Two dominant patterns of low anterior resection syndrome and their effects on patients’ quality of life

Abstract To identify low anterior resection syndrome (LARS) patterns and their associations with risk factors and quality of life (QOL). This cross-sectional study analyzed patients who underwent restorative anterior resection for left-sided colorectal cancer at Seoul National University Hospital, S...

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Autores principales:	Min Jung Kim, Ji Won Park, Mi Ae Lee, Han-Ki Lim, Yoon-Hye Kwon, Seung-Bum Ryoo, Kyu Joo Park, Seung-Yong Jeong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bbce871bca754cd0b1317eecc7f5bdf3
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spelling	oai:doaj.org-article:bbce871bca754cd0b1317eecc7f5bdf32021-12-02T14:11:30ZTwo dominant patterns of low anterior resection syndrome and their effects on patients’ quality of life10.1038/s41598-021-82149-92045-2322https://doaj.org/article/bbce871bca754cd0b1317eecc7f5bdf32021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82149-9https://doaj.org/toc/2045-2322Abstract To identify low anterior resection syndrome (LARS) patterns and their associations with risk factors and quality of life (QOL). This cross-sectional study analyzed patients who underwent restorative anterior resection for left-sided colorectal cancer at Seoul National University Hospital, Seoul, Republic of Korea. We administered LARS questionnaires to assess bowel dysfunction and quality of life between April 2017 and November 2019. LARS patterns were classified based on factor analyses. Variable effects on LARS patterns were estimated using logistic regression analysis. The risk factors and quality of life associated with dominant LARS patterns were analyzed. Data of 283 patients with a median follow-up duration of 24 months were analyzed. Major LARS was observed in 123 (43.3%) patients. Radiotherapy (odds ratio [OR]: 2.851, 95% confidence interval [95% CI]: 2.504–43.958, p = 0.002), low anastomosis (OR: 10.492, 95% CI: 2.504–43.958, p = 0.001), and complications (OR: 2.163, 95% CI: 1.100–4.255, p = 0.025) were independently associated with major LARS. LARS was classified into incontinence- or frequency-dominant types. Risk factors for incontinence-dominant LARS were radiotherapy and complications, whereas those for frequency-dominant LARS included low tumor location. Patients with incontinence-dominant patterns showed lower emotional function, whereas those with frequency-dominant patterns showed lower global health QOL, lower emotional, cognitive, and social functions, and higher incidence of pain and diarrhea. Frequency-dominant LARS had a greater negative effect on QOL than incontinence-dominant LARS. These patterns could be used for preoperative prediction and postoperative treatment of LARS.Min Jung KimJi Won ParkMi Ae LeeHan-Ki LimYoon-Hye KwonSeung-Bum RyooKyu Joo ParkSeung-Yong JeongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Min Jung Kim Ji Won Park Mi Ae Lee Han-Ki Lim Yoon-Hye Kwon Seung-Bum Ryoo Kyu Joo Park Seung-Yong Jeong Two dominant patterns of low anterior resection syndrome and their effects on patients’ quality of life
description	Abstract To identify low anterior resection syndrome (LARS) patterns and their associations with risk factors and quality of life (QOL). This cross-sectional study analyzed patients who underwent restorative anterior resection for left-sided colorectal cancer at Seoul National University Hospital, Seoul, Republic of Korea. We administered LARS questionnaires to assess bowel dysfunction and quality of life between April 2017 and November 2019. LARS patterns were classified based on factor analyses. Variable effects on LARS patterns were estimated using logistic regression analysis. The risk factors and quality of life associated with dominant LARS patterns were analyzed. Data of 283 patients with a median follow-up duration of 24 months were analyzed. Major LARS was observed in 123 (43.3%) patients. Radiotherapy (odds ratio [OR]: 2.851, 95% confidence interval [95% CI]: 2.504–43.958, p = 0.002), low anastomosis (OR: 10.492, 95% CI: 2.504–43.958, p = 0.001), and complications (OR: 2.163, 95% CI: 1.100–4.255, p = 0.025) were independently associated with major LARS. LARS was classified into incontinence- or frequency-dominant types. Risk factors for incontinence-dominant LARS were radiotherapy and complications, whereas those for frequency-dominant LARS included low tumor location. Patients with incontinence-dominant patterns showed lower emotional function, whereas those with frequency-dominant patterns showed lower global health QOL, lower emotional, cognitive, and social functions, and higher incidence of pain and diarrhea. Frequency-dominant LARS had a greater negative effect on QOL than incontinence-dominant LARS. These patterns could be used for preoperative prediction and postoperative treatment of LARS.
format	article
author	Min Jung Kim Ji Won Park Mi Ae Lee Han-Ki Lim Yoon-Hye Kwon Seung-Bum Ryoo Kyu Joo Park Seung-Yong Jeong
author_facet	Min Jung Kim Ji Won Park Mi Ae Lee Han-Ki Lim Yoon-Hye Kwon Seung-Bum Ryoo Kyu Joo Park Seung-Yong Jeong
author_sort	Min Jung Kim
title	Two dominant patterns of low anterior resection syndrome and their effects on patients’ quality of life
title_short	Two dominant patterns of low anterior resection syndrome and their effects on patients’ quality of life
title_full	Two dominant patterns of low anterior resection syndrome and their effects on patients’ quality of life
title_fullStr	Two dominant patterns of low anterior resection syndrome and their effects on patients’ quality of life
title_full_unstemmed	Two dominant patterns of low anterior resection syndrome and their effects on patients’ quality of life
title_sort	two dominant patterns of low anterior resection syndrome and their effects on patients’ quality of life
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bbce871bca754cd0b1317eecc7f5bdf3
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Two dominant patterns of low anterior resection syndrome and their effects on patients’ quality of life

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