Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models

Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models

Abstract Therapeutic concepts exploiting tumor-specific antibodies are often established in pre-clinical xenograft models using immuno-deficient mice. More complex therapeutic paradigms, however, warrant the use of immuno-competent mice, that more accurately capture the relevant biology that is bein...

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Autores principales: Aran F. Labrijn, Joyce I. Meesters, Matthew Bunce, Anthony A. Armstrong, Sandeep Somani, Tom C. Nesspor, Mark L. Chiu, Işil Altintaş, Sandra Verploegen, Janine Schuurman, Paul W. H. I. Parren
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/bbef8d706f08451bb51dc1be0939cbc2
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