Assessing the efficacy of interventions to control indoor SARS-Cov-2 transmission: An agent-based modeling approach

Nonpharmaceutical interventions for minimizing indoor SARS-CoV-2 transmission continue to be critical tools for protecting susceptible individuals from infection, even as effective vaccines are produced and distributed globally. We developed a spatially-explicit agent-based model for simulating indo...

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Autores principales:	Trevor S. Farthing, Cristina Lanzas
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Aerosol Agent-based model COVID-19 Droplet Indoor transmission SARS-CoV-2 Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/bbc1e00bbcfc4be18915593c5594c64a
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spelling	oai:doaj.org-article:bbc1e00bbcfc4be18915593c5594c64a2021-11-18T04:46:18ZAssessing the efficacy of interventions to control indoor SARS-Cov-2 transmission: An agent-based modeling approach1755-436510.1016/j.epidem.2021.100524https://doaj.org/article/bbc1e00bbcfc4be18915593c5594c64a2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1755436521000694https://doaj.org/toc/1755-4365Nonpharmaceutical interventions for minimizing indoor SARS-CoV-2 transmission continue to be critical tools for protecting susceptible individuals from infection, even as effective vaccines are produced and distributed globally. We developed a spatially-explicit agent-based model for simulating indoor respiratory pathogen transmission during discrete events taking place in a single room within a sub-day time frame, and used it to compare effects of four interventions on reducing secondary SARS-CoV-2 attack rates during a superspreading event by simulating a well-known case study. We found that preventing people from moving within the simulated room and efficacious mask usage appear to have the greatest effects on reducing infection risk, but multiple concurrent interventions are required to minimize the proportion of susceptible individuals infected. Social distancing had little effect on reducing transmission if individuals were randomly relocated within the room to simulate activity-related movements during the gathering. Furthermore, our results suggest that there is potential for ventilation airflow to expose susceptible people to aerosolized pathogens even if they are relatively far from infectious individuals. Maximizing the vertical aerosol removal rate is paramount to successful transmission-risk reduction when using ventilation systems as intervention tools.Trevor S. FarthingCristina LanzasElsevierarticleAerosolAgent-based modelCOVID-19DropletIndoor transmissionSARS-CoV-2Infectious and parasitic diseasesRC109-216ENEpidemics, Vol 37, Iss , Pp 100524- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Aerosol Agent-based model COVID-19 Droplet Indoor transmission SARS-CoV-2 Infectious and parasitic diseases RC109-216
spellingShingle	Aerosol Agent-based model COVID-19 Droplet Indoor transmission SARS-CoV-2 Infectious and parasitic diseases RC109-216 Trevor S. Farthing Cristina Lanzas Assessing the efficacy of interventions to control indoor SARS-Cov-2 transmission: An agent-based modeling approach
description	Nonpharmaceutical interventions for minimizing indoor SARS-CoV-2 transmission continue to be critical tools for protecting susceptible individuals from infection, even as effective vaccines are produced and distributed globally. We developed a spatially-explicit agent-based model for simulating indoor respiratory pathogen transmission during discrete events taking place in a single room within a sub-day time frame, and used it to compare effects of four interventions on reducing secondary SARS-CoV-2 attack rates during a superspreading event by simulating a well-known case study. We found that preventing people from moving within the simulated room and efficacious mask usage appear to have the greatest effects on reducing infection risk, but multiple concurrent interventions are required to minimize the proportion of susceptible individuals infected. Social distancing had little effect on reducing transmission if individuals were randomly relocated within the room to simulate activity-related movements during the gathering. Furthermore, our results suggest that there is potential for ventilation airflow to expose susceptible people to aerosolized pathogens even if they are relatively far from infectious individuals. Maximizing the vertical aerosol removal rate is paramount to successful transmission-risk reduction when using ventilation systems as intervention tools.
format	article
author	Trevor S. Farthing Cristina Lanzas
author_facet	Trevor S. Farthing Cristina Lanzas
author_sort	Trevor S. Farthing
title	Assessing the efficacy of interventions to control indoor SARS-Cov-2 transmission: An agent-based modeling approach
title_short	Assessing the efficacy of interventions to control indoor SARS-Cov-2 transmission: An agent-based modeling approach
title_full	Assessing the efficacy of interventions to control indoor SARS-Cov-2 transmission: An agent-based modeling approach
title_fullStr	Assessing the efficacy of interventions to control indoor SARS-Cov-2 transmission: An agent-based modeling approach
title_full_unstemmed	Assessing the efficacy of interventions to control indoor SARS-Cov-2 transmission: An agent-based modeling approach
title_sort	assessing the efficacy of interventions to control indoor sars-cov-2 transmission: an agent-based modeling approach
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/bbc1e00bbcfc4be18915593c5594c64a
work_keys_str_mv	AT trevorsfarthing assessingtheefficacyofinterventionstocontrolindoorsarscov2transmissionanagentbasedmodelingapproach AT cristinalanzas assessingtheefficacyofinterventionstocontrolindoorsarscov2transmissionanagentbasedmodelingapproach
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Assessing the efficacy of interventions to control indoor SARS-Cov-2 transmission: An agent-based modeling approach

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