Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection

Salmonella Typhi produces the typhoid toxin, which damages host cell DNA. Here, Ibler et al. show that the toxin induces a non-canonical DNA damage response mediated by the RPA pathway that drives host cell senescence and facilitates infection.

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Autores principales:	Angela E. M. Ibler, Mohamed ElGhazaly, Kathryn L. Naylor, Natalia A. Bulgakova, Sherif F. El-Khamisy, Daniel Humphreys
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bbc570291cd04d3c81b454768cdc9aef
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spelling	oai:doaj.org-article:bbc570291cd04d3c81b454768cdc9aef2021-12-02T17:02:17ZTyphoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection10.1038/s41467-019-12064-12041-1723https://doaj.org/article/bbc570291cd04d3c81b454768cdc9aef2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12064-1https://doaj.org/toc/2041-1723Salmonella Typhi produces the typhoid toxin, which damages host cell DNA. Here, Ibler et al. show that the toxin induces a non-canonical DNA damage response mediated by the RPA pathway that drives host cell senescence and facilitates infection.Angela E. M. IblerMohamed ElGhazalyKathryn L. NaylorNatalia A. BulgakovaSherif F. El-KhamisyDaniel HumphreysNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Angela E. M. Ibler Mohamed ElGhazaly Kathryn L. Naylor Natalia A. Bulgakova Sherif F. El-Khamisy Daniel Humphreys Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection
description	Salmonella Typhi produces the typhoid toxin, which damages host cell DNA. Here, Ibler et al. show that the toxin induces a non-canonical DNA damage response mediated by the RPA pathway that drives host cell senescence and facilitates infection.
format	article
author	Angela E. M. Ibler Mohamed ElGhazaly Kathryn L. Naylor Natalia A. Bulgakova Sherif F. El-Khamisy Daniel Humphreys
author_facet	Angela E. M. Ibler Mohamed ElGhazaly Kathryn L. Naylor Natalia A. Bulgakova Sherif F. El-Khamisy Daniel Humphreys
author_sort	Angela E. M. Ibler
title	Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection
title_short	Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection
title_full	Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection
title_fullStr	Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection
title_full_unstemmed	Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection
title_sort	typhoid toxin exhausts the rpa response to dna replication stress driving senescence and salmonella infection
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bbc570291cd04d3c81b454768cdc9aef
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Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection

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