ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation

ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation

The chaperone Hsp70 has a dual role, promoting both protein refolding and protein degradation. Seo and Park et al. show that Hsp70 acetylation enhances protein refolding after stress, and that subsequent deacetylation progressively promotes ubiquitin ligase binding and protein degradation.

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Autores principales: Ji Hae Seo, Ji-Hyeon Park, Eun Ji Lee, Tam Thuy Lu Vo, Hoon Choi, Jun Yong Kim, Jae Kyung Jang, Hee-Jun Wee, Hye Shin Lee, Se Hwan Jang, Zee Yong Park, Jaeho Jeong, Kong-Joo Lee, Seung-Hyeon Seok, Jin Young Park, Bong Jin Lee, Mi-Ni Lee, Goo Taeg Oh, Kyu-Won Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/bbe3b18cb62b4560996ac9f25bb15fdb
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https://doaj.org/article/bbe3b18cb62b4560996ac9f25bb15fdb

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