Tissues and Cell Types of Appendage Regeneration: A Detailed Look at the Wound Epidermis and Its Specialized Forms

Therapeutic implementation of human limb regeneration is a daring aim. Studying species that can regrow their lost appendages provides clues on how such a feat can be achieved in mammals. One of the unique features of regeneration-competent species lies in their ability to seal the amputation plane...

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Autor principal:	Can Aztekin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	wound epidermis specialized wound epidermis AEC single-cell transcriptomics appendage regeneration limb regeneration Physiology QP1-981
Acceso en línea:	https://doaj.org/article/bbc61f9ea3ca42d89dd27f9abb071d11
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id	oai:doaj.org-article:bbc61f9ea3ca42d89dd27f9abb071d11
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spelling	oai:doaj.org-article:bbc61f9ea3ca42d89dd27f9abb071d112021-11-30T12:11:56ZTissues and Cell Types of Appendage Regeneration: A Detailed Look at the Wound Epidermis and Its Specialized Forms1664-042X10.3389/fphys.2021.771040https://doaj.org/article/bbc61f9ea3ca42d89dd27f9abb071d112021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.771040/fullhttps://doaj.org/toc/1664-042XTherapeutic implementation of human limb regeneration is a daring aim. Studying species that can regrow their lost appendages provides clues on how such a feat can be achieved in mammals. One of the unique features of regeneration-competent species lies in their ability to seal the amputation plane with a scar-free wound epithelium. Subsequently, this wound epithelium advances and becomes a specialized wound epidermis (WE) which is hypothesized to be the essential component of regenerative success. Recently, the WE and specialized WE terminologies have been used interchangeably. However, these tissues were historically separated, and contemporary limb regeneration studies have provided critical new information which allows us to distinguish them. Here, I will summarize tissue-level observations and recently identified cell types of WE and their specialized forms in different regeneration models.Can AztekinFrontiers Media S.A.articlewound epidermisspecialized wound epidermisAECsingle-cell transcriptomicsappendage regenerationlimb regenerationPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	wound epidermis specialized wound epidermis AEC single-cell transcriptomics appendage regeneration limb regeneration Physiology QP1-981
spellingShingle	wound epidermis specialized wound epidermis AEC single-cell transcriptomics appendage regeneration limb regeneration Physiology QP1-981 Can Aztekin Tissues and Cell Types of Appendage Regeneration: A Detailed Look at the Wound Epidermis and Its Specialized Forms
description	Therapeutic implementation of human limb regeneration is a daring aim. Studying species that can regrow their lost appendages provides clues on how such a feat can be achieved in mammals. One of the unique features of regeneration-competent species lies in their ability to seal the amputation plane with a scar-free wound epithelium. Subsequently, this wound epithelium advances and becomes a specialized wound epidermis (WE) which is hypothesized to be the essential component of regenerative success. Recently, the WE and specialized WE terminologies have been used interchangeably. However, these tissues were historically separated, and contemporary limb regeneration studies have provided critical new information which allows us to distinguish them. Here, I will summarize tissue-level observations and recently identified cell types of WE and their specialized forms in different regeneration models.
format	article
author	Can Aztekin
author_facet	Can Aztekin
author_sort	Can Aztekin
title	Tissues and Cell Types of Appendage Regeneration: A Detailed Look at the Wound Epidermis and Its Specialized Forms
title_short	Tissues and Cell Types of Appendage Regeneration: A Detailed Look at the Wound Epidermis and Its Specialized Forms
title_full	Tissues and Cell Types of Appendage Regeneration: A Detailed Look at the Wound Epidermis and Its Specialized Forms
title_fullStr	Tissues and Cell Types of Appendage Regeneration: A Detailed Look at the Wound Epidermis and Its Specialized Forms
title_full_unstemmed	Tissues and Cell Types of Appendage Regeneration: A Detailed Look at the Wound Epidermis and Its Specialized Forms
title_sort	tissues and cell types of appendage regeneration: a detailed look at the wound epidermis and its specialized forms
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/bbc61f9ea3ca42d89dd27f9abb071d11
work_keys_str_mv	AT canaztekin tissuesandcelltypesofappendageregenerationadetailedlookatthewoundepidermisanditsspecializedforms
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Tissues and Cell Types of Appendage Regeneration: A Detailed Look at the Wound Epidermis and Its Specialized Forms

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