Salmonella enterica isolates from Western Australian rangeland goats remain susceptible to critically important antimicrobials

Abstract This study investigated faecal carriage and antimicrobial resistance (AMR) of Salmonella enterica recovered from rangeland goats. Faecal samples (n = 400) were collected at slaughter from four consignments of goats (n = 100 samples per consignment), each from one of four localities in Weste...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Khalid Al-Habsi, David Jordan, Ali Harb, Tanya Laird, Rongchang Yang, Mark O’Dea, Caroline Jacobson, David W. Miller, Una Ryan, Sam Abraham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Fecal Carriage Saintpaul ompF Gene Antimicrobial Resistance (AMR) Azithromycin (AZI) Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bbd198f968244d839af7cdfc8c20ded6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bbd198f968244d839af7cdfc8c20ded6
record_format	dspace
spelling	oai:doaj.org-article:bbd198f968244d839af7cdfc8c20ded62021-12-02T15:09:10ZSalmonella enterica isolates from Western Australian rangeland goats remain susceptible to critically important antimicrobials10.1038/s41598-018-33220-52045-2322https://doaj.org/article/bbd198f968244d839af7cdfc8c20ded62018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-33220-5https://doaj.org/toc/2045-2322Abstract This study investigated faecal carriage and antimicrobial resistance (AMR) of Salmonella enterica recovered from rangeland goats. Faecal samples (n = 400) were collected at slaughter from four consignments of goats (n = 100 samples per consignment), each from one of four localities in Western Australia. Carriage of Salmonella spp. was detected in 106 samples (26.5%; 95% CI 22.4–31.0%). The rate of faecal carriage for each consignment ranged between 23–30%. PCR assays targeting the STM2755 and STM4497 genes revealed 84.9% (90/106) of the isolates were of serovar Typhimurium. Salmonella Chester (11/106, 10.4%) and S. Saintpaul (5/106, 4.7%) were characterised at invA and ompF genes. Antimicrobial susceptibility testing demonstrated that 84.0% of isolates were susceptible to all tested (n = 13) antimicrobials. Resistance was identified to azithromycin (14.2%), tetracycline (10.4%), ampicillin (5.7%), amoxicillin–clavulanate and cefoxitin (3.8%), trimethoprim/sulfamethoxazole (1.9%), gentamicin and streptomycin (0.9%). No isolate was resistant to four or more antimicrobials, or to critically important antimicrobials such as fluoroquinolones and extended spectrum cephalosporins. This is the first study reporting AMR in Salmonella isolates from Australian rangeland goats. The rate of detection of AMR was very low, some resistance to low-importance drugs was present in the Salmonella population, despite the absence of active selection pressure.Khalid Al-HabsiDavid JordanAli HarbTanya LairdRongchang YangMark O’DeaCaroline JacobsonDavid W. MillerUna RyanSam AbrahamNature PortfolioarticleFecal CarriageSaintpaulompF GeneAntimicrobial Resistance (AMR)Azithromycin (AZI)MedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fecal Carriage Saintpaul ompF Gene Antimicrobial Resistance (AMR) Azithromycin (AZI) Medicine R Science Q
spellingShingle	Fecal Carriage Saintpaul ompF Gene Antimicrobial Resistance (AMR) Azithromycin (AZI) Medicine R Science Q Khalid Al-Habsi David Jordan Ali Harb Tanya Laird Rongchang Yang Mark O’Dea Caroline Jacobson David W. Miller Una Ryan Sam Abraham Salmonella enterica isolates from Western Australian rangeland goats remain susceptible to critically important antimicrobials
description	Abstract This study investigated faecal carriage and antimicrobial resistance (AMR) of Salmonella enterica recovered from rangeland goats. Faecal samples (n = 400) were collected at slaughter from four consignments of goats (n = 100 samples per consignment), each from one of four localities in Western Australia. Carriage of Salmonella spp. was detected in 106 samples (26.5%; 95% CI 22.4–31.0%). The rate of faecal carriage for each consignment ranged between 23–30%. PCR assays targeting the STM2755 and STM4497 genes revealed 84.9% (90/106) of the isolates were of serovar Typhimurium. Salmonella Chester (11/106, 10.4%) and S. Saintpaul (5/106, 4.7%) were characterised at invA and ompF genes. Antimicrobial susceptibility testing demonstrated that 84.0% of isolates were susceptible to all tested (n = 13) antimicrobials. Resistance was identified to azithromycin (14.2%), tetracycline (10.4%), ampicillin (5.7%), amoxicillin–clavulanate and cefoxitin (3.8%), trimethoprim/sulfamethoxazole (1.9%), gentamicin and streptomycin (0.9%). No isolate was resistant to four or more antimicrobials, or to critically important antimicrobials such as fluoroquinolones and extended spectrum cephalosporins. This is the first study reporting AMR in Salmonella isolates from Australian rangeland goats. The rate of detection of AMR was very low, some resistance to low-importance drugs was present in the Salmonella population, despite the absence of active selection pressure.
format	article
author	Khalid Al-Habsi David Jordan Ali Harb Tanya Laird Rongchang Yang Mark O’Dea Caroline Jacobson David W. Miller Una Ryan Sam Abraham
author_facet	Khalid Al-Habsi David Jordan Ali Harb Tanya Laird Rongchang Yang Mark O’Dea Caroline Jacobson David W. Miller Una Ryan Sam Abraham
author_sort	Khalid Al-Habsi
title	Salmonella enterica isolates from Western Australian rangeland goats remain susceptible to critically important antimicrobials
title_short	Salmonella enterica isolates from Western Australian rangeland goats remain susceptible to critically important antimicrobials
title_full	Salmonella enterica isolates from Western Australian rangeland goats remain susceptible to critically important antimicrobials
title_fullStr	Salmonella enterica isolates from Western Australian rangeland goats remain susceptible to critically important antimicrobials
title_full_unstemmed	Salmonella enterica isolates from Western Australian rangeland goats remain susceptible to critically important antimicrobials
title_sort	salmonella enterica isolates from western australian rangeland goats remain susceptible to critically important antimicrobials
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/bbd198f968244d839af7cdfc8c20ded6
work_keys_str_mv	AT khalidalhabsi salmonellaentericaisolatesfromwesternaustralianrangelandgoatsremainsusceptibletocriticallyimportantantimicrobials AT davidjordan salmonellaentericaisolatesfromwesternaustralianrangelandgoatsremainsusceptibletocriticallyimportantantimicrobials AT aliharb salmonellaentericaisolatesfromwesternaustralianrangelandgoatsremainsusceptibletocriticallyimportantantimicrobials AT tanyalaird salmonellaentericaisolatesfromwesternaustralianrangelandgoatsremainsusceptibletocriticallyimportantantimicrobials AT rongchangyang salmonellaentericaisolatesfromwesternaustralianrangelandgoatsremainsusceptibletocriticallyimportantantimicrobials AT markodea salmonellaentericaisolatesfromwesternaustralianrangelandgoatsremainsusceptibletocriticallyimportantantimicrobials AT carolinejacobson salmonellaentericaisolatesfromwesternaustralianrangelandgoatsremainsusceptibletocriticallyimportantantimicrobials AT davidwmiller salmonellaentericaisolatesfromwesternaustralianrangelandgoatsremainsusceptibletocriticallyimportantantimicrobials AT unaryan salmonellaentericaisolatesfromwesternaustralianrangelandgoatsremainsusceptibletocriticallyimportantantimicrobials AT samabraham salmonellaentericaisolatesfromwesternaustralianrangelandgoatsremainsusceptibletocriticallyimportantantimicrobials
_version_	1718387898552680448

Salmonella enterica isolates from Western Australian rangeland goats remain susceptible to critically important antimicrobials

Ejemplares similares