatric populations, but not specifically for children with GJH and symptoms. One study assessed fatigue, reporting disabling fatigue to be associated with higher pain intensity. Conclusions There were no agreed sets of outcome measures used for children with GJH and symptoms. The standardisation of assessment tools across paediatric clinical trials is needed. Four constructs of pain, function, quality of life and fatigue are recommended to be included with agreed upon, validated, objective tools.
format	article
author	Muhammad Maarj Andrea Coda Louise Tofts Cylie Williams Derek Santos Verity Pacey
author_facet	Muhammad Maarj Andrea Coda Louise Tofts Cylie Williams Derek Santos Verity Pacey
author_sort	Muhammad Maarj
title	Outcome measures for assessing change over time in studies of symptomatic children with hypermobility: a systematic review
title_short	Outcome measures for assessing change over time in studies of symptomatic children with hypermobility: a systematic review
title_full	Outcome measures for assessing change over time in studies of symptomatic children with hypermobility: a systematic review
title_fullStr	Outcome measures for assessing change over time in studies of symptomatic children with hypermobility: a systematic review
title_full_unstemmed	Outcome measures for assessing change over time in studies of symptomatic children with hypermobility: a systematic review
title_sort	outcome measures for assessing change over time in studies of symptomatic children with hypermobility: a systematic review
publisher	BMC
publishDate	2021
url	https://doaj.org/article/bbababe115d344ad8ff772ac73cbf9d6
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Outcome measures for assessing change over time in studies of symptomatic children with hypermobility: a systematic review

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