In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines

The purpose of the present study was to investigate and compare the effects of two ruthenium complexes with trifluoperazine on acethylcholinesterase enzyme activity and lactate dehydrogenase levels in vivo under physiological conditions in rats blood. Complexes 1 and 2 showed positive effects on ace...

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Autores principales:	Krstić P. Milena, Borozan Z. Sunčica, Sovilj P. Sofija, Grgurić-Šipka R. Sanja, Oljarević M. Jelena
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	ruthenium complexes n-alkylphenothiazines acethylcholinesterase lactate dehydrogenase Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/bbf58c1c3ab7474487be9275786196ec
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spelling	oai:doaj.org-article:bbf58c1c3ab7474487be9275786196ec2021-11-17T21:27:51ZIn Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines1820-744810.1515/acve-2016-0043https://doaj.org/article/bbf58c1c3ab7474487be9275786196ec2016-12-01T00:00:00Zhttps://doi.org/10.1515/acve-2016-0043https://doaj.org/toc/1820-7448The purpose of the present study was to investigate and compare the effects of two ruthenium complexes with trifluoperazine on acethylcholinesterase enzyme activity and lactate dehydrogenase levels in vivo under physiological conditions in rats blood. Complexes 1 and 2 showed positive effects on acethylcholinesterase at all doses and did not disturb its normal activity. Total LDH activity was inhibited in the presence of both complexes, but Ru(II) complexes showed different effects on the activity of LDH isoenzymes. The activities of LDH1 and LDH2 isoenzymes were decreased in all applied doses of the complex 2, while the activity of LDH2 reduced using complex 1 in the same doses. Results of the present study suggest the neuro- and cardio protective potential of oral administration of complexes 1 and 2, as non-toxic compounds under physiological conditions. These protective effects are the result of their potent antioxidant activity.Krstić P. MilenaBorozan Z. SunčicaSovilj P. SofijaGrgurić-Šipka R. SanjaOljarević M. JelenaSciendoarticleruthenium complexesn-alkylphenothiazinesacethylcholinesteraselactate dehydrogenaseVeterinary medicineSF600-1100ENActa Veterinaria, Vol 66, Iss 4, Pp 497-508 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	ruthenium complexes n-alkylphenothiazines acethylcholinesterase lactate dehydrogenase Veterinary medicine SF600-1100
spellingShingle	ruthenium complexes n-alkylphenothiazines acethylcholinesterase lactate dehydrogenase Veterinary medicine SF600-1100 Krstić P. Milena Borozan Z. Sunčica Sovilj P. Sofija Grgurić-Šipka R. Sanja Oljarević M. Jelena In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines
description	The purpose of the present study was to investigate and compare the effects of two ruthenium complexes with trifluoperazine on acethylcholinesterase enzyme activity and lactate dehydrogenase levels in vivo under physiological conditions in rats blood. Complexes 1 and 2 showed positive effects on acethylcholinesterase at all doses and did not disturb its normal activity. Total LDH activity was inhibited in the presence of both complexes, but Ru(II) complexes showed different effects on the activity of LDH isoenzymes. The activities of LDH1 and LDH2 isoenzymes were decreased in all applied doses of the complex 2, while the activity of LDH2 reduced using complex 1 in the same doses. Results of the present study suggest the neuro- and cardio protective potential of oral administration of complexes 1 and 2, as non-toxic compounds under physiological conditions. These protective effects are the result of their potent antioxidant activity.
format	article
author	Krstić P. Milena Borozan Z. Sunčica Sovilj P. Sofija Grgurić-Šipka R. Sanja Oljarević M. Jelena
author_facet	Krstić P. Milena Borozan Z. Sunčica Sovilj P. Sofija Grgurić-Šipka R. Sanja Oljarević M. Jelena
author_sort	Krstić P. Milena
title	In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines
title_short	In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines
title_full	In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines
title_fullStr	In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines
title_full_unstemmed	In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines
title_sort	in vivo enzymes activities of some ru(ii) compounds with n-alkylphenothiazines
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/bbf58c1c3ab7474487be9275786196ec
work_keys_str_mv	AT krsticpmilena invivoenzymesactivitiesofsomeruiicompoundswithnalkylphenothiazines AT borozanzsuncica invivoenzymesactivitiesofsomeruiicompoundswithnalkylphenothiazines AT soviljpsofija invivoenzymesactivitiesofsomeruiicompoundswithnalkylphenothiazines AT grguricsipkarsanja invivoenzymesactivitiesofsomeruiicompoundswithnalkylphenothiazines AT oljarevicmjelena invivoenzymesactivitiesofsomeruiicompoundswithnalkylphenothiazines
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In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines

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