Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity

Type I interferon drives autoimmune pathology in SLE and has been assumed to come predominantly from plasmacytoid dendritic cells (pDCs). Here, the authors show that prior to the onset of SLE, pDCs lose multiple immunogenic functions and, instead, non-hematopoietic cells such as keratinocytes are a...

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Autores principales:	Antonios Psarras, Adewonuola Alase, Agne Antanaviciute, Ian M. Carr, Md Yuzaiful Md Yusof, Miriam Wittmann, Paul Emery, George C. Tsokos, Edward M. Vital
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bbb2318833484129bd8e0fdec78640c3
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spelling	oai:doaj.org-article:bbb2318833484129bd8e0fdec78640c32021-12-02T17:32:43ZFunctionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity10.1038/s41467-020-19918-z2041-1723https://doaj.org/article/bbb2318833484129bd8e0fdec78640c32020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19918-zhttps://doaj.org/toc/2041-1723Type I interferon drives autoimmune pathology in SLE and has been assumed to come predominantly from plasmacytoid dendritic cells (pDCs). Here, the authors show that prior to the onset of SLE, pDCs lose multiple immunogenic functions and, instead, non-hematopoietic cells such as keratinocytes are a major source of type I interferons.Antonios PsarrasAdewonuola AlaseAgne AntanaviciuteIan M. CarrMd Yuzaiful Md YusofMiriam WittmannPaul EmeryGeorge C. TsokosEdward M. VitalNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Antonios Psarras Adewonuola Alase Agne Antanaviciute Ian M. Carr Md Yuzaiful Md Yusof Miriam Wittmann Paul Emery George C. Tsokos Edward M. Vital Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity
description	Type I interferon drives autoimmune pathology in SLE and has been assumed to come predominantly from plasmacytoid dendritic cells (pDCs). Here, the authors show that prior to the onset of SLE, pDCs lose multiple immunogenic functions and, instead, non-hematopoietic cells such as keratinocytes are a major source of type I interferons.
format	article
author	Antonios Psarras Adewonuola Alase Agne Antanaviciute Ian M. Carr Md Yuzaiful Md Yusof Miriam Wittmann Paul Emery George C. Tsokos Edward M. Vital
author_facet	Antonios Psarras Adewonuola Alase Agne Antanaviciute Ian M. Carr Md Yuzaiful Md Yusof Miriam Wittmann Paul Emery George C. Tsokos Edward M. Vital
author_sort	Antonios Psarras
title	Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity
title_short	Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity
title_full	Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity
title_fullStr	Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity
title_full_unstemmed	Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity
title_sort	functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type i interferon characterize human autoimmunity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bbb2318833484129bd8e0fdec78640c3
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Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity

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