Macrophagic myofasciitis: an atypical presentation for a rare disease with a challenging approach

Macrophagic myofasciitis (MMF) is a rare immune-mediated myopathy that seems to be triggered by aluminium hydroxide adjuvant used in vaccines. Its presentation is relatively heterogeneous and treatment with steroids leads to improvement, although there is little evidence regarding the role of other...

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Autores principales:	Rita Dias, Raquel Faria, Diogo Ribeiro, Carlos Vasconcelos
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2020
Materias:	macrophagic myofasciitis vaccines aluminium hydroxide adjuvant tacrolimus mycophenolate mofetil asia. Medicine R
Acceso en línea:	https://doaj.org/article/bbcc005cf98543a9bcd0656455ed04ba
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spelling	oai:doaj.org-article:bbcc005cf98543a9bcd0656455ed04ba2021-12-02T18:54:24ZMacrophagic myofasciitis: an atypical presentation for a rare disease with a challenging approach0034-62332084-983410.5114/reum.2020.96683https://doaj.org/article/bbcc005cf98543a9bcd0656455ed04ba2020-06-01T00:00:00Zhttps://www.termedia.pl/Macrophagic-myofasciitis-an-atypical-presentation-for-a-rare-disease-with-a-challenging-approach,18,41081,1,1.htmlhttps://doaj.org/toc/0034-6233https://doaj.org/toc/2084-9834Macrophagic myofasciitis (MMF) is a rare immune-mediated myopathy that seems to be triggered by aluminium hydroxide adjuvant used in vaccines. Its presentation is relatively heterogeneous and treatment with steroids leads to improvement, although there is little evidence regarding the role of other immunosuppressants. The histological findings in MMF seem to be the result of an abnormal presence in the inoculation site of aluminium, which can induce an immune-mediated muscular disease in susceptible persons. The authors describe the case of a patient with an atypical presentation of macrophagic myofasciitis, with histological confirmation in a muscle biopsy distant from the inoculation site, and a good therapeutic response to tacrolimus and mycophenolate mofetil, as well as a discussion on the pathologic basis, controversies and emerging treatments for this condition.Rita DiasRaquel FariaDiogo RibeiroCarlos VasconcelosTermedia Publishing Housearticlemacrophagic myofasciitis vaccines aluminium hydroxide adjuvant tacrolimus mycophenolate mofetil asia.MedicineRENRheumatology, Vol 58, Iss 3, Pp 167-172 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	macrophagic myofasciitis vaccines aluminium hydroxide adjuvant tacrolimus mycophenolate mofetil asia. Medicine R
spellingShingle	macrophagic myofasciitis vaccines aluminium hydroxide adjuvant tacrolimus mycophenolate mofetil asia. Medicine R Rita Dias Raquel Faria Diogo Ribeiro Carlos Vasconcelos Macrophagic myofasciitis: an atypical presentation for a rare disease with a challenging approach
description	Macrophagic myofasciitis (MMF) is a rare immune-mediated myopathy that seems to be triggered by aluminium hydroxide adjuvant used in vaccines. Its presentation is relatively heterogeneous and treatment with steroids leads to improvement, although there is little evidence regarding the role of other immunosuppressants. The histological findings in MMF seem to be the result of an abnormal presence in the inoculation site of aluminium, which can induce an immune-mediated muscular disease in susceptible persons. The authors describe the case of a patient with an atypical presentation of macrophagic myofasciitis, with histological confirmation in a muscle biopsy distant from the inoculation site, and a good therapeutic response to tacrolimus and mycophenolate mofetil, as well as a discussion on the pathologic basis, controversies and emerging treatments for this condition.
format	article
author	Rita Dias Raquel Faria Diogo Ribeiro Carlos Vasconcelos
author_facet	Rita Dias Raquel Faria Diogo Ribeiro Carlos Vasconcelos
author_sort	Rita Dias
title	Macrophagic myofasciitis: an atypical presentation for a rare disease with a challenging approach
title_short	Macrophagic myofasciitis: an atypical presentation for a rare disease with a challenging approach
title_full	Macrophagic myofasciitis: an atypical presentation for a rare disease with a challenging approach
title_fullStr	Macrophagic myofasciitis: an atypical presentation for a rare disease with a challenging approach
title_full_unstemmed	Macrophagic myofasciitis: an atypical presentation for a rare disease with a challenging approach
title_sort	macrophagic myofasciitis: an atypical presentation for a rare disease with a challenging approach
publisher	Termedia Publishing House
publishDate	2020
url	https://doaj.org/article/bbcc005cf98543a9bcd0656455ed04ba
work_keys_str_mv	AT ritadias macrophagicmyofasciitisanatypicalpresentationforararediseasewithachallengingapproach AT raquelfaria macrophagicmyofasciitisanatypicalpresentationforararediseasewithachallengingapproach AT diogoribeiro macrophagicmyofasciitisanatypicalpresentationforararediseasewithachallengingapproach AT carlosvasconcelos macrophagicmyofasciitisanatypicalpresentationforararediseasewithachallengingapproach
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Macrophagic myofasciitis: an atypical presentation for a rare disease with a challenging approach

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