Objective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in Parkinson's disease.

<h4>Introduction</h4>Sleep-wake disturbances and concomitant cognitive dysfunction in Parkinson's disease (PD) contribute significantly to morbidity in patients and their carers. Subjectively reported daytime sleep disturbance is observed in over half of all patients with PD and has...

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Autores principales:	Samuel J Bolitho, Sharon L Naismith, Pierre Salahuddin, Zoe Terpening, Ron R Grunstein, Simon J G Lewis
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bbf7945e0470477fad4103dd546f2f2b
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spelling	oai:doaj.org-article:bbf7945e0470477fad4103dd546f2f2b2021-11-18T08:45:10ZObjective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in Parkinson's disease.1932-620310.1371/journal.pone.0081233https://doaj.org/article/bbf7945e0470477fad4103dd546f2f2b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278399/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Sleep-wake disturbances and concomitant cognitive dysfunction in Parkinson's disease (PD) contribute significantly to morbidity in patients and their carers. Subjectively reported daytime sleep disturbance is observed in over half of all patients with PD and has been linked to executive cognitive dysfunction. The current study used daytime actigraphy, a novel objective measure of napping and related this to neuropsychological performance in a sample of PD patients and healthy, age and gender-matched controls. Furthermore this study aimed to identify patients with PD who may benefit from pharmacologic and behavioural intervention to improve these symptoms.<h4>Methods</h4>Eighty-five PD patients and 21 healthy, age-matched controls completed 14 days of wrist actigraphy within two weeks of neuropsychological testing. Objective napping measures were derived from actigraphy using a standardised protocol and subjective daytime sleepiness was recorded by the previously validated Epworth Sleepiness Scale.<h4>Results</h4>Patients with PD had a 225% increase in the mean nap time per day (minutes) as recorded by actigraphy compared to age matched controls (39.2 ± 35.2 vs. 11.5 ± 11.0 minutes respectively, p < 0.001). Significantly, differences in napping duration between patients, as recorded by actigraphy were not distinguished by their ratings on the subjective measurement of excessive daytime sleepiness. Finally, those patients with excessive daytime napping showed greater cognitive deficits in the domains of attention, semantic verbal fluency and processing speed.<h4>Conclusion</h4>This study confirms increased levels of napping in PD, a finding that is concordant with subjective reports. However, subjective self-report measures of excessive daytime sleepiness do not robustly identify excessive napping in PD. Fronto-subcortical cognitive dysfunction was observed in those patients who napped excessively. Furthermore, this study suggests that daytime actigraphy, a non-invasive and inexpensive objective measure of daytime sleep, can identify patients with PD who may benefit from pharmacologic and behavioural interventions to improve these symptoms.Samuel J BolithoSharon L NaismithPierre SalahuddinZoe TerpeningRon R GrunsteinSimon J G LewisPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e81233 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Samuel J Bolitho Sharon L Naismith Pierre Salahuddin Zoe Terpening Ron R Grunstein Simon J G Lewis Objective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in Parkinson's disease.
description	<h4>Introduction</h4>Sleep-wake disturbances and concomitant cognitive dysfunction in Parkinson's disease (PD) contribute significantly to morbidity in patients and their carers. Subjectively reported daytime sleep disturbance is observed in over half of all patients with PD and has been linked to executive cognitive dysfunction. The current study used daytime actigraphy, a novel objective measure of napping and related this to neuropsychological performance in a sample of PD patients and healthy, age and gender-matched controls. Furthermore this study aimed to identify patients with PD who may benefit from pharmacologic and behavioural intervention to improve these symptoms.<h4>Methods</h4>Eighty-five PD patients and 21 healthy, age-matched controls completed 14 days of wrist actigraphy within two weeks of neuropsychological testing. Objective napping measures were derived from actigraphy using a standardised protocol and subjective daytime sleepiness was recorded by the previously validated Epworth Sleepiness Scale.<h4>Results</h4>Patients with PD had a 225% increase in the mean nap time per day (minutes) as recorded by actigraphy compared to age matched controls (39.2 ± 35.2 vs. 11.5 ± 11.0 minutes respectively, p < 0.001). Significantly, differences in napping duration between patients, as recorded by actigraphy were not distinguished by their ratings on the subjective measurement of excessive daytime sleepiness. Finally, those patients with excessive daytime napping showed greater cognitive deficits in the domains of attention, semantic verbal fluency and processing speed.<h4>Conclusion</h4>This study confirms increased levels of napping in PD, a finding that is concordant with subjective reports. However, subjective self-report measures of excessive daytime sleepiness do not robustly identify excessive napping in PD. Fronto-subcortical cognitive dysfunction was observed in those patients who napped excessively. Furthermore, this study suggests that daytime actigraphy, a non-invasive and inexpensive objective measure of daytime sleep, can identify patients with PD who may benefit from pharmacologic and behavioural interventions to improve these symptoms.
format	article
author	Samuel J Bolitho Sharon L Naismith Pierre Salahuddin Zoe Terpening Ron R Grunstein Simon J G Lewis
author_facet	Samuel J Bolitho Sharon L Naismith Pierre Salahuddin Zoe Terpening Ron R Grunstein Simon J G Lewis
author_sort	Samuel J Bolitho
title	Objective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in Parkinson's disease.
title_short	Objective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in Parkinson's disease.
title_full	Objective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in Parkinson's disease.
title_fullStr	Objective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in Parkinson's disease.
title_full_unstemmed	Objective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in Parkinson's disease.
title_sort	objective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in parkinson's disease.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/bbf7945e0470477fad4103dd546f2f2b
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Objective measurement of daytime napping, cognitive dysfunction and subjective sleepiness in Parkinson's disease.

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