<i>CD46</i> Genetic Variability and HIV-1 Infection Susceptibility
<i>CD46</i> is the main receptor for complement protein C3 and plays an important role in adaptive immune responses. <i>CD46</i> genetic variants are associated with susceptibility to several infectious and autoimmune diseases. Additionally, <i>CD46</i> function c...
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| Autores principales: | , , , , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/bbf43ea316c04ec5acdaddec2916027b |
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| Sumario: | <i>CD46</i> is the main receptor for complement protein C3 and plays an important role in adaptive immune responses. <i>CD46</i> genetic variants are associated with susceptibility to several infectious and autoimmune diseases. Additionally, <i>CD46</i> function can be subverted by HIV-1 to evade attack by complement, a strategy shared by viruses of other families. We sought to determine the association between <i>CD46</i> gene variants and HIV-1 acquired through intravenous drug use (IDU) and sexual routes (<i>n</i> = 823). Study subjects were of European ancestry and were HIV-1 infected (<i>n</i> = 438) or exposed but seronegative (<i>n</i> = 387). Genotyping of the rs2796265 SNP located in the <i>CD46</i> gene region was done by allele-specific real-time PCR. A meta-analysis merging IDU and sexual cohorts indicates that the minor genotype (CC) was associated with increased resistance to HIV-1 infection OR = 0.2, 95% CI (0.07–0.61), <i>p</i> = 0.004. The HIV-1-protective genotype is correlated with reduced <i>CD46</i> expression and alterations in the ratio of <i>CD46</i> mRNA splicing isoforms. |
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