Development of ocular hypertension and persistent glaucoma after intravitreal injection of triamcinolone

M Selim Kocabora, Cemil Yilmazli, Muhittin Taskapili, Gokhan Gulkilik, Sahan DurmazVakif Gureba Education and Research Hospital, Istanbul, TurkeyPurpose: This study evaluates intraocular pressure (IOP) elevation secondary to intravitreal injection of triamcinolone acetonide (IVTA) and discusses its...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	M Selim Kocabora, Cemil Yilmazli, Muhittin Taskapili, Gokhan Gulkilik, Sahan Durmaz
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/bbcd395f1a2b4ca68fdc0beec6bf6d0b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bbcd395f1a2b4ca68fdc0beec6bf6d0b
record_format	dspace
spelling	oai:doaj.org-article:bbcd395f1a2b4ca68fdc0beec6bf6d0b2021-12-02T06:09:50ZDevelopment of ocular hypertension and persistent glaucoma after intravitreal injection of triamcinolone1177-54671177-5483https://doaj.org/article/bbcd395f1a2b4ca68fdc0beec6bf6d0b2008-03-01T00:00:00Zhttp://www.dovepress.com/development-of-ocular-hypertension-and-persistent-glaucoma-after-intra-a363https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483M Selim Kocabora, Cemil Yilmazli, Muhittin Taskapili, Gokhan Gulkilik, Sahan DurmazVakif Gureba Education and Research Hospital, Istanbul, TurkeyPurpose: This study evaluates intraocular pressure (IOP) elevation secondary to intravitreal injection of triamcinolone acetonide (IVTA) and discusses its management.Methods: The records of 175 patients who underwent IVTA treatment and regular eye examinations in the period 2003&ndash;2006 were reviewed. One hundred and twenty-two of these patients were included in the study, of which 147 eyes that received IVTA (4 mg/0.1 ml) were followed for at least 9 months. Mean IOPs observed after IVTA injection as well as IOP elevations defined as moderate (&ge;5 mm Hg), important (&ge;10 mm Hg) and severe (&gt;25 mm Hg) during the follow-up period were evaluated and compared statistically.Results: Overall, the mean IOPs following IVTA injection were statistically significantly higher than the preinjection IOP (15.8 &plusmn; 2.6), after the first hour (17.7 &plusmn; 2.9), the first week (18.7 &plusmn; 4.1), the first month (19.6 &plusmn; 6.2), the second month (19.1 &plusmn; 6.1), the third month (18.0 &plusmn; 4.1), the sixth month (17.3 &plusmn; 4.0), and the ninth month (17.0 &plusmn; 2.7), but not after the first day (16.3 &plusmn; 7.6). Important IOP elevations were observed mostly in the first (17.7%) and second months (10.2%). In 40 (27.7%) eyes, topical antiglaucomatous therapy was needed and 7 later required surgical intervention to lower the IOP. Of the remaining 33 eyes, topical treatment was continued in 14 (9.5%) because of IOPs &ge;20 mm Hg.Conclusion: The persistence of IOP elevation beyond the IVTA clearance period and the development of intractable secondary glaucoma requiring surgical intervention substantiate the need for careful consideration of IVTA indication and follow-up.Keywords: intravitreal triamcinolone, intraocular pressure, steroid-induced glaucoma M Selim KocaboraCemil YilmazliMuhittin TaskapiliGokhan GulkilikSahan DurmazDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 1, Pp 167-171 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 M Selim Kocabora Cemil Yilmazli Muhittin Taskapili Gokhan Gulkilik Sahan Durmaz Development of ocular hypertension and persistent glaucoma after intravitreal injection of triamcinolone
description	M Selim Kocabora, Cemil Yilmazli, Muhittin Taskapili, Gokhan Gulkilik, Sahan DurmazVakif Gureba Education and Research Hospital, Istanbul, TurkeyPurpose: This study evaluates intraocular pressure (IOP) elevation secondary to intravitreal injection of triamcinolone acetonide (IVTA) and discusses its management.Methods: The records of 175 patients who underwent IVTA treatment and regular eye examinations in the period 2003&ndash;2006 were reviewed. One hundred and twenty-two of these patients were included in the study, of which 147 eyes that received IVTA (4 mg/0.1 ml) were followed for at least 9 months. Mean IOPs observed after IVTA injection as well as IOP elevations defined as moderate (&ge;5 mm Hg), important (&ge;10 mm Hg) and severe (&gt;25 mm Hg) during the follow-up period were evaluated and compared statistically.Results: Overall, the mean IOPs following IVTA injection were statistically significantly higher than the preinjection IOP (15.8 &plusmn; 2.6), after the first hour (17.7 &plusmn; 2.9), the first week (18.7 &plusmn; 4.1), the first month (19.6 &plusmn; 6.2), the second month (19.1 &plusmn; 6.1), the third month (18.0 &plusmn; 4.1), the sixth month (17.3 &plusmn; 4.0), and the ninth month (17.0 &plusmn; 2.7), but not after the first day (16.3 &plusmn; 7.6). Important IOP elevations were observed mostly in the first (17.7%) and second months (10.2%). In 40 (27.7%) eyes, topical antiglaucomatous therapy was needed and 7 later required surgical intervention to lower the IOP. Of the remaining 33 eyes, topical treatment was continued in 14 (9.5%) because of IOPs &ge;20 mm Hg.Conclusion: The persistence of IOP elevation beyond the IVTA clearance period and the development of intractable secondary glaucoma requiring surgical intervention substantiate the need for careful consideration of IVTA indication and follow-up.Keywords: intravitreal triamcinolone, intraocular pressure, steroid-induced glaucoma
format	article
author	M Selim Kocabora Cemil Yilmazli Muhittin Taskapili Gokhan Gulkilik Sahan Durmaz
author_facet	M Selim Kocabora Cemil Yilmazli Muhittin Taskapili Gokhan Gulkilik Sahan Durmaz
author_sort	M Selim Kocabora
title	Development of ocular hypertension and persistent glaucoma after intravitreal injection of triamcinolone
title_short	Development of ocular hypertension and persistent glaucoma after intravitreal injection of triamcinolone
title_full	Development of ocular hypertension and persistent glaucoma after intravitreal injection of triamcinolone
title_fullStr	Development of ocular hypertension and persistent glaucoma after intravitreal injection of triamcinolone
title_full_unstemmed	Development of ocular hypertension and persistent glaucoma after intravitreal injection of triamcinolone
title_sort	development of ocular hypertension and persistent glaucoma after intravitreal injection of triamcinolone
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/bbcd395f1a2b4ca68fdc0beec6bf6d0b
work_keys_str_mv	AT mselimkocabora developmentofocularhypertensionandpersistentglaucomaafterintravitrealinjectionoftriamcinolone AT cemilyilmazli developmentofocularhypertensionandpersistentglaucomaafterintravitrealinjectionoftriamcinolone AT muhittintaskapili developmentofocularhypertensionandpersistentglaucomaafterintravitrealinjectionoftriamcinolone AT gokhangulkilik developmentofocularhypertensionandpersistentglaucomaafterintravitrealinjectionoftriamcinolone AT sahandurmaz developmentofocularhypertensionandpersistentglaucomaafterintravitrealinjectionoftriamcinolone
_version_	1718400073449078784

Development of ocular hypertension and persistent glaucoma after intravitreal injection of triamcinolone

Ejemplares similares