Drug-Induced Movement Disorders and Its Associated Factors Among Patients Attending Treatment at Public Hospitals in Eastern Ethiopia

Tadesse Misgana,1 Niguse Yigzaw,2 Getachew Asfaw3 1Department of Psychiatry, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 2Department of Psychiatry, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia; 3Research and Training Department, Ama...

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Autores principales:	Misgana T, Yigzaw N, Asfaw G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	akathisia pseudo-parkinsonism tardive dyskinesia tardive dystonia movement disorders ethiopia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/bbe8a9156dcb401aa8921d9150d96aff
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spelling	oai:doaj.org-article:bbe8a9156dcb401aa8921d9150d96aff2021-12-02T10:15:25ZDrug-Induced Movement Disorders and Its Associated Factors Among Patients Attending Treatment at Public Hospitals in Eastern Ethiopia1178-2021https://doaj.org/article/bbe8a9156dcb401aa8921d9150d96aff2020-08-01T00:00:00Zhttps://www.dovepress.com/drug-induced-movement-disorders-and-its-associated-factors-among-patie-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Tadesse Misgana,1 Niguse Yigzaw,2 Getachew Asfaw3 1Department of Psychiatry, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 2Department of Psychiatry, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia; 3Research and Training Department, Amanuel Mental Specialized Hospital, Addis Ababa, EthiopiaCorrespondence: Tadesse Misgana Tel +251 923 100 463Email tadessemisgana25@gmail.comBackground: Antipsychotic medications have both beneficial and undesired effects at a dose used for treatment purposes. Among undesired effects caused by antipsychotics, movement disorders are prevalent. However, there is no study done to determine the prevalence of movement disorders that occurred due to antipsychotics and their determinants in eastern Ethiopia.Objective: This study aimed to find out the prevalence of drug-induced movement disorders and its determinants among patients who had been on follow-up at public hospitals in eastern Ethiopia.Methods: A cross-sectional study was conducted from May to June 2018 at HFSUH and Jugal hospital. Extrapyramidal symptom rating scale (ESRS) was used to identify patients with drug-induced movement disorders in a sample of 411 outpatients. A systematic random sampling method was used to select the sample. Logistic regression was done to identify factors associated.Results: A drug-induced movement disorder was found in 44% of the participants: Of this, 27.3% had drug-induced pseudo-Parkinsonism, 21.2% had drug-induced akathisia, 9.5% had drug-induced tardive dyskinesia, and 3.4% had drug-induced tardive dystonia. Being female was associated with pseudo-Parkinsonism (AOR=3.6, 95% CI: 2.03, 6.35), akathisia (AOR=4.9, 95% CI: 2.73, 8.78), and tardive dyskinesia (AOR=2.51, 95% CI: 1.08, 5.86) and being male with tardive dystonia (AOR=4.6, 95% CI: 1.8, 18.5). Alcohol use was associated with tardive dyskinesia (AOR= 5.89, 95% CI: 2.20, 15.69).Conclusion: Drug-induced movement disorder in this study was high and nearly half of patients on antipsychotic treatment were experiencing it. Age, sex, and doses of antipsychotics were factors associated with all of the types of drug-induced movement disorders.Keywords: akathisia, pseudo-parkinsonism, tardive dyskinesia, tardive dystonia, movement disorders, EthiopiaMisgana TYigzaw NAsfaw GDove Medical Pressarticleakathisiapseudo-parkinsonismtardive dyskinesiatardive dystoniamovement disordersethiopiaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1987-1995 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	akathisia pseudo-parkinsonism tardive dyskinesia tardive dystonia movement disorders ethiopia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	akathisia pseudo-parkinsonism tardive dyskinesia tardive dystonia movement disorders ethiopia Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Misgana T Yigzaw N Asfaw G Drug-Induced Movement Disorders and Its Associated Factors Among Patients Attending Treatment at Public Hospitals in Eastern Ethiopia
description	Tadesse Misgana,1 Niguse Yigzaw,2 Getachew Asfaw3 1Department of Psychiatry, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 2Department of Psychiatry, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia; 3Research and Training Department, Amanuel Mental Specialized Hospital, Addis Ababa, EthiopiaCorrespondence: Tadesse Misgana Tel +251 923 100 463Email tadessemisgana25@gmail.comBackground: Antipsychotic medications have both beneficial and undesired effects at a dose used for treatment purposes. Among undesired effects caused by antipsychotics, movement disorders are prevalent. However, there is no study done to determine the prevalence of movement disorders that occurred due to antipsychotics and their determinants in eastern Ethiopia.Objective: This study aimed to find out the prevalence of drug-induced movement disorders and its determinants among patients who had been on follow-up at public hospitals in eastern Ethiopia.Methods: A cross-sectional study was conducted from May to June 2018 at HFSUH and Jugal hospital. Extrapyramidal symptom rating scale (ESRS) was used to identify patients with drug-induced movement disorders in a sample of 411 outpatients. A systematic random sampling method was used to select the sample. Logistic regression was done to identify factors associated.Results: A drug-induced movement disorder was found in 44% of the participants: Of this, 27.3% had drug-induced pseudo-Parkinsonism, 21.2% had drug-induced akathisia, 9.5% had drug-induced tardive dyskinesia, and 3.4% had drug-induced tardive dystonia. Being female was associated with pseudo-Parkinsonism (AOR=3.6, 95% CI: 2.03, 6.35), akathisia (AOR=4.9, 95% CI: 2.73, 8.78), and tardive dyskinesia (AOR=2.51, 95% CI: 1.08, 5.86) and being male with tardive dystonia (AOR=4.6, 95% CI: 1.8, 18.5). Alcohol use was associated with tardive dyskinesia (AOR= 5.89, 95% CI: 2.20, 15.69).Conclusion: Drug-induced movement disorder in this study was high and nearly half of patients on antipsychotic treatment were experiencing it. Age, sex, and doses of antipsychotics were factors associated with all of the types of drug-induced movement disorders.Keywords: akathisia, pseudo-parkinsonism, tardive dyskinesia, tardive dystonia, movement disorders, Ethiopia
format	article
author	Misgana T Yigzaw N Asfaw G
author_facet	Misgana T Yigzaw N Asfaw G
author_sort	Misgana T
title	Drug-Induced Movement Disorders and Its Associated Factors Among Patients Attending Treatment at Public Hospitals in Eastern Ethiopia
title_short	Drug-Induced Movement Disorders and Its Associated Factors Among Patients Attending Treatment at Public Hospitals in Eastern Ethiopia
title_full	Drug-Induced Movement Disorders and Its Associated Factors Among Patients Attending Treatment at Public Hospitals in Eastern Ethiopia
title_fullStr	Drug-Induced Movement Disorders and Its Associated Factors Among Patients Attending Treatment at Public Hospitals in Eastern Ethiopia
title_full_unstemmed	Drug-Induced Movement Disorders and Its Associated Factors Among Patients Attending Treatment at Public Hospitals in Eastern Ethiopia
title_sort	drug-induced movement disorders and its associated factors among patients attending treatment at public hospitals in eastern ethiopia
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/bbe8a9156dcb401aa8921d9150d96aff
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Drug-Induced Movement Disorders and Its Associated Factors Among Patients Attending Treatment at Public Hospitals in Eastern Ethiopia

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