$Response of serous retinal pigment epithelial detachments to intravitreal aflibercept in polypoidal choroidal vasculopathy refractory to ranibizumab$
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Response of serous retinal pigment epithelial detachments to intravitreal aflibercept in polypoidal choroidal vasculopathy refractory to ranibizumab

Mariko Yamashita, Tomo Nishi, Taiji Hasegawa, Nahoko Ogata Department of Ophthalmology, Nara Medical University, Kashihara, Nara, Japan Purpose: To report the effects of aflibercept on eyes with large retinal pigment epithelial detachment (PED) associted with polypoidal choroidal vasculopathy (PCV...

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Autores principales:	Yamashita M, Nishi T, Hasegawa T, Ogata N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/bbc6f9b673914f74a660c42fc79e7245
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spelling	oai:doaj.org-article:bbc6f9b673914f74a660c42fc79e72452021-12-02T07:19:08ZResponse of serous retinal pigment epithelial detachments to intravitreal aflibercept in polypoidal choroidal vasculopathy refractory to ranibizumab1177-5483https://doaj.org/article/bbc6f9b673914f74a660c42fc79e72452014-02-01T00:00:00Zhttp://www.dovepress.com/response-of-serous-retinal-pigment-epithelial-detachments-to-intravitr-a15703https://doaj.org/toc/1177-5483 Mariko Yamashita, Tomo Nishi, Taiji Hasegawa, Nahoko Ogata Department of Ophthalmology, Nara Medical University, Kashihara, Nara, Japan Purpose: To report the effects of aflibercept on eyes with large retinal pigment epithelial detachment (PED) associted with polypoidal choroidal vasculopathy (PCV). Methods: We reviewed the medical records of patients with PEDs associated with PCV that were treated with aflibercept after intravitreal ranibizumab had failed. Results: Three eyes of patients aged 72, 79, and 80 years were studied. Reflective material was seen in the PED along the outer surface of the retinal pigment epithelium (RPE) by spectral-domain optical coherence tomography (SD-OCT). A complete resolution of the serous PEDs was found after two aflibercept injections; however, all eyes had a fibrovascular PED. In addition, one eye developed a retinal hemorrhage and a recurrent PED just after the third injection of aflibercept. The visual acuity in this eye decreased from 10/20 to 2/20. Conclusion: The reflective material below the outer surface of the RPE in serous PED suggests the presence of neovascularization. Intravitreal aflibercept could be considered for large PEDs in eyes with PCV but should be carefully applied. Keywords: age-related macular degeneration, retinal pigment epithelial detachment, polypoidal choroidal vasculopathy, afliberceptYamashita MNishi THasegawa TOgata NDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 343-346 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Yamashita M Nishi T Hasegawa T Ogata N Response of serous retinal pigment epithelial detachments to intravitreal aflibercept in polypoidal choroidal vasculopathy refractory to ranibizumab
description	Mariko Yamashita, Tomo Nishi, Taiji Hasegawa, Nahoko Ogata Department of Ophthalmology, Nara Medical University, Kashihara, Nara, Japan Purpose: To report the effects of aflibercept on eyes with large retinal pigment epithelial detachment (PED) associted with polypoidal choroidal vasculopathy (PCV). Methods: We reviewed the medical records of patients with PEDs associated with PCV that were treated with aflibercept after intravitreal ranibizumab had failed. Results: Three eyes of patients aged 72, 79, and 80 years were studied. Reflective material was seen in the PED along the outer surface of the retinal pigment epithelium (RPE) by spectral-domain optical coherence tomography (SD-OCT). A complete resolution of the serous PEDs was found after two aflibercept injections; however, all eyes had a fibrovascular PED. In addition, one eye developed a retinal hemorrhage and a recurrent PED just after the third injection of aflibercept. The visual acuity in this eye decreased from 10/20 to 2/20. Conclusion: The reflective material below the outer surface of the RPE in serous PED suggests the presence of neovascularization. Intravitreal aflibercept could be considered for large PEDs in eyes with PCV but should be carefully applied. Keywords: age-related macular degeneration, retinal pigment epithelial detachment, polypoidal choroidal vasculopathy, aflibercept
format	article
author	Yamashita M Nishi T Hasegawa T Ogata N
author_facet	Yamashita M Nishi T Hasegawa T Ogata N
author_sort	Yamashita M
title	Response of serous retinal pigment epithelial detachments to intravitreal aflibercept in polypoidal choroidal vasculopathy refractory to ranibizumab
title_short	Response of serous retinal pigment epithelial detachments to intravitreal aflibercept in polypoidal choroidal vasculopathy refractory to ranibizumab
title_full	Response of serous retinal pigment epithelial detachments to intravitreal aflibercept in polypoidal choroidal vasculopathy refractory to ranibizumab
title_fullStr	Response of serous retinal pigment epithelial detachments to intravitreal aflibercept in polypoidal choroidal vasculopathy refractory to ranibizumab
title_full_unstemmed	Response of serous retinal pigment epithelial detachments to intravitreal aflibercept in polypoidal choroidal vasculopathy refractory to ranibizumab
title_sort	response of serous retinal pigment epithelial detachments to intravitreal aflibercept in polypoidal choroidal vasculopathy refractory to ranibizumab
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/bbc6f9b673914f74a660c42fc79e7245
work_keys_str_mv	AT yamashitam responseofserousretinalpigmentepithelialdetachmentstointravitrealafliberceptinpolypoidalchoroidalvasculopathyrefractorytoranibizumab AT nishit responseofserousretinalpigmentepithelialdetachmentstointravitrealafliberceptinpolypoidalchoroidalvasculopathyrefractorytoranibizumab AT hasegawat responseofserousretinalpigmentepithelialdetachmentstointravitrealafliberceptinpolypoidalchoroidalvasculopathyrefractorytoranibizumab AT ogatan responseofserousretinalpigmentepithelialdetachmentstointravitrealafliberceptinpolypoidalchoroidalvasculopathyrefractorytoranibizumab
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Response of serous retinal pigment epithelial detachments to intravitreal aflibercept in polypoidal choroidal vasculopathy refractory to ranibizumab

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