Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF1

U2AF1 binds to the 3’ splice site of introns and its mutation lead to abnormal splicing. Here the authors solve the crystal structures of wild type and pathogenic mutant U2AF1 bound to target RNA, showing that different target sequence is preferred by pathogenic mutant.

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Autores principales:	Hisashi Yoshida, Sam-Yong Park, Gyosuke Sakashita, Yuko Nariai, Kanako Kuwasako, Yutaka Muto, Takeshi Urano, Eiji Obayashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bbcab2b8d7fe42eca46d1130a52a6b8e
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spelling	oai:doaj.org-article:bbcab2b8d7fe42eca46d1130a52a6b8e2021-12-02T17:26:57ZElucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF110.1038/s41467-020-18559-62041-1723https://doaj.org/article/bbcab2b8d7fe42eca46d1130a52a6b8e2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18559-6https://doaj.org/toc/2041-1723U2AF1 binds to the 3’ splice site of introns and its mutation lead to abnormal splicing. Here the authors solve the crystal structures of wild type and pathogenic mutant U2AF1 bound to target RNA, showing that different target sequence is preferred by pathogenic mutant.Hisashi YoshidaSam-Yong ParkGyosuke SakashitaYuko NariaiKanako KuwasakoYutaka MutoTakeshi UranoEiji ObayashiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hisashi Yoshida Sam-Yong Park Gyosuke Sakashita Yuko Nariai Kanako Kuwasako Yutaka Muto Takeshi Urano Eiji Obayashi Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF1
description	U2AF1 binds to the 3’ splice site of introns and its mutation lead to abnormal splicing. Here the authors solve the crystal structures of wild type and pathogenic mutant U2AF1 bound to target RNA, showing that different target sequence is preferred by pathogenic mutant.
format	article
author	Hisashi Yoshida Sam-Yong Park Gyosuke Sakashita Yuko Nariai Kanako Kuwasako Yutaka Muto Takeshi Urano Eiji Obayashi
author_facet	Hisashi Yoshida Sam-Yong Park Gyosuke Sakashita Yuko Nariai Kanako Kuwasako Yutaka Muto Takeshi Urano Eiji Obayashi
author_sort	Hisashi Yoshida
title	Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF1
title_short	Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF1
title_full	Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF1
title_fullStr	Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF1
title_full_unstemmed	Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF1
title_sort	elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the u2af1
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bbcab2b8d7fe42eca46d1130a52a6b8e
work_keys_str_mv	AT hisashiyoshida elucidationoftheaberrant3splicesiteselectionbycancerassociatedmutationsontheu2af1 AT samyongpark elucidationoftheaberrant3splicesiteselectionbycancerassociatedmutationsontheu2af1 AT gyosukesakashita elucidationoftheaberrant3splicesiteselectionbycancerassociatedmutationsontheu2af1 AT yukonariai elucidationoftheaberrant3splicesiteselectionbycancerassociatedmutationsontheu2af1 AT kanakokuwasako elucidationoftheaberrant3splicesiteselectionbycancerassociatedmutationsontheu2af1 AT yutakamuto elucidationoftheaberrant3splicesiteselectionbycancerassociatedmutationsontheu2af1 AT takeshiurano elucidationoftheaberrant3splicesiteselectionbycancerassociatedmutationsontheu2af1 AT eijiobayashi elucidationoftheaberrant3splicesiteselectionbycancerassociatedmutationsontheu2af1
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Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF1

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