Steric interactions lead to collective tilting motion in the ribosome during mRNA–tRNA translocation

During protein elongation, the translocation of mRNA and tRNA molecules across the 30S ribosomal subunit is associated with large-scale motions of the 30S head domain. Here the authors carry out MD simulations to probe the associated steric interactions and identify novel tilting motions during the...

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Detalles Bibliográficos
Autores principales:	Kien Nguyen, Paul C. Whitford
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bbd14e3cfc3844aab5e4312d31433615
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spelling	oai:doaj.org-article:bbd14e3cfc3844aab5e4312d314336152021-12-02T15:35:44ZSteric interactions lead to collective tilting motion in the ribosome during mRNA–tRNA translocation10.1038/ncomms105862041-1723https://doaj.org/article/bbd14e3cfc3844aab5e4312d314336152016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10586https://doaj.org/toc/2041-1723During protein elongation, the translocation of mRNA and tRNA molecules across the 30S ribosomal subunit is associated with large-scale motions of the 30S head domain. Here the authors carry out MD simulations to probe the associated steric interactions and identify novel tilting motions during the late stages of translocation.Kien NguyenPaul C. WhitfordNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kien Nguyen Paul C. Whitford Steric interactions lead to collective tilting motion in the ribosome during mRNA–tRNA translocation
description	During protein elongation, the translocation of mRNA and tRNA molecules across the 30S ribosomal subunit is associated with large-scale motions of the 30S head domain. Here the authors carry out MD simulations to probe the associated steric interactions and identify novel tilting motions during the late stages of translocation.
format	article
author	Kien Nguyen Paul C. Whitford
author_facet	Kien Nguyen Paul C. Whitford
author_sort	Kien Nguyen
title	Steric interactions lead to collective tilting motion in the ribosome during mRNA–tRNA translocation
title_short	Steric interactions lead to collective tilting motion in the ribosome during mRNA–tRNA translocation
title_full	Steric interactions lead to collective tilting motion in the ribosome during mRNA–tRNA translocation
title_fullStr	Steric interactions lead to collective tilting motion in the ribosome during mRNA–tRNA translocation
title_full_unstemmed	Steric interactions lead to collective tilting motion in the ribosome during mRNA–tRNA translocation
title_sort	steric interactions lead to collective tilting motion in the ribosome during mrna–trna translocation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/bbd14e3cfc3844aab5e4312d31433615
work_keys_str_mv	AT kiennguyen stericinteractionsleadtocollectivetiltingmotionintheribosomeduringmrnatrnatranslocation AT paulcwhitford stericinteractionsleadtocollectivetiltingmotionintheribosomeduringmrnatrnatranslocation
_version_	1718386498049409024

Steric interactions lead to collective tilting motion in the ribosome during mRNA–tRNA translocation

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