Mechanism of IRSp53 inhibition by 14-3-3

IRSp53 is a key regulator of filopodia formation and cell migration. Here, the authors elucidate a mechanism of phosphorylation-dependent inhibition of IRSp53 by 14-3-3, which impedes the interactions of IRSp53 with membranes and downstream cytoskeletal effectors.

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Autores principales:	David J. Kast, Roberto Dominguez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bbc58d89b3dc4cbe9c4e3713e91232cf
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spelling	oai:doaj.org-article:bbc58d89b3dc4cbe9c4e3713e91232cf2021-12-02T14:39:04ZMechanism of IRSp53 inhibition by 14-3-310.1038/s41467-019-08317-82041-1723https://doaj.org/article/bbc58d89b3dc4cbe9c4e3713e91232cf2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08317-8https://doaj.org/toc/2041-1723IRSp53 is a key regulator of filopodia formation and cell migration. Here, the authors elucidate a mechanism of phosphorylation-dependent inhibition of IRSp53 by 14-3-3, which impedes the interactions of IRSp53 with membranes and downstream cytoskeletal effectors.David J. KastRoberto DominguezNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David J. Kast Roberto Dominguez Mechanism of IRSp53 inhibition by 14-3-3
description	IRSp53 is a key regulator of filopodia formation and cell migration. Here, the authors elucidate a mechanism of phosphorylation-dependent inhibition of IRSp53 by 14-3-3, which impedes the interactions of IRSp53 with membranes and downstream cytoskeletal effectors.
format	article
author	David J. Kast Roberto Dominguez
author_facet	David J. Kast Roberto Dominguez
author_sort	David J. Kast
title	Mechanism of IRSp53 inhibition by 14-3-3
title_short	Mechanism of IRSp53 inhibition by 14-3-3
title_full	Mechanism of IRSp53 inhibition by 14-3-3
title_fullStr	Mechanism of IRSp53 inhibition by 14-3-3
title_full_unstemmed	Mechanism of IRSp53 inhibition by 14-3-3
title_sort	mechanism of irsp53 inhibition by 14-3-3
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bbc58d89b3dc4cbe9c4e3713e91232cf
work_keys_str_mv	AT davidjkast mechanismofirsp53inhibitionby1433 AT robertodominguez mechanismofirsp53inhibitionby1433
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Mechanism of IRSp53 inhibition by 14-3-3

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