Effect of nano-hydroxyapatite and ozone on approximal initial caries: a randomized clinical trial

Abstract The aim of the study was to assess the efficacy of three methods of enamel remineralization on initial approximal caries: (1) a nano-hydroxyapatite gel, (2) gaseous ozone therapy, (3) combination of a nano-hydroxyapatite gel and ozone. Patients (n = 92, age 20–30 years) with initial approxi...

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Autores principales:	Katarzyna Grocholewicz, Grażyna Matkowska-Cichocka, Piotr Makowiecki, Agnieszka Droździk, Halina Ey-Chmielewska, Anna Dziewulska, Małgorzata Tomasik, Grzegorz Trybek, Joanna Janiszewska-Olszowska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bbece7c48267490cb47ad93c9de851e7
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spelling	oai:doaj.org-article:bbece7c48267490cb47ad93c9de851e72021-12-02T16:24:49ZEffect of nano-hydroxyapatite and ozone on approximal initial caries: a randomized clinical trial10.1038/s41598-020-67885-82045-2322https://doaj.org/article/bbece7c48267490cb47ad93c9de851e72020-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-67885-8https://doaj.org/toc/2045-2322Abstract The aim of the study was to assess the efficacy of three methods of enamel remineralization on initial approximal caries: (1) a nano-hydroxyapatite gel, (2) gaseous ozone therapy, (3) combination of a nano-hydroxyapatite gel and ozone. Patients (n = 92, age 20–30 years) with initial approximal enamel lesions on premolar and molar teeth (n = 546) were randomly allocated to three groups subjected to a 6-months treatment: Group I: domestic nano-hydroxyapatite remineralizing gel, group II: in-office ozone therapy, group III: both domestic remineralizing gel and ozone therapy. Caries lesions were assessed on bitewing radiographs at baseline, after 1 year and after 2 years. At one-year follow-up, the smallest rate of lesions with remineralisation (36.5%) was found in group I, and the highest (69.3%)—in group III. In group III a significant remineralisation was noticed in after 1 year and then a demineralisation after 2 years. Thus nano-hydroxyapatite gel and ozone therapy exert some capacities to remineralize approximal enamel and dentine subsurface lesions of premolar and molar teeth. Moreover, the combination of both methods produces the best effect compared to nano-hydroxyapatite or ozone therapy applied alone. However, the treatment should be continued for a long time in order to achieve nonrestorative recovery of caries.Katarzyna GrocholewiczGrażyna Matkowska-CichockaPiotr MakowieckiAgnieszka DroździkHalina Ey-ChmielewskaAnna DziewulskaMałgorzata TomasikGrzegorz TrybekJoanna Janiszewska-OlszowskaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katarzyna Grocholewicz Grażyna Matkowska-Cichocka Piotr Makowiecki Agnieszka Droździk Halina Ey-Chmielewska Anna Dziewulska Małgorzata Tomasik Grzegorz Trybek Joanna Janiszewska-Olszowska Effect of nano-hydroxyapatite and ozone on approximal initial caries: a randomized clinical trial
description	Abstract The aim of the study was to assess the efficacy of three methods of enamel remineralization on initial approximal caries: (1) a nano-hydroxyapatite gel, (2) gaseous ozone therapy, (3) combination of a nano-hydroxyapatite gel and ozone. Patients (n = 92, age 20–30 years) with initial approximal enamel lesions on premolar and molar teeth (n = 546) were randomly allocated to three groups subjected to a 6-months treatment: Group I: domestic nano-hydroxyapatite remineralizing gel, group II: in-office ozone therapy, group III: both domestic remineralizing gel and ozone therapy. Caries lesions were assessed on bitewing radiographs at baseline, after 1 year and after 2 years. At one-year follow-up, the smallest rate of lesions with remineralisation (36.5%) was found in group I, and the highest (69.3%)—in group III. In group III a significant remineralisation was noticed in after 1 year and then a demineralisation after 2 years. Thus nano-hydroxyapatite gel and ozone therapy exert some capacities to remineralize approximal enamel and dentine subsurface lesions of premolar and molar teeth. Moreover, the combination of both methods produces the best effect compared to nano-hydroxyapatite or ozone therapy applied alone. However, the treatment should be continued for a long time in order to achieve nonrestorative recovery of caries.
format	article
author	Katarzyna Grocholewicz Grażyna Matkowska-Cichocka Piotr Makowiecki Agnieszka Droździk Halina Ey-Chmielewska Anna Dziewulska Małgorzata Tomasik Grzegorz Trybek Joanna Janiszewska-Olszowska
author_facet	Katarzyna Grocholewicz Grażyna Matkowska-Cichocka Piotr Makowiecki Agnieszka Droździk Halina Ey-Chmielewska Anna Dziewulska Małgorzata Tomasik Grzegorz Trybek Joanna Janiszewska-Olszowska
author_sort	Katarzyna Grocholewicz
title	Effect of nano-hydroxyapatite and ozone on approximal initial caries: a randomized clinical trial
title_short	Effect of nano-hydroxyapatite and ozone on approximal initial caries: a randomized clinical trial
title_full	Effect of nano-hydroxyapatite and ozone on approximal initial caries: a randomized clinical trial
title_fullStr	Effect of nano-hydroxyapatite and ozone on approximal initial caries: a randomized clinical trial
title_full_unstemmed	Effect of nano-hydroxyapatite and ozone on approximal initial caries: a randomized clinical trial
title_sort	effect of nano-hydroxyapatite and ozone on approximal initial caries: a randomized clinical trial
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bbece7c48267490cb47ad93c9de851e7
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Effect of nano-hydroxyapatite and ozone on approximal initial caries: a randomized clinical trial

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