Clinical and prognostic association of transcription factor SOX4 in gastric cancer.

Gastric cancer (GC) is one of the most common malignant cancers worldwide. However, little is known about the molecular process by which this disease develops and progresses. This study investigated correlations between the expression of nuclear transcription factor SOX4 and various clinicopathologi...

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Autores principales:	Chia-Lang Fang, You-Cheng Hseu, Yi-Feng Lin, Shih-Ting Hung, Chein Tai, Yih-Huei Uen, Kai-Yuan Lin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bbfdf654ea464529b74bd004871d64a2
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spelling	oai:doaj.org-article:bbfdf654ea464529b74bd004871d64a22021-11-18T08:04:02ZClinical and prognostic association of transcription factor SOX4 in gastric cancer.1932-620310.1371/journal.pone.0052804https://doaj.org/article/bbfdf654ea464529b74bd004871d64a22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23285187/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Gastric cancer (GC) is one of the most common malignant cancers worldwide. However, little is known about the molecular process by which this disease develops and progresses. This study investigated correlations between the expression of nuclear transcription factor SOX4 and various clinicopathologic parameters as well as patients' survival. Expression levels of nuclear SOX4 were analyzed by immunohistochemistry; the data comprised gastric tissues from 168 patients with GC. Paired t tests were used to analyze the differences in nuclear SOX4 expression between tumor and non-tumor tissues from each patient. Two-tailed Χ(2) tests were performed to determine whether the differences in nuclear SOX4 expression and clinicopathologic parameters were significant. Time-to-event endpoints for clinicopathologic parameters were plotted using the Kaplan-Meier method, and statistical significance was determined using univariate log-rank tests. Cox proportional hazard model was used for multivariate analysis to determine the independence of prognostic effects of nuclear SOX4 expression. Overexpression of nuclear SOX4 was significantly correlated with depth of invasion (P<0.0001), nodal status (P=0.0055), distant metastasis (P=0.0195), stage (P=0.0003), and vascular invasion (P=0.0383). Patients who displayed high expression levels of nuclear SOX4 achieved a significantly poorer disease-free survival rate, compared with patients with low SOX4 expression levels (P=0.003). Univariate Cox regression analysis showed that overexpression of nuclear SOX4 was a clear prognostic marker for GC (P=0.004). Overexpression of nuclear SOX4 can be used as a marker to predict the outcome of patients with GC.Chia-Lang FangYou-Cheng HseuYi-Feng LinShih-Ting HungChein TaiYih-Huei UenKai-Yuan LinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52804 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chia-Lang Fang You-Cheng Hseu Yi-Feng Lin Shih-Ting Hung Chein Tai Yih-Huei Uen Kai-Yuan Lin Clinical and prognostic association of transcription factor SOX4 in gastric cancer.
description	Gastric cancer (GC) is one of the most common malignant cancers worldwide. However, little is known about the molecular process by which this disease develops and progresses. This study investigated correlations between the expression of nuclear transcription factor SOX4 and various clinicopathologic parameters as well as patients' survival. Expression levels of nuclear SOX4 were analyzed by immunohistochemistry; the data comprised gastric tissues from 168 patients with GC. Paired t tests were used to analyze the differences in nuclear SOX4 expression between tumor and non-tumor tissues from each patient. Two-tailed Χ(2) tests were performed to determine whether the differences in nuclear SOX4 expression and clinicopathologic parameters were significant. Time-to-event endpoints for clinicopathologic parameters were plotted using the Kaplan-Meier method, and statistical significance was determined using univariate log-rank tests. Cox proportional hazard model was used for multivariate analysis to determine the independence of prognostic effects of nuclear SOX4 expression. Overexpression of nuclear SOX4 was significantly correlated with depth of invasion (P<0.0001), nodal status (P=0.0055), distant metastasis (P=0.0195), stage (P=0.0003), and vascular invasion (P=0.0383). Patients who displayed high expression levels of nuclear SOX4 achieved a significantly poorer disease-free survival rate, compared with patients with low SOX4 expression levels (P=0.003). Univariate Cox regression analysis showed that overexpression of nuclear SOX4 was a clear prognostic marker for GC (P=0.004). Overexpression of nuclear SOX4 can be used as a marker to predict the outcome of patients with GC.
format	article
author	Chia-Lang Fang You-Cheng Hseu Yi-Feng Lin Shih-Ting Hung Chein Tai Yih-Huei Uen Kai-Yuan Lin
author_facet	Chia-Lang Fang You-Cheng Hseu Yi-Feng Lin Shih-Ting Hung Chein Tai Yih-Huei Uen Kai-Yuan Lin
author_sort	Chia-Lang Fang
title	Clinical and prognostic association of transcription factor SOX4 in gastric cancer.
title_short	Clinical and prognostic association of transcription factor SOX4 in gastric cancer.
title_full	Clinical and prognostic association of transcription factor SOX4 in gastric cancer.
title_fullStr	Clinical and prognostic association of transcription factor SOX4 in gastric cancer.
title_full_unstemmed	Clinical and prognostic association of transcription factor SOX4 in gastric cancer.
title_sort	clinical and prognostic association of transcription factor sox4 in gastric cancer.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/bbfdf654ea464529b74bd004871d64a2
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Clinical and prognostic association of transcription factor SOX4 in gastric cancer.

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