Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens

Mutations in the homologous recombination proteins BRCA1 and BRCA2 can sensitize cells to treatment with inhibitors of poly-ADP-ribose polymerase 1 (PARPi), but resistance to the treatment can occur. Here the authors by genome-wide CRISPR knockout and activation screens reveal novel pathways of PARP...

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Autores principales:	Kristen E. Clements, Emily M. Schleicher, Tanay Thakar, Anastasia Hale, Ashna Dhoonmoon, Nathanial J. Tolman, Anchal Sharma, Xinwen Liang, Yuka Imamura Kawasawa, Claudia M. Nicolae, Hong-Gang Wang, Subhajyoti De, George-Lucian Moldovan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bbee1b004cdc4bdebae2ddc9b6d5a3f3
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spelling	oai:doaj.org-article:bbee1b004cdc4bdebae2ddc9b6d5a3f32021-12-02T17:31:24ZIdentification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens10.1038/s41467-020-19961-w2041-1723https://doaj.org/article/bbee1b004cdc4bdebae2ddc9b6d5a3f32020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19961-whttps://doaj.org/toc/2041-1723Mutations in the homologous recombination proteins BRCA1 and BRCA2 can sensitize cells to treatment with inhibitors of poly-ADP-ribose polymerase 1 (PARPi), but resistance to the treatment can occur. Here the authors by genome-wide CRISPR knockout and activation screens reveal novel pathways of PARPi resistance in BRCA2-deficient cells.Kristen E. ClementsEmily M. SchleicherTanay ThakarAnastasia HaleAshna DhoonmoonNathanial J. TolmanAnchal SharmaXinwen LiangYuka Imamura KawasawaClaudia M. NicolaeHong-Gang WangSubhajyoti DeGeorge-Lucian MoldovanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kristen E. Clements Emily M. Schleicher Tanay Thakar Anastasia Hale Ashna Dhoonmoon Nathanial J. Tolman Anchal Sharma Xinwen Liang Yuka Imamura Kawasawa Claudia M. Nicolae Hong-Gang Wang Subhajyoti De George-Lucian Moldovan Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens
description	Mutations in the homologous recombination proteins BRCA1 and BRCA2 can sensitize cells to treatment with inhibitors of poly-ADP-ribose polymerase 1 (PARPi), but resistance to the treatment can occur. Here the authors by genome-wide CRISPR knockout and activation screens reveal novel pathways of PARPi resistance in BRCA2-deficient cells.
format	article
author	Kristen E. Clements Emily M. Schleicher Tanay Thakar Anastasia Hale Ashna Dhoonmoon Nathanial J. Tolman Anchal Sharma Xinwen Liang Yuka Imamura Kawasawa Claudia M. Nicolae Hong-Gang Wang Subhajyoti De George-Lucian Moldovan
author_facet	Kristen E. Clements Emily M. Schleicher Tanay Thakar Anastasia Hale Ashna Dhoonmoon Nathanial J. Tolman Anchal Sharma Xinwen Liang Yuka Imamura Kawasawa Claudia M. Nicolae Hong-Gang Wang Subhajyoti De George-Lucian Moldovan
author_sort	Kristen E. Clements
title	Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens
title_short	Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens
title_full	Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens
title_fullStr	Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens
title_full_unstemmed	Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens
title_sort	identification of regulators of poly-adp-ribose polymerase inhibitor response through complementary crispr knockout and activation screens
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bbee1b004cdc4bdebae2ddc9b6d5a3f3
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Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens

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