Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome

Proteasomal degradation is required for the progression of spermatogenesis. Here the authors demonstrate that deletion of the testis-specific proteasome subunit PMSA8 leads to stabilization of the meiotic proteins RAD51 and RPA1 and a spermatogenic block at M-phase of meiosis I.

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Autores principales:	Qianting Zhang, Shu-Yan Ji, Kiran Busayavalasa, Jingchen Shao, Chao Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bbd728fcf8bf465bac52d2ef2f0168b0
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spelling	oai:doaj.org-article:bbd728fcf8bf465bac52d2ef2f0168b02021-12-02T15:35:48ZMeiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome10.1038/s41467-019-11346-y2041-1723https://doaj.org/article/bbd728fcf8bf465bac52d2ef2f0168b02019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11346-yhttps://doaj.org/toc/2041-1723Proteasomal degradation is required for the progression of spermatogenesis. Here the authors demonstrate that deletion of the testis-specific proteasome subunit PMSA8 leads to stabilization of the meiotic proteins RAD51 and RPA1 and a spermatogenic block at M-phase of meiosis I.Qianting ZhangShu-Yan JiKiran BusayavalasaJingchen ShaoChao YuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qianting Zhang Shu-Yan Ji Kiran Busayavalasa Jingchen Shao Chao Yu Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome
description	Proteasomal degradation is required for the progression of spermatogenesis. Here the authors demonstrate that deletion of the testis-specific proteasome subunit PMSA8 leads to stabilization of the meiotic proteins RAD51 and RPA1 and a spermatogenic block at M-phase of meiosis I.
format	article
author	Qianting Zhang Shu-Yan Ji Kiran Busayavalasa Jingchen Shao Chao Yu
author_facet	Qianting Zhang Shu-Yan Ji Kiran Busayavalasa Jingchen Shao Chao Yu
author_sort	Qianting Zhang
title	Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome
title_short	Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome
title_full	Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome
title_fullStr	Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome
title_full_unstemmed	Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome
title_sort	meiosis i progression in spermatogenesis requires a type of testis-specific 20s core proteasome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bbd728fcf8bf465bac52d2ef2f0168b0
work_keys_str_mv	AT qiantingzhang meiosisiprogressioninspermatogenesisrequiresatypeoftestisspecific20scoreproteasome AT shuyanji meiosisiprogressioninspermatogenesisrequiresatypeoftestisspecific20scoreproteasome AT kiranbusayavalasa meiosisiprogressioninspermatogenesisrequiresatypeoftestisspecific20scoreproteasome AT jingchenshao meiosisiprogressioninspermatogenesisrequiresatypeoftestisspecific20scoreproteasome AT chaoyu meiosisiprogressioninspermatogenesisrequiresatypeoftestisspecific20scoreproteasome
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Meiosis I progression in spermatogenesis requires a type of testis-specific 20S core proteasome

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