PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA

Chromosomal rearrangements are key events in the pathogenesis of a range of disorders. Here the authors utilize a zinc finger nuclease translocation reporter to identify PARP3 as a regulator of these events at sites enriched for G quadruplex DNA.

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Autores principales:	Tovah A. Day, Jacob V. Layer, J. Patrick Cleary, Srijoy Guha, Kristen E. Stevenson, Trevor Tivey, Sunhee Kim, Anna C. Schinzel, Francesca Izzo, John Doench, David E. Root, William C. Hahn, Brendan D. Price, David M. Weinstock
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bbb73c46fe524682b8101ab1da9d52fc
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spelling	oai:doaj.org-article:bbb73c46fe524682b8101ab1da9d52fc2021-12-02T14:40:56ZPARP3 is a promoter of chromosomal rearrangements and limits G4 DNA10.1038/ncomms151102041-1723https://doaj.org/article/bbb73c46fe524682b8101ab1da9d52fc2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15110https://doaj.org/toc/2041-1723Chromosomal rearrangements are key events in the pathogenesis of a range of disorders. Here the authors utilize a zinc finger nuclease translocation reporter to identify PARP3 as a regulator of these events at sites enriched for G quadruplex DNA.Tovah A. DayJacob V. LayerJ. Patrick ClearySrijoy GuhaKristen E. StevensonTrevor TiveySunhee KimAnna C. SchinzelFrancesca IzzoJohn DoenchDavid E. RootWilliam C. HahnBrendan D. PriceDavid M. WeinstockNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tovah A. Day Jacob V. Layer J. Patrick Cleary Srijoy Guha Kristen E. Stevenson Trevor Tivey Sunhee Kim Anna C. Schinzel Francesca Izzo John Doench David E. Root William C. Hahn Brendan D. Price David M. Weinstock PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA
description	Chromosomal rearrangements are key events in the pathogenesis of a range of disorders. Here the authors utilize a zinc finger nuclease translocation reporter to identify PARP3 as a regulator of these events at sites enriched for G quadruplex DNA.
format	article
author	Tovah A. Day Jacob V. Layer J. Patrick Cleary Srijoy Guha Kristen E. Stevenson Trevor Tivey Sunhee Kim Anna C. Schinzel Francesca Izzo John Doench David E. Root William C. Hahn Brendan D. Price David M. Weinstock
author_facet	Tovah A. Day Jacob V. Layer J. Patrick Cleary Srijoy Guha Kristen E. Stevenson Trevor Tivey Sunhee Kim Anna C. Schinzel Francesca Izzo John Doench David E. Root William C. Hahn Brendan D. Price David M. Weinstock
author_sort	Tovah A. Day
title	PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA
title_short	PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA
title_full	PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA
title_fullStr	PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA
title_full_unstemmed	PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA
title_sort	parp3 is a promoter of chromosomal rearrangements and limits g4 dna
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bbb73c46fe524682b8101ab1da9d52fc
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PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA

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