Long-Term Favorable Visual Outcomes in Patients with Large Submacular Hemorrhage

Prashanth G Iyer,1 H Logan Brooks Jr,2 Harry W Flynn Jr1 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; 2Southern Vitreoretinal Associates, Tallahassee, FL, USACorrespondence: Harry W Flynn JrSouthern Vitreoretinal Associates...

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Autores principales:	Iyer PG, Brooks HL Jr, Flynn HW Jr
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	choroidal neovascularization submacular hemorrhage anti-vegf retinal toxicity age-related macular degeneration presumed ocular histoplasmosis syndrome Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/bbf59e499a344575b3a7150f7dd40105
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spelling	oai:doaj.org-article:bbf59e499a344575b3a7150f7dd401052021-12-02T11:39:16ZLong-Term Favorable Visual Outcomes in Patients with Large Submacular Hemorrhage1177-5483https://doaj.org/article/bbf59e499a344575b3a7150f7dd401052021-03-01T00:00:00Zhttps://www.dovepress.com/long-term-favorable-visual-outcomes-in-patients-with-large-submacular--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Prashanth G Iyer,1 H Logan Brooks Jr,2 Harry W Flynn Jr1 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; 2Southern Vitreoretinal Associates, Tallahassee, FL, USACorrespondence: Harry W Flynn JrSouthern Vitreoretinal Associates, 900 NW 17th Street, Miami, FL, 33136, USATel +1 305 326-6148Fax +1 305 326-6417Email hflynn@med.miami.eduAbstract: Submacular hemorrhage (SMH) has been reported to be toxic to the retina based on animal studies. However, observational studies of patients with neovascular-related SMH and those treated with intravitreal anti-vascular growth factor (anti-VEGF) therapy have shown many favorable visual acuity outcomes. We report two cases of neovascular-related SMH with ten or more years of follow-up. The first case was an 83-year old female with a history of nonexudative age-related macular degeneration in both eyes presenting with sudden decrease in vision (20/400) in her right eye due to a large SMH, treated with anti-VEGF therapy. Over the next following months, there was resolution of the hemorrhage and return of good visual acuity. At 10-year follow-up, visual acuity was 20/30 in the right eye. The second case was a 49-year old female with a history of presumed ocular histoplasmosis syndrome (POHS), presenting with sudden vision loss (20/400) in her right eye due to large, thick SMH. With observation and intermittent anti-VEGF therapy, there was resolution of the hemorrhage. At 30-year follow-up, visual acuity was 20/20 in the right eye.Keywords: choroidal neovascularization, submacular hemorrhage, anti-VEGF, retinal toxicity, age-related macular degeneration, presumed ocular histoplasmosis syndromeIyer PGBrooks HL JrFlynn HW JrDove Medical Pressarticlechoroidal neovascularizationsubmacular hemorrhageanti-vegfretinal toxicityage-related macular degenerationpresumed ocular histoplasmosis syndromeOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 1189-1192 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	choroidal neovascularization submacular hemorrhage anti-vegf retinal toxicity age-related macular degeneration presumed ocular histoplasmosis syndrome Ophthalmology RE1-994
spellingShingle	choroidal neovascularization submacular hemorrhage anti-vegf retinal toxicity age-related macular degeneration presumed ocular histoplasmosis syndrome Ophthalmology RE1-994 Iyer PG Brooks HL Jr Flynn HW Jr Long-Term Favorable Visual Outcomes in Patients with Large Submacular Hemorrhage
description	Prashanth G Iyer,1 H Logan Brooks Jr,2 Harry W Flynn Jr1 1Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA; 2Southern Vitreoretinal Associates, Tallahassee, FL, USACorrespondence: Harry W Flynn JrSouthern Vitreoretinal Associates, 900 NW 17th Street, Miami, FL, 33136, USATel +1 305 326-6148Fax +1 305 326-6417Email hflynn@med.miami.eduAbstract: Submacular hemorrhage (SMH) has been reported to be toxic to the retina based on animal studies. However, observational studies of patients with neovascular-related SMH and those treated with intravitreal anti-vascular growth factor (anti-VEGF) therapy have shown many favorable visual acuity outcomes. We report two cases of neovascular-related SMH with ten or more years of follow-up. The first case was an 83-year old female with a history of nonexudative age-related macular degeneration in both eyes presenting with sudden decrease in vision (20/400) in her right eye due to a large SMH, treated with anti-VEGF therapy. Over the next following months, there was resolution of the hemorrhage and return of good visual acuity. At 10-year follow-up, visual acuity was 20/30 in the right eye. The second case was a 49-year old female with a history of presumed ocular histoplasmosis syndrome (POHS), presenting with sudden vision loss (20/400) in her right eye due to large, thick SMH. With observation and intermittent anti-VEGF therapy, there was resolution of the hemorrhage. At 30-year follow-up, visual acuity was 20/20 in the right eye.Keywords: choroidal neovascularization, submacular hemorrhage, anti-VEGF, retinal toxicity, age-related macular degeneration, presumed ocular histoplasmosis syndrome
format	article
author	Iyer PG Brooks HL Jr Flynn HW Jr
author_facet	Iyer PG Brooks HL Jr Flynn HW Jr
author_sort	Iyer PG
title	Long-Term Favorable Visual Outcomes in Patients with Large Submacular Hemorrhage
title_short	Long-Term Favorable Visual Outcomes in Patients with Large Submacular Hemorrhage
title_full	Long-Term Favorable Visual Outcomes in Patients with Large Submacular Hemorrhage
title_fullStr	Long-Term Favorable Visual Outcomes in Patients with Large Submacular Hemorrhage
title_full_unstemmed	Long-Term Favorable Visual Outcomes in Patients with Large Submacular Hemorrhage
title_sort	long-term favorable visual outcomes in patients with large submacular hemorrhage
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/bbf59e499a344575b3a7150f7dd40105
work_keys_str_mv	AT iyerpg longtermfavorablevisualoutcomesinpatientswithlargesubmacularhemorrhage AT brookshljr longtermfavorablevisualoutcomesinpatientswithlargesubmacularhemorrhage AT flynnhwjr longtermfavorablevisualoutcomesinpatientswithlargesubmacularhemorrhage
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Long-Term Favorable Visual Outcomes in Patients with Large Submacular Hemorrhage

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