ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation

The chaperone Hsp70 has a dual role, promoting both protein refolding and protein degradation. Seo and Park et al. show that Hsp70 acetylation enhances protein refolding after stress, and that subsequent deacetylation progressively promotes ubiquitin ligase binding and protein degradation.

Guardado en:

Detalles Bibliográficos
Autores principales:	Ji Hae Seo, Ji-Hyeon Park, Eun Ji Lee, Tam Thuy Lu Vo, Hoon Choi, Jun Yong Kim, Jae Kyung Jang, Hee-Jun Wee, Hye Shin Lee, Se Hwan Jang, Zee Yong Park, Jaeho Jeong, Kong-Joo Lee, Seung-Hyeon Seok, Jin Young Park, Bong Jin Lee, Mi-Ni Lee, Goo Taeg Oh, Kyu-Won Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bbe3b18cb62b4560996ac9f25bb15fdb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bbe3b18cb62b4560996ac9f25bb15fdb
record_format	dspace
spelling	oai:doaj.org-article:bbe3b18cb62b4560996ac9f25bb15fdb2021-12-02T14:39:29ZARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation10.1038/ncomms128822041-1723https://doaj.org/article/bbe3b18cb62b4560996ac9f25bb15fdb2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12882https://doaj.org/toc/2041-1723The chaperone Hsp70 has a dual role, promoting both protein refolding and protein degradation. Seo and Park et al. show that Hsp70 acetylation enhances protein refolding after stress, and that subsequent deacetylation progressively promotes ubiquitin ligase binding and protein degradation.Ji Hae SeoJi-Hyeon ParkEun Ji LeeTam Thuy Lu VoHoon ChoiJun Yong KimJae Kyung JangHee-Jun WeeHye Shin LeeSe Hwan JangZee Yong ParkJaeho JeongKong-Joo LeeSeung-Hyeon SeokJin Young ParkBong Jin LeeMi-Ni LeeGoo Taeg OhKyu-Won KimNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ji Hae Seo Ji-Hyeon Park Eun Ji Lee Tam Thuy Lu Vo Hoon Choi Jun Yong Kim Jae Kyung Jang Hee-Jun Wee Hye Shin Lee Se Hwan Jang Zee Yong Park Jaeho Jeong Kong-Joo Lee Seung-Hyeon Seok Jin Young Park Bong Jin Lee Mi-Ni Lee Goo Taeg Oh Kyu-Won Kim ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation
description	The chaperone Hsp70 has a dual role, promoting both protein refolding and protein degradation. Seo and Park et al. show that Hsp70 acetylation enhances protein refolding after stress, and that subsequent deacetylation progressively promotes ubiquitin ligase binding and protein degradation.
format	article
author	Ji Hae Seo Ji-Hyeon Park Eun Ji Lee Tam Thuy Lu Vo Hoon Choi Jun Yong Kim Jae Kyung Jang Hee-Jun Wee Hye Shin Lee Se Hwan Jang Zee Yong Park Jaeho Jeong Kong-Joo Lee Seung-Hyeon Seok Jin Young Park Bong Jin Lee Mi-Ni Lee Goo Taeg Oh Kyu-Won Kim
author_facet	Ji Hae Seo Ji-Hyeon Park Eun Ji Lee Tam Thuy Lu Vo Hoon Choi Jun Yong Kim Jae Kyung Jang Hee-Jun Wee Hye Shin Lee Se Hwan Jang Zee Yong Park Jaeho Jeong Kong-Joo Lee Seung-Hyeon Seok Jin Young Park Bong Jin Lee Mi-Ni Lee Goo Taeg Oh Kyu-Won Kim
author_sort	Ji Hae Seo
title	ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation
title_short	ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation
title_full	ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation
title_fullStr	ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation
title_full_unstemmed	ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation
title_sort	ard1-mediated hsp70 acetylation balances stress-induced protein refolding and degradation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/bbe3b18cb62b4560996ac9f25bb15fdb
work_keys_str_mv	AT jihaeseo ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT jihyeonpark ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT eunjilee ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT tamthuyluvo ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT hoonchoi ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT junyongkim ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT jaekyungjang ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT heejunwee ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT hyeshinlee ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT sehwanjang ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT zeeyongpark ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT jaehojeong ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT kongjoolee ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT seunghyeonseok ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT jinyoungpark ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT bongjinlee ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT minilee ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT gootaegoh ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation AT kyuwonkim ard1mediatedhsp70acetylationbalancesstressinducedproteinrefoldinganddegradation
_version_	1718390614240788480

ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation

Ejemplares similares