Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration

Carrasco et al. report a method that can predict the lipid nanoparticles (LNP) pKa from the structure of the ionizable lipid. They investigate the delivery efficiency for intramuscular and intravascular administration and propose design principles to limit off-target systemic distribution and expres...

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Autores principales:	Manuel J. Carrasco, Suman Alishetty, Mohamad-Gabriel Alameh, Hooda Said, Lacey Wright, Mikell Paige, Ousamah Soliman, Drew Weissman, Thomas E. Cleveland, Alexander Grishaev, Michael D. Buschmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bbdbf3686db74c9385304e3b47673ec7
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spelling	oai:doaj.org-article:bbdbf3686db74c9385304e3b47673ec72021-12-02T16:43:38ZIonization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration10.1038/s42003-021-02441-22399-3642https://doaj.org/article/bbdbf3686db74c9385304e3b47673ec72021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02441-2https://doaj.org/toc/2399-3642Carrasco et al. report a method that can predict the lipid nanoparticles (LNP) pKa from the structure of the ionizable lipid. They investigate the delivery efficiency for intramuscular and intravascular administration and propose design principles to limit off-target systemic distribution and expression for mRNA LNP vaccines.Manuel J. CarrascoSuman AlishettyMohamad-Gabriel AlamehHooda SaidLacey WrightMikell PaigeOusamah SolimanDrew WeissmanThomas E. ClevelandAlexander GrishaevMichael D. BuschmannNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Manuel J. Carrasco Suman Alishetty Mohamad-Gabriel Alameh Hooda Said Lacey Wright Mikell Paige Ousamah Soliman Drew Weissman Thomas E. Cleveland Alexander Grishaev Michael D. Buschmann Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration
description	Carrasco et al. report a method that can predict the lipid nanoparticles (LNP) pKa from the structure of the ionizable lipid. They investigate the delivery efficiency for intramuscular and intravascular administration and propose design principles to limit off-target systemic distribution and expression for mRNA LNP vaccines.
format	article
author	Manuel J. Carrasco Suman Alishetty Mohamad-Gabriel Alameh Hooda Said Lacey Wright Mikell Paige Ousamah Soliman Drew Weissman Thomas E. Cleveland Alexander Grishaev Michael D. Buschmann
author_facet	Manuel J. Carrasco Suman Alishetty Mohamad-Gabriel Alameh Hooda Said Lacey Wright Mikell Paige Ousamah Soliman Drew Weissman Thomas E. Cleveland Alexander Grishaev Michael D. Buschmann
author_sort	Manuel J. Carrasco
title	Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration
title_short	Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration
title_full	Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration
title_fullStr	Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration
title_full_unstemmed	Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration
title_sort	ionization and structural properties of mrna lipid nanoparticles influence expression in intramuscular and intravascular administration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bbdbf3686db74c9385304e3b47673ec7
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Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration

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