Clinical features and imaging findings in a case of Capgras syndrome

Maria Luca,1 Andrea Bordone,1 Antonina Luca,2 Andrea Patti,1 Giuseppe Sortino,3 Carmela Calandra11Department of Medical and Surgery Specialties, Psychiatry Unit, 2Department GF Ingrassia, Section of Neuroscience, 3Department of Diagnostic Imaging, Radiology Unit, University Hospital Policlinico-Vitt...

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Autores principales:	Luca M, Bordone A, Luca A, Patti A, Sortino G, Calandra C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/bbb6b5e07f604aa0a7e24cce568cc9e6
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spelling	oai:doaj.org-article:bbb6b5e07f604aa0a7e24cce568cc9e62021-12-02T06:32:15ZClinical features and imaging findings in a case of Capgras syndrome1176-63281178-2021https://doaj.org/article/bbb6b5e07f604aa0a7e24cce568cc9e62013-08-01T00:00:00Zhttp://www.dovepress.com/clinical-features-and-imaging-findings-in-a-case-of-capgras-syndrome-a13919https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Maria Luca,1 Andrea Bordone,1 Antonina Luca,2 Andrea Patti,1 Giuseppe Sortino,3 Carmela Calandra11Department of Medical and Surgery Specialties, Psychiatry Unit, 2Department GF Ingrassia, Section of Neuroscience, 3Department of Diagnostic Imaging, Radiology Unit, University Hospital Policlinico-Vittorio Emanuele, Catania, Sicily, ItalyAbstract: Capgras syndrome consists of the delusional belief that a person or persons have been replaced by doubles or impostors. It can occur in the context of both psychiatric and organic illness, and seems to be related to lesions of the bifrontal and right limbic and temporal regions. Indeed, magnetic resonance imaging has revealed brain lesions in patients suffering from Capgras syndrome. This case study reports the findings of a thorough diagnostic evaluation in a woman suffering from Capgras syndrome and presenting with the following clinical peculiarities: obsessive modality of presentation of the delusional ideation, intrusiveness of such ideation (that even disturbed her sleep), as well as a sense of alienation and utter disgust towards the double. These characteristics bring to mind the typical aspects of obsessive-compulsive disorder. Neuroanatomic investigation, through magnetic resonance imaging, performed on this patient showed alteration of the bilateral semioval centers, which are brain regions associated with the emotion of disgust and often show alterations in subjects suffering from obsessive-compulsive disorder. Hence, neuroimaging allows researchers to put forward the hypothesis of a common neuroanatomic basis for Capgras syndrome and obsessive-compulsive disorder, at least for cases in which the delusional ideation is associated with deep feelings of disgust and presents with a certain pervasiveness.Keywords: Capgras syndrome, magnetic resonance imaging, electroencephalography, obsessive-compulsive disorder, semioval centersLuca MBordone ALuca APatti ASortino GCalandra CDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 1095-1099 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Luca M Bordone A Luca A Patti A Sortino G Calandra C Clinical features and imaging findings in a case of Capgras syndrome
description	Maria Luca,1 Andrea Bordone,1 Antonina Luca,2 Andrea Patti,1 Giuseppe Sortino,3 Carmela Calandra11Department of Medical and Surgery Specialties, Psychiatry Unit, 2Department GF Ingrassia, Section of Neuroscience, 3Department of Diagnostic Imaging, Radiology Unit, University Hospital Policlinico-Vittorio Emanuele, Catania, Sicily, ItalyAbstract: Capgras syndrome consists of the delusional belief that a person or persons have been replaced by doubles or impostors. It can occur in the context of both psychiatric and organic illness, and seems to be related to lesions of the bifrontal and right limbic and temporal regions. Indeed, magnetic resonance imaging has revealed brain lesions in patients suffering from Capgras syndrome. This case study reports the findings of a thorough diagnostic evaluation in a woman suffering from Capgras syndrome and presenting with the following clinical peculiarities: obsessive modality of presentation of the delusional ideation, intrusiveness of such ideation (that even disturbed her sleep), as well as a sense of alienation and utter disgust towards the double. These characteristics bring to mind the typical aspects of obsessive-compulsive disorder. Neuroanatomic investigation, through magnetic resonance imaging, performed on this patient showed alteration of the bilateral semioval centers, which are brain regions associated with the emotion of disgust and often show alterations in subjects suffering from obsessive-compulsive disorder. Hence, neuroimaging allows researchers to put forward the hypothesis of a common neuroanatomic basis for Capgras syndrome and obsessive-compulsive disorder, at least for cases in which the delusional ideation is associated with deep feelings of disgust and presents with a certain pervasiveness.Keywords: Capgras syndrome, magnetic resonance imaging, electroencephalography, obsessive-compulsive disorder, semioval centers
format	article
author	Luca M Bordone A Luca A Patti A Sortino G Calandra C
author_facet	Luca M Bordone A Luca A Patti A Sortino G Calandra C
author_sort	Luca M
title	Clinical features and imaging findings in a case of Capgras syndrome
title_short	Clinical features and imaging findings in a case of Capgras syndrome
title_full	Clinical features and imaging findings in a case of Capgras syndrome
title_fullStr	Clinical features and imaging findings in a case of Capgras syndrome
title_full_unstemmed	Clinical features and imaging findings in a case of Capgras syndrome
title_sort	clinical features and imaging findings in a case of capgras syndrome
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/bbb6b5e07f604aa0a7e24cce568cc9e6
work_keys_str_mv	AT lucam clinicalfeaturesandimagingfindingsinacaseofcapgrassyndrome AT bordonea clinicalfeaturesandimagingfindingsinacaseofcapgrassyndrome AT lucaa clinicalfeaturesandimagingfindingsinacaseofcapgrassyndrome AT pattia clinicalfeaturesandimagingfindingsinacaseofcapgrassyndrome AT sortinog clinicalfeaturesandimagingfindingsinacaseofcapgrassyndrome AT calandrac clinicalfeaturesandimagingfindingsinacaseofcapgrassyndrome
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Clinical features and imaging findings in a case of Capgras syndrome

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