CD46 Genetic Variability and HIV-1 Infection Susceptibility

CD46 is the main receptor for complement protein C3 and plays an important role in adaptive immune responses. CD46 genetic variants are associated with susceptibility to several infectious and autoimmune diseases. Additionally, CD46 function c...

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Autores principales:	Carmen Serrano-Rísquez, Mohamed Omar, María Amparo Gómez-Vidal, Luis Miguel Real, Juan Antonio Pineda, Antonio Rivero, Antonio Rivero-Juárez, Donald Forthal, Francisco J. Márquez, Sergio Lo Caputo, Mario Clerici, Mara Biasin, Antonio Caruz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	HIV-1 HIV exposed seronegative HESN <i>CD46</i> complement Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bbf43ea316c04ec5acdaddec2916027b
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id	oai:doaj.org-article:bbf43ea316c04ec5acdaddec2916027b
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spelling	oai:doaj.org-article:bbf43ea316c04ec5acdaddec2916027b2021-11-25T17:11:26Z<i>CD46</i> Genetic Variability and HIV-1 Infection Susceptibility10.3390/cells101130942073-4409https://doaj.org/article/bbf43ea316c04ec5acdaddec2916027b2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3094https://doaj.org/toc/2073-4409<i>CD46</i> is the main receptor for complement protein C3 and plays an important role in adaptive immune responses. <i>CD46</i> genetic variants are associated with susceptibility to several infectious and autoimmune diseases. Additionally, <i>CD46</i> function can be subverted by HIV-1 to evade attack by complement, a strategy shared by viruses of other families. We sought to determine the association between <i>CD46</i> gene variants and HIV-1 acquired through intravenous drug use (IDU) and sexual routes (<i>n</i> = 823). Study subjects were of European ancestry and were HIV-1 infected (<i>n</i> = 438) or exposed but seronegative (<i>n</i> = 387). Genotyping of the rs2796265 SNP located in the <i>CD46</i> gene region was done by allele-specific real-time PCR. A meta-analysis merging IDU and sexual cohorts indicates that the minor genotype (CC) was associated with increased resistance to HIV-1 infection OR = 0.2, 95% CI (0.07–0.61), <i>p</i> = 0.004. The HIV-1-protective genotype is correlated with reduced <i>CD46</i> expression and alterations in the ratio of <i>CD46</i> mRNA splicing isoforms.Carmen Serrano-RísquezMohamed OmarMaría Amparo Gómez-VidalLuis Miguel RealJuan Antonio PinedaAntonio RiveroAntonio Rivero-JuárezDonald ForthalFrancisco J. MárquezSergio Lo CaputoMario ClericiMara BiasinAntonio CaruzMDPI AGarticleHIV-1HIV exposed seronegativeHESN<i>CD46</i>complementBiology (General)QH301-705.5ENCells, Vol 10, Iss 3094, p 3094 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HIV-1 HIV exposed seronegative HESN <i>CD46</i> complement Biology (General) QH301-705.5
spellingShingle	HIV-1 HIV exposed seronegative HESN <i>CD46</i> complement Biology (General) QH301-705.5 Carmen Serrano-Rísquez Mohamed Omar María Amparo Gómez-Vidal Luis Miguel Real Juan Antonio Pineda Antonio Rivero Antonio Rivero-Juárez Donald Forthal Francisco J. Márquez Sergio Lo Caputo Mario Clerici Mara Biasin Antonio Caruz <i>CD46</i> Genetic Variability and HIV-1 Infection Susceptibility
description	<i>CD46</i> is the main receptor for complement protein C3 and plays an important role in adaptive immune responses. <i>CD46</i> genetic variants are associated with susceptibility to several infectious and autoimmune diseases. Additionally, <i>CD46</i> function can be subverted by HIV-1 to evade attack by complement, a strategy shared by viruses of other families. We sought to determine the association between <i>CD46</i> gene variants and HIV-1 acquired through intravenous drug use (IDU) and sexual routes (<i>n</i> = 823). Study subjects were of European ancestry and were HIV-1 infected (<i>n</i> = 438) or exposed but seronegative (<i>n</i> = 387). Genotyping of the rs2796265 SNP located in the <i>CD46</i> gene region was done by allele-specific real-time PCR. A meta-analysis merging IDU and sexual cohorts indicates that the minor genotype (CC) was associated with increased resistance to HIV-1 infection OR = 0.2, 95% CI (0.07–0.61), <i>p</i> = 0.004. The HIV-1-protective genotype is correlated with reduced <i>CD46</i> expression and alterations in the ratio of <i>CD46</i> mRNA splicing isoforms.
format	article
author	Carmen Serrano-Rísquez Mohamed Omar María Amparo Gómez-Vidal Luis Miguel Real Juan Antonio Pineda Antonio Rivero Antonio Rivero-Juárez Donald Forthal Francisco J. Márquez Sergio Lo Caputo Mario Clerici Mara Biasin Antonio Caruz
author_facet	Carmen Serrano-Rísquez Mohamed Omar María Amparo Gómez-Vidal Luis Miguel Real Juan Antonio Pineda Antonio Rivero Antonio Rivero-Juárez Donald Forthal Francisco J. Márquez Sergio Lo Caputo Mario Clerici Mara Biasin Antonio Caruz
author_sort	Carmen Serrano-Rísquez
title	<i>CD46</i> Genetic Variability and HIV-1 Infection Susceptibility
title_short	<i>CD46</i> Genetic Variability and HIV-1 Infection Susceptibility
title_full	<i>CD46</i> Genetic Variability and HIV-1 Infection Susceptibility
title_fullStr	<i>CD46</i> Genetic Variability and HIV-1 Infection Susceptibility
title_full_unstemmed	<i>CD46</i> Genetic Variability and HIV-1 Infection Susceptibility
title_sort	<i>cd46</i> genetic variability and hiv-1 infection susceptibility
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bbf43ea316c04ec5acdaddec2916027b
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<i>CD46</i> Genetic Variability and HIV-1 Infection Susceptibility

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