Development of a Prognostic Nomogram for Patients with Lung Adenocarcinoma in the Stages I, II, and III Based on Immune Scores

Hui Xie,1,2 Jian-Fang Zhang,3 Qing Li2,4 1Department of Radiation Oncology, Affiliated Hospital (Clinical College) of Xiangnan University, Chenzhou, 423000, Hunan Province, People’s Republic of China; 2Key Laboratory of Medical Imaging and Artificial Intelligence of Hunan Province, Chenzhou, 423000,...

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Autores principales:	Xie H, Zhang JF, Li Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	lung adenocarcinoma immune scores nomograms prognosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/bbd6f49b180e49e5b311b7222e6a8b44
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spelling	oai:doaj.org-article:bbd6f49b180e49e5b311b7222e6a8b442021-11-23T18:43:01ZDevelopment of a Prognostic Nomogram for Patients with Lung Adenocarcinoma in the Stages I, II, and III Based on Immune Scores1178-7074https://doaj.org/article/bbd6f49b180e49e5b311b7222e6a8b442021-11-01T00:00:00Zhttps://www.dovepress.com/development-of-a-prognostic-nomogram-for-patients-with-lung-adenocarci-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Hui Xie,1,2 Jian-Fang Zhang,3 Qing Li2,4 1Department of Radiation Oncology, Affiliated Hospital (Clinical College) of Xiangnan University, Chenzhou, 423000, Hunan Province, People’s Republic of China; 2Key Laboratory of Medical Imaging and Artificial Intelligence of Hunan Province, Chenzhou, 423000, Hunan Province, People’s Republic of China; 3Department of Physical Examination, Beihu Centers for Disease Control and Prevention, Chenzhou, 423000, Hunan Province, People’s Republic of China; 4Department of Interventional Vascular Surgery, Affiliated Hospital (Clinical College) of Xiangnan University, Chenzhou, 423000, Hunan Province, People’s Republic of ChinaCorrespondence: Qing LiDepartment of Interventional Vascular Surgery, Affiliated Hospital (Clinical College) of Xiangnan University, 25 Renmin Street, Chenzhou, 423000, Hunan Province, People’s Republic of ChinaTel +86 19918761912Email xnxyliqing@163.comBackground: Immunotherapy has significantly changed the treatment prospects of non-small cell lung cancer (NSCLC). However, there is no report based on immune score to predict the overall survival (OS) of lung adenocarcinoma (LUAD) in the stages I, II, and III. Therefore, this study aimed to investigate the immune score and the prognosis-related factors of LUAD and construct a nomogram to predict the prognosis.Methods: A total of 390 cases with lung adenocarcinoma in the stages I, II, and III were included in the study. The clinicopathological characteristics and immune scores of LUAD patients were downloaded from the TCGA database. Cox proportional hazards regression model was used to estimate hazard ratio (HR) and 95% confidence interval (CI). A Nomogram was composed of the Cox model and internally validated using 1000 bootstrap. The concordance index (c-index) and the calibration curves were used to evaluate the model. The decision curve analysis (DCA) was performed to evaluate the clinical practical value of the model.Results: According to the immune score, the patients were divided into low-, medium-, and high-score groups. This study showed that compared with patients with low and medium immune scores, only patients with high immune scores had significantly improved OS (HR and 95% confidence interval (CI): 0.489 [0.324‐0.737]). The C‐index for OS prediction was 0.691 (95% CI, 0.646‐0.736). The calibration curves for nomogram-predicted probabilities of 3- and 5-year survival have good ability for the calibration and discrimination.Conclusion: The high immune score was significantly correlated with better OS of patients with LUAD in the stages I, II, and III. Moreover, the nomogram of predicting prognosis may help assess the survival of LUAD patients.Keywords: lung adenocarcinoma, immune scores, nomograms, prognosisXie HZhang JFLi QDove Medical Pressarticlelung adenocarcinomaimmune scoresnomogramsprognosisMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 8677-8688 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung adenocarcinoma immune scores nomograms prognosis Medicine (General) R5-920
spellingShingle	lung adenocarcinoma immune scores nomograms prognosis Medicine (General) R5-920 Xie H Zhang JF Li Q Development of a Prognostic Nomogram for Patients with Lung Adenocarcinoma in the Stages I, II, and III Based on Immune Scores
description	Hui Xie,1,2 Jian-Fang Zhang,3 Qing Li2,4 1Department of Radiation Oncology, Affiliated Hospital (Clinical College) of Xiangnan University, Chenzhou, 423000, Hunan Province, People’s Republic of China; 2Key Laboratory of Medical Imaging and Artificial Intelligence of Hunan Province, Chenzhou, 423000, Hunan Province, People’s Republic of China; 3Department of Physical Examination, Beihu Centers for Disease Control and Prevention, Chenzhou, 423000, Hunan Province, People’s Republic of China; 4Department of Interventional Vascular Surgery, Affiliated Hospital (Clinical College) of Xiangnan University, Chenzhou, 423000, Hunan Province, People’s Republic of ChinaCorrespondence: Qing LiDepartment of Interventional Vascular Surgery, Affiliated Hospital (Clinical College) of Xiangnan University, 25 Renmin Street, Chenzhou, 423000, Hunan Province, People’s Republic of ChinaTel +86 19918761912Email xnxyliqing@163.comBackground: Immunotherapy has significantly changed the treatment prospects of non-small cell lung cancer (NSCLC). However, there is no report based on immune score to predict the overall survival (OS) of lung adenocarcinoma (LUAD) in the stages I, II, and III. Therefore, this study aimed to investigate the immune score and the prognosis-related factors of LUAD and construct a nomogram to predict the prognosis.Methods: A total of 390 cases with lung adenocarcinoma in the stages I, II, and III were included in the study. The clinicopathological characteristics and immune scores of LUAD patients were downloaded from the TCGA database. Cox proportional hazards regression model was used to estimate hazard ratio (HR) and 95% confidence interval (CI). A Nomogram was composed of the Cox model and internally validated using 1000 bootstrap. The concordance index (c-index) and the calibration curves were used to evaluate the model. The decision curve analysis (DCA) was performed to evaluate the clinical practical value of the model.Results: According to the immune score, the patients were divided into low-, medium-, and high-score groups. This study showed that compared with patients with low and medium immune scores, only patients with high immune scores had significantly improved OS (HR and 95% confidence interval (CI): 0.489 [0.324‐0.737]). The C‐index for OS prediction was 0.691 (95% CI, 0.646‐0.736). The calibration curves for nomogram-predicted probabilities of 3- and 5-year survival have good ability for the calibration and discrimination.Conclusion: The high immune score was significantly correlated with better OS of patients with LUAD in the stages I, II, and III. Moreover, the nomogram of predicting prognosis may help assess the survival of LUAD patients.Keywords: lung adenocarcinoma, immune scores, nomograms, prognosis
format	article
author	Xie H Zhang JF Li Q
author_facet	Xie H Zhang JF Li Q
author_sort	Xie H
title	Development of a Prognostic Nomogram for Patients with Lung Adenocarcinoma in the Stages I, II, and III Based on Immune Scores
title_short	Development of a Prognostic Nomogram for Patients with Lung Adenocarcinoma in the Stages I, II, and III Based on Immune Scores
title_full	Development of a Prognostic Nomogram for Patients with Lung Adenocarcinoma in the Stages I, II, and III Based on Immune Scores
title_fullStr	Development of a Prognostic Nomogram for Patients with Lung Adenocarcinoma in the Stages I, II, and III Based on Immune Scores
title_full_unstemmed	Development of a Prognostic Nomogram for Patients with Lung Adenocarcinoma in the Stages I, II, and III Based on Immune Scores
title_sort	development of a prognostic nomogram for patients with lung adenocarcinoma in the stages i, ii, and iii based on immune scores
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/bbd6f49b180e49e5b311b7222e6a8b44
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Development of a Prognostic Nomogram for Patients with Lung Adenocarcinoma in the Stages I, II, and III Based on Immune Scores

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