A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy

Many Amyotrophic Lateral Sclerosis (ALS)-linked mutations cause accumulation of stress granules, and most ALS cases are caused by repeat expansions in C9ORF72. Here the authors show that C9ORF72 and the autophagy receptor p62 interact to associate with proteins symmetrically dimethylated on arginine...

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Autores principales:	Maneka Chitiprolu, Chantal Jagow, Veronique Tremblay, Emma Bondy-Chorney, Geneviève Paris, Alexandre Savard, Gareth Palidwor, Francesca A. Barry, Lorne Zinman, Julia Keith, Ekaterina Rogaeva, Janice Robertson, Mathieu Lavallée-Adam, John Woulfe, Jean-François Couture, Jocelyn Côté, Derrick Gibbings
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bbf18a982cd84beb955aa489eecafe37
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spelling	oai:doaj.org-article:bbf18a982cd84beb955aa489eecafe372021-12-02T13:27:23ZA complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy10.1038/s41467-018-05273-72041-1723https://doaj.org/article/bbf18a982cd84beb955aa489eecafe372018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05273-7https://doaj.org/toc/2041-1723Many Amyotrophic Lateral Sclerosis (ALS)-linked mutations cause accumulation of stress granules, and most ALS cases are caused by repeat expansions in C9ORF72. Here the authors show that C9ORF72 and the autophagy receptor p62 interact to associate with proteins symmetrically dimethylated on arginines such as FUS, to eliminate stress granules by autophagy.Maneka ChitiproluChantal JagowVeronique TremblayEmma Bondy-ChorneyGeneviève ParisAlexandre SavardGareth PalidworFrancesca A. BarryLorne ZinmanJulia KeithEkaterina RogaevaJanice RobertsonMathieu Lavallée-AdamJohn WoulfeJean-François CoutureJocelyn CôtéDerrick GibbingsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maneka Chitiprolu Chantal Jagow Veronique Tremblay Emma Bondy-Chorney Geneviève Paris Alexandre Savard Gareth Palidwor Francesca A. Barry Lorne Zinman Julia Keith Ekaterina Rogaeva Janice Robertson Mathieu Lavallée-Adam John Woulfe Jean-François Couture Jocelyn Côté Derrick Gibbings A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy
description	Many Amyotrophic Lateral Sclerosis (ALS)-linked mutations cause accumulation of stress granules, and most ALS cases are caused by repeat expansions in C9ORF72. Here the authors show that C9ORF72 and the autophagy receptor p62 interact to associate with proteins symmetrically dimethylated on arginines such as FUS, to eliminate stress granules by autophagy.
format	article
author	Maneka Chitiprolu Chantal Jagow Veronique Tremblay Emma Bondy-Chorney Geneviève Paris Alexandre Savard Gareth Palidwor Francesca A. Barry Lorne Zinman Julia Keith Ekaterina Rogaeva Janice Robertson Mathieu Lavallée-Adam John Woulfe Jean-François Couture Jocelyn Côté Derrick Gibbings
author_facet	Maneka Chitiprolu Chantal Jagow Veronique Tremblay Emma Bondy-Chorney Geneviève Paris Alexandre Savard Gareth Palidwor Francesca A. Barry Lorne Zinman Julia Keith Ekaterina Rogaeva Janice Robertson Mathieu Lavallée-Adam John Woulfe Jean-François Couture Jocelyn Côté Derrick Gibbings
author_sort	Maneka Chitiprolu
title	A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy
title_short	A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy
title_full	A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy
title_fullStr	A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy
title_full_unstemmed	A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy
title_sort	complex of c9orf72 and p62 uses arginine methylation to eliminate stress granules by autophagy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/bbf18a982cd84beb955aa489eecafe37
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_version_	1718392998476120064

A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy

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