Spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain

Abstract Spreading depolarizations (SDs) occur spontaneously in the cerebral cortex of subarachnoid hemorrhage, stroke or traumatic brain injury patients. Accumulating evidence prove that SDs exacerbate focal ischemic injury by converting zones of the viable but non-functional ischemic penumbra to t...

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Autores principales: Ákos Menyhárt, Dániel Zölei-Szénási, Tamás Puskás, Péter Makra, M. Tóth Orsolya, Borbála É. Szepes, Réka Tóth, Orsolya Ivánkovits-Kiss, Tihomir P. Obrenovitch, Ferenc Bari, Eszter Farkas
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/bbc18ac3cbff40719225bcca66951cac
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spelling oai:doaj.org-article:bbc18ac3cbff40719225bcca66951cac2021-12-02T11:53:04ZSpreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain10.1038/s41598-017-01284-42045-2322https://doaj.org/article/bbc18ac3cbff40719225bcca66951cac2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01284-4https://doaj.org/toc/2045-2322Abstract Spreading depolarizations (SDs) occur spontaneously in the cerebral cortex of subarachnoid hemorrhage, stroke or traumatic brain injury patients. Accumulating evidence prove that SDs exacerbate focal ischemic injury by converting zones of the viable but non-functional ischemic penumbra to the core region beyond rescue. Yet the SD-related mechanisms to mediate neurodegeneration remain poorly understood. Here we show in the cerebral cortex of isoflurane-anesthetized, young and old laboratory rats, that SDs propagating under ischemic penumbra-like conditions decrease intra and- extracellular tissue pH transiently to levels, which have been recognized to cause tissue damage. Further, tissue pH after the passage of each spontaneous SD event remains acidic for over 10 minutes. Finally, the recovery from SD-related tissue acidosis is hampered further by age. We propose that accumulating acid load is an effective mechanism for SD to cause delayed cell death in the ischemic nervous tissue, particularly in the aged brain.Ákos MenyhártDániel Zölei-SzénásiTamás PuskásPéter MakraM. Tóth OrsolyaBorbála É. SzepesRéka TóthOrsolya Ivánkovits-KissTihomir P. ObrenovitchFerenc BariEszter FarkasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Ákos Menyhárt
Dániel Zölei-Szénási
Tamás Puskás
Péter Makra
M. Tóth Orsolya
Borbála É. Szepes
Réka Tóth
Orsolya Ivánkovits-Kiss
Tihomir P. Obrenovitch
Ferenc Bari
Eszter Farkas
Spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain
description Abstract Spreading depolarizations (SDs) occur spontaneously in the cerebral cortex of subarachnoid hemorrhage, stroke or traumatic brain injury patients. Accumulating evidence prove that SDs exacerbate focal ischemic injury by converting zones of the viable but non-functional ischemic penumbra to the core region beyond rescue. Yet the SD-related mechanisms to mediate neurodegeneration remain poorly understood. Here we show in the cerebral cortex of isoflurane-anesthetized, young and old laboratory rats, that SDs propagating under ischemic penumbra-like conditions decrease intra and- extracellular tissue pH transiently to levels, which have been recognized to cause tissue damage. Further, tissue pH after the passage of each spontaneous SD event remains acidic for over 10 minutes. Finally, the recovery from SD-related tissue acidosis is hampered further by age. We propose that accumulating acid load is an effective mechanism for SD to cause delayed cell death in the ischemic nervous tissue, particularly in the aged brain.
format article
author Ákos Menyhárt
Dániel Zölei-Szénási
Tamás Puskás
Péter Makra
M. Tóth Orsolya
Borbála É. Szepes
Réka Tóth
Orsolya Ivánkovits-Kiss
Tihomir P. Obrenovitch
Ferenc Bari
Eszter Farkas
author_facet Ákos Menyhárt
Dániel Zölei-Szénási
Tamás Puskás
Péter Makra
M. Tóth Orsolya
Borbála É. Szepes
Réka Tóth
Orsolya Ivánkovits-Kiss
Tihomir P. Obrenovitch
Ferenc Bari
Eszter Farkas
author_sort Ákos Menyhárt
title Spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain
title_short Spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain
title_full Spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain
title_fullStr Spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain
title_full_unstemmed Spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain
title_sort spreading depolarization remarkably exacerbates ischemia-induced tissue acidosis in the young and aged rat brain
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/bbc18ac3cbff40719225bcca66951cac
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