Serum and urine 1H NMR-based metabolomics in the diagnosis of selected thyroid diseases

Abstract Early detection of nodular thyroid diseases including thyroid cancer is still primarily based on invasive procedures such as fine-needle aspiration biopsy. Therefore, there is a strong need for development of new diagnostic methods that could provide clinically useful information regarding...

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Autores principales:	Wojciech Wojtowicz, Adam Zabek, Stanislaw Deja, Tomasz Dawiskiba, Dorota Pawelka, Mateusz Glod, Waldemar Balcerzak, Piotr Mlynarz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bbd8eac53b29482a8dbefca07decd340
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spelling	oai:doaj.org-article:bbd8eac53b29482a8dbefca07decd3402021-12-02T16:06:34ZSerum and urine 1H NMR-based metabolomics in the diagnosis of selected thyroid diseases10.1038/s41598-017-09203-32045-2322https://doaj.org/article/bbd8eac53b29482a8dbefca07decd3402017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09203-3https://doaj.org/toc/2045-2322Abstract Early detection of nodular thyroid diseases including thyroid cancer is still primarily based on invasive procedures such as fine-needle aspiration biopsy. Therefore, there is a strong need for development of new diagnostic methods that could provide clinically useful information regarding thyroid nodular lesions in a non-invasive way. In this study we investigated 1H NMR based metabolic profiles of paired urine and blood serum samples, that were obtained from healthy individuals and patients with nodular thyroid diseases. Estimation of predictive potential of metabolites was evaluated using chemometric methods and revealed that both urine and serum carry information sufficient to distinguish between patients with nodular lesions and healthy individuals. Data fusion allowed to further improve prediction quality of the models. However, stratification of tumor types and their differentiation in relation to each other was not possible.Wojciech WojtowiczAdam ZabekStanislaw DejaTomasz DawiskibaDorota PawelkaMateusz GlodWaldemar BalcerzakPiotr MlynarzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wojciech Wojtowicz Adam Zabek Stanislaw Deja Tomasz Dawiskiba Dorota Pawelka Mateusz Glod Waldemar Balcerzak Piotr Mlynarz Serum and urine 1H NMR-based metabolomics in the diagnosis of selected thyroid diseases
description	Abstract Early detection of nodular thyroid diseases including thyroid cancer is still primarily based on invasive procedures such as fine-needle aspiration biopsy. Therefore, there is a strong need for development of new diagnostic methods that could provide clinically useful information regarding thyroid nodular lesions in a non-invasive way. In this study we investigated 1H NMR based metabolic profiles of paired urine and blood serum samples, that were obtained from healthy individuals and patients with nodular thyroid diseases. Estimation of predictive potential of metabolites was evaluated using chemometric methods and revealed that both urine and serum carry information sufficient to distinguish between patients with nodular lesions and healthy individuals. Data fusion allowed to further improve prediction quality of the models. However, stratification of tumor types and their differentiation in relation to each other was not possible.
format	article
author	Wojciech Wojtowicz Adam Zabek Stanislaw Deja Tomasz Dawiskiba Dorota Pawelka Mateusz Glod Waldemar Balcerzak Piotr Mlynarz
author_facet	Wojciech Wojtowicz Adam Zabek Stanislaw Deja Tomasz Dawiskiba Dorota Pawelka Mateusz Glod Waldemar Balcerzak Piotr Mlynarz
author_sort	Wojciech Wojtowicz
title	Serum and urine 1H NMR-based metabolomics in the diagnosis of selected thyroid diseases
title_short	Serum and urine 1H NMR-based metabolomics in the diagnosis of selected thyroid diseases
title_full	Serum and urine 1H NMR-based metabolomics in the diagnosis of selected thyroid diseases
title_fullStr	Serum and urine 1H NMR-based metabolomics in the diagnosis of selected thyroid diseases
title_full_unstemmed	Serum and urine 1H NMR-based metabolomics in the diagnosis of selected thyroid diseases
title_sort	serum and urine 1h nmr-based metabolomics in the diagnosis of selected thyroid diseases
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bbd8eac53b29482a8dbefca07decd340
work_keys_str_mv	AT wojciechwojtowicz serumandurine1hnmrbasedmetabolomicsinthediagnosisofselectedthyroiddiseases AT adamzabek serumandurine1hnmrbasedmetabolomicsinthediagnosisofselectedthyroiddiseases AT stanislawdeja serumandurine1hnmrbasedmetabolomicsinthediagnosisofselectedthyroiddiseases AT tomaszdawiskiba serumandurine1hnmrbasedmetabolomicsinthediagnosisofselectedthyroiddiseases AT dorotapawelka serumandurine1hnmrbasedmetabolomicsinthediagnosisofselectedthyroiddiseases AT mateuszglod serumandurine1hnmrbasedmetabolomicsinthediagnosisofselectedthyroiddiseases AT waldemarbalcerzak serumandurine1hnmrbasedmetabolomicsinthediagnosisofselectedthyroiddiseases AT piotrmlynarz serumandurine1hnmrbasedmetabolomicsinthediagnosisofselectedthyroiddiseases
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Serum and urine 1H NMR-based metabolomics in the diagnosis of selected thyroid diseases

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