Changes of immune cells in patients with hepatocellular carcinoma treated by radiofrequency ablation and hepatectomy, a pilot study

In this pilot study, we compared the dynamic changes of circulating immune cells between patients with hepatocellular carcinoma (HCC) who underwent radiofrequency ablation (RFA) and hepatectomy. Seventy-three patients were enrolled in this study. Flow cytometry assay was performed to determine the i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yu Zusheng, Li Guowei, Yu Hang, Asakawa Tetsuya
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	small hcc rfa hepatectomy immune cells pbmcs Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bbb55f3e1ceb47a89c3f42a1d83b4c38
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bbb55f3e1ceb47a89c3f42a1d83b4c38
record_format	dspace
spelling	oai:doaj.org-article:bbb55f3e1ceb47a89c3f42a1d83b4c382021-12-05T14:10:41ZChanges of immune cells in patients with hepatocellular carcinoma treated by radiofrequency ablation and hepatectomy, a pilot study2391-541210.1515/biol-2021-0105https://doaj.org/article/bbb55f3e1ceb47a89c3f42a1d83b4c382021-09-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0105https://doaj.org/toc/2391-5412In this pilot study, we compared the dynamic changes of circulating immune cells between patients with hepatocellular carcinoma (HCC) who underwent radiofrequency ablation (RFA) and hepatectomy. Seventy-three patients were enrolled in this study. Flow cytometry assay was performed to determine the immune cells in the peripheral blood mononuclear cells (PBMCs) before treatment and on days 7, 14, and 28 after treatment. We found that in the RFA group, the circulating cluster of differentiation (CD)4+ cells, the CD4+/CD8+ ratio, and natural killer (NK) cells continued to increase, and the circulating CD8+ cells continued to decrease after the treatment. In contrast, in the surgery group, the circulating CD4+ cells and CD4+/CD8+ ratio decreased over the first seven postoperative days and then began to increase, and CD8+ cells decreased on the first 7 postoperative days and began to increase thereafter. The changes of immune cells in tumor tissues consisted of an increase in the number of CD4+ cells, CD8+ cells, CD3+ cells, and NK cells immediately after RFA. Our results show that postoperative immune function continued to improve after RFA, but after surgery, it decreased in the first week and started to improve thereafter. These findings are important for clinicians when selecting the appropriate therapy for HCC.Yu ZushengLi GuoweiYu HangAsakawa TetsuyaDe Gruyterarticlesmall hccrfahepatectomyimmune cellspbmcsBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 1002-1009 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	small hcc rfa hepatectomy immune cells pbmcs Biology (General) QH301-705.5
spellingShingle	small hcc rfa hepatectomy immune cells pbmcs Biology (General) QH301-705.5 Yu Zusheng Li Guowei Yu Hang Asakawa Tetsuya Changes of immune cells in patients with hepatocellular carcinoma treated by radiofrequency ablation and hepatectomy, a pilot study
description	In this pilot study, we compared the dynamic changes of circulating immune cells between patients with hepatocellular carcinoma (HCC) who underwent radiofrequency ablation (RFA) and hepatectomy. Seventy-three patients were enrolled in this study. Flow cytometry assay was performed to determine the immune cells in the peripheral blood mononuclear cells (PBMCs) before treatment and on days 7, 14, and 28 after treatment. We found that in the RFA group, the circulating cluster of differentiation (CD)4+ cells, the CD4+/CD8+ ratio, and natural killer (NK) cells continued to increase, and the circulating CD8+ cells continued to decrease after the treatment. In contrast, in the surgery group, the circulating CD4+ cells and CD4+/CD8+ ratio decreased over the first seven postoperative days and then began to increase, and CD8+ cells decreased on the first 7 postoperative days and began to increase thereafter. The changes of immune cells in tumor tissues consisted of an increase in the number of CD4+ cells, CD8+ cells, CD3+ cells, and NK cells immediately after RFA. Our results show that postoperative immune function continued to improve after RFA, but after surgery, it decreased in the first week and started to improve thereafter. These findings are important for clinicians when selecting the appropriate therapy for HCC.
format	article
author	Yu Zusheng Li Guowei Yu Hang Asakawa Tetsuya
author_facet	Yu Zusheng Li Guowei Yu Hang Asakawa Tetsuya
author_sort	Yu Zusheng
title	Changes of immune cells in patients with hepatocellular carcinoma treated by radiofrequency ablation and hepatectomy, a pilot study
title_short	Changes of immune cells in patients with hepatocellular carcinoma treated by radiofrequency ablation and hepatectomy, a pilot study
title_full	Changes of immune cells in patients with hepatocellular carcinoma treated by radiofrequency ablation and hepatectomy, a pilot study
title_fullStr	Changes of immune cells in patients with hepatocellular carcinoma treated by radiofrequency ablation and hepatectomy, a pilot study
title_full_unstemmed	Changes of immune cells in patients with hepatocellular carcinoma treated by radiofrequency ablation and hepatectomy, a pilot study
title_sort	changes of immune cells in patients with hepatocellular carcinoma treated by radiofrequency ablation and hepatectomy, a pilot study
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/bbb55f3e1ceb47a89c3f42a1d83b4c38
work_keys_str_mv	AT yuzusheng changesofimmunecellsinpatientswithhepatocellularcarcinomatreatedbyradiofrequencyablationandhepatectomyapilotstudy AT liguowei changesofimmunecellsinpatientswithhepatocellularcarcinomatreatedbyradiofrequencyablationandhepatectomyapilotstudy AT yuhang changesofimmunecellsinpatientswithhepatocellularcarcinomatreatedbyradiofrequencyablationandhepatectomyapilotstudy AT asakawatetsuya changesofimmunecellsinpatientswithhepatocellularcarcinomatreatedbyradiofrequencyablationandhepatectomyapilotstudy
_version_	1718371862669426688

Changes of immune cells in patients with hepatocellular carcinoma treated by radiofrequency ablation and hepatectomy, a pilot study

Ejemplares similares