Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection
Salmonella Typhi produces the typhoid toxin, which damages host cell DNA. Here, Ibler et al. show that the toxin induces a non-canonical DNA damage response mediated by the RPA pathway that drives host cell senescence and facilitates infection.
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/bbc570291cd04d3c81b454768cdc9aef |
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