Organotypic spinal cord cultures: An <em>in vitro</em> 3D model to preliminary screen treatments for spinal muscular atrophy

Spinal muscular atrophy (SMA) is a severe neuromuscular disease affecting children, due to mutation/deletion of survival motor neuron 1 (SMN1) gene. The lack of functional protein SMN determines motor neuron (MN) degeneration and skeletal muscle atrophy, leading to premature death due to respirator...

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Autores principales: Marina Boido, Elena De Amicis, Katia Mareschi, Franca Fagioli, Alessandro Vercelli
Formato: article
Lenguaje:EN
Publicado: PAGEPress Publications 2021
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Acceso en línea:https://doaj.org/article/bbba8f6e51404cb6b0df6e4954d4f06e
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