Digit ratio (2Dratio4D) differences between 20 strains of inbred mice.

The second to fourth digit ratio (2Dratio4D) is sexually differentiated in a variety of species, including humans, rats, birds, and lizards. In humans, this ratio tends to be lower in males than in females. Lower digit ratios are believed to indicate increased prenatal testosterone exposure, and are...

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Autores principales:	Reginia H Y Yan, Mark Bunning, Douglas Wahlsten, Peter L Hurd
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bbcbce4f5d5844a0bc25c2c1240f3415
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spelling	oai:doaj.org-article:bbcbce4f5d5844a0bc25c2c1240f34152021-11-25T06:22:18ZDigit ratio (2Dratio4D) differences between 20 strains of inbred mice.1932-620310.1371/journal.pone.0005801https://doaj.org/article/bbcbce4f5d5844a0bc25c2c1240f34152009-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19495421/?tool=EBIhttps://doaj.org/toc/1932-6203The second to fourth digit ratio (2Dratio4D) is sexually differentiated in a variety of species, including humans, rats, birds, and lizards. In humans, this ratio tends to be lower in males than in females. Lower digit ratios are believed to indicate increased prenatal testosterone exposure, and are associated with more masculinized behavior across a range of traits. The story seems more complicated in laboratory mice. We have previously shown that there is no sex difference in the digit ratios of inbred mice, but found behavioral evidence to suggest that higher 2Dratio4D is associated with more masculinized behaviors. Work examining intrauterine position effects show that neighbouring males raise pup digit ratio, suggesting again that higher digit ratios are associated with increased developmental androgens. Other work has suggested that masculinization is associated with lower digit ratios in lab mice. Here, we examine the fore- and hindlimb digit ratios of 20 inbred mouse strains. We find large inter-strain differences, but no sexual dimorphism. Digit ratios also did not correlate with mice behavioral traits. This result calls into question the use of this trait as a broadly applicable indicator for prenatal androgen exposure. We suggest that the inbred mice model presents an opportunity for researchers to investigate the genetic, and gene-environmental influence on the development of digit ratios.Reginia H Y YanMark BunningDouglas WahlstenPeter L HurdPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 6, p e5801 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Reginia H Y Yan Mark Bunning Douglas Wahlsten Peter L Hurd Digit ratio (2Dratio4D) differences between 20 strains of inbred mice.
description	The second to fourth digit ratio (2Dratio4D) is sexually differentiated in a variety of species, including humans, rats, birds, and lizards. In humans, this ratio tends to be lower in males than in females. Lower digit ratios are believed to indicate increased prenatal testosterone exposure, and are associated with more masculinized behavior across a range of traits. The story seems more complicated in laboratory mice. We have previously shown that there is no sex difference in the digit ratios of inbred mice, but found behavioral evidence to suggest that higher 2Dratio4D is associated with more masculinized behaviors. Work examining intrauterine position effects show that neighbouring males raise pup digit ratio, suggesting again that higher digit ratios are associated with increased developmental androgens. Other work has suggested that masculinization is associated with lower digit ratios in lab mice. Here, we examine the fore- and hindlimb digit ratios of 20 inbred mouse strains. We find large inter-strain differences, but no sexual dimorphism. Digit ratios also did not correlate with mice behavioral traits. This result calls into question the use of this trait as a broadly applicable indicator for prenatal androgen exposure. We suggest that the inbred mice model presents an opportunity for researchers to investigate the genetic, and gene-environmental influence on the development of digit ratios.
format	article
author	Reginia H Y Yan Mark Bunning Douglas Wahlsten Peter L Hurd
author_facet	Reginia H Y Yan Mark Bunning Douglas Wahlsten Peter L Hurd
author_sort	Reginia H Y Yan
title	Digit ratio (2Dratio4D) differences between 20 strains of inbred mice.
title_short	Digit ratio (2Dratio4D) differences between 20 strains of inbred mice.
title_full	Digit ratio (2Dratio4D) differences between 20 strains of inbred mice.
title_fullStr	Digit ratio (2Dratio4D) differences between 20 strains of inbred mice.
title_full_unstemmed	Digit ratio (2Dratio4D) differences between 20 strains of inbred mice.
title_sort	digit ratio (2dratio4d) differences between 20 strains of inbred mice.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/bbcbce4f5d5844a0bc25c2c1240f3415
work_keys_str_mv	AT reginiahyyan digitratio2dratio4ddifferencesbetween20strainsofinbredmice AT markbunning digitratio2dratio4ddifferencesbetween20strainsofinbredmice AT douglaswahlsten digitratio2dratio4ddifferencesbetween20strainsofinbredmice AT peterlhurd digitratio2dratio4ddifferencesbetween20strainsofinbredmice
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Digit ratio (2Dratio4D) differences between 20 strains of inbred mice.

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