Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8

Schwann cells (SCs) can acquire a repair phenotype following nerve injury. Here, the authors show that stromal SCs in ganglioneuromas express nerve-repair genes. Importantly, neuroblastoma cells respond to repair-related SCs increasing neuronal differentiation and reducing proliferation via EGFL8.

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Autores principales:	Tamara Weiss, Sabine Taschner-Mandl, Lukas Janker, Andrea Bileck, Fikret Rifatbegovic, Florian Kromp, Helena Sorger, Maximilian O. Kauer, Christian Frech, Reinhard Windhager, Christopher Gerner, Peter F. Ambros, Inge M. Ambros
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bbebc8510b0142cda49d7e4b7259747d
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spelling	oai:doaj.org-article:bbebc8510b0142cda49d7e4b7259747d2021-12-02T13:15:51ZSchwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 810.1038/s41467-021-21859-02041-1723https://doaj.org/article/bbebc8510b0142cda49d7e4b7259747d2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21859-0https://doaj.org/toc/2041-1723Schwann cells (SCs) can acquire a repair phenotype following nerve injury. Here, the authors show that stromal SCs in ganglioneuromas express nerve-repair genes. Importantly, neuroblastoma cells respond to repair-related SCs increasing neuronal differentiation and reducing proliferation via EGFL8.Tamara WeissSabine Taschner-MandlLukas JankerAndrea BileckFikret RifatbegovicFlorian KrompHelena SorgerMaximilian O. KauerChristian FrechReinhard WindhagerChristopher GernerPeter F. AmbrosInge M. AmbrosNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tamara Weiss Sabine Taschner-Mandl Lukas Janker Andrea Bileck Fikret Rifatbegovic Florian Kromp Helena Sorger Maximilian O. Kauer Christian Frech Reinhard Windhager Christopher Gerner Peter F. Ambros Inge M. Ambros Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
description	Schwann cells (SCs) can acquire a repair phenotype following nerve injury. Here, the authors show that stromal SCs in ganglioneuromas express nerve-repair genes. Importantly, neuroblastoma cells respond to repair-related SCs increasing neuronal differentiation and reducing proliferation via EGFL8.
format	article
author	Tamara Weiss Sabine Taschner-Mandl Lukas Janker Andrea Bileck Fikret Rifatbegovic Florian Kromp Helena Sorger Maximilian O. Kauer Christian Frech Reinhard Windhager Christopher Gerner Peter F. Ambros Inge M. Ambros
author_facet	Tamara Weiss Sabine Taschner-Mandl Lukas Janker Andrea Bileck Fikret Rifatbegovic Florian Kromp Helena Sorger Maximilian O. Kauer Christian Frech Reinhard Windhager Christopher Gerner Peter F. Ambros Inge M. Ambros
author_sort	Tamara Weiss
title	Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
title_short	Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
title_full	Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
title_fullStr	Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
title_full_unstemmed	Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
title_sort	schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bbebc8510b0142cda49d7e4b7259747d
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Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8

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