A Local Counter-Regulatory Motif Modulates the Global Phase of Hormonal Oscillations

Abstract Counter-regulatory elements maintain dynamic equilibrium ubiquitously in living systems. The most prominent example, which is critical to mammalian survival, is that of pancreatic α and β cells producing glucagon and insulin for glucose homeostasis. These cells are not found in a single gla...

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Autores principales:	Dong-Ho Park, Taegeun Song, Danh-Tai Hoang, Jin Xu, Junghyo Jo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bbfb8220185b4f5a87f9d951ad7670d7
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spelling	oai:doaj.org-article:bbfb8220185b4f5a87f9d951ad7670d72021-12-02T11:52:18ZA Local Counter-Regulatory Motif Modulates the Global Phase of Hormonal Oscillations10.1038/s41598-017-01806-02045-2322https://doaj.org/article/bbfb8220185b4f5a87f9d951ad7670d72017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01806-0https://doaj.org/toc/2045-2322Abstract Counter-regulatory elements maintain dynamic equilibrium ubiquitously in living systems. The most prominent example, which is critical to mammalian survival, is that of pancreatic α and β cells producing glucagon and insulin for glucose homeostasis. These cells are not found in a single gland but are dispersed in multiple micro-organs known as the islets of Langerhans. Within an islet, these two reciprocal cell types interact with each other and with an additional cell type: the δ cell. By testing all possible motifs governing the interactions of these three cell types, we found that a unique set of positive/negative intra-islet interactions between different islet cell types functions not only to reduce the superficially wasteful zero-sum action of glucagon and insulin but also to enhance/suppress the synchronization of hormone secretions between islets under high/normal glucose conditions. This anti-symmetric interaction motif confers effective controllability for network (de)synchronization.Dong-Ho ParkTaegeun SongDanh-Tai HoangJin XuJunghyo JoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dong-Ho Park Taegeun Song Danh-Tai Hoang Jin Xu Junghyo Jo A Local Counter-Regulatory Motif Modulates the Global Phase of Hormonal Oscillations
description	Abstract Counter-regulatory elements maintain dynamic equilibrium ubiquitously in living systems. The most prominent example, which is critical to mammalian survival, is that of pancreatic α and β cells producing glucagon and insulin for glucose homeostasis. These cells are not found in a single gland but are dispersed in multiple micro-organs known as the islets of Langerhans. Within an islet, these two reciprocal cell types interact with each other and with an additional cell type: the δ cell. By testing all possible motifs governing the interactions of these three cell types, we found that a unique set of positive/negative intra-islet interactions between different islet cell types functions not only to reduce the superficially wasteful zero-sum action of glucagon and insulin but also to enhance/suppress the synchronization of hormone secretions between islets under high/normal glucose conditions. This anti-symmetric interaction motif confers effective controllability for network (de)synchronization.
format	article
author	Dong-Ho Park Taegeun Song Danh-Tai Hoang Jin Xu Junghyo Jo
author_facet	Dong-Ho Park Taegeun Song Danh-Tai Hoang Jin Xu Junghyo Jo
author_sort	Dong-Ho Park
title	A Local Counter-Regulatory Motif Modulates the Global Phase of Hormonal Oscillations
title_short	A Local Counter-Regulatory Motif Modulates the Global Phase of Hormonal Oscillations
title_full	A Local Counter-Regulatory Motif Modulates the Global Phase of Hormonal Oscillations
title_fullStr	A Local Counter-Regulatory Motif Modulates the Global Phase of Hormonal Oscillations
title_full_unstemmed	A Local Counter-Regulatory Motif Modulates the Global Phase of Hormonal Oscillations
title_sort	local counter-regulatory motif modulates the global phase of hormonal oscillations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bbfb8220185b4f5a87f9d951ad7670d7
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A Local Counter-Regulatory Motif Modulates the Global Phase of Hormonal Oscillations

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