DETECTION OF AUTO- AND ALLOANTIBODIES AGAINST GRANULOCYTES BY MEANS OF GEL AGGLUTINATION TECHNIQUE

Аbstract. Granulocyte antigen-specific autoantibodies may be implicated into pathogenesis of autoand alloimmune neutropenia, neonatal alloimmune neutropenia, and acute pulmonary insufficiency occurring post-transfusion. However, detection and identification of clinically significant...

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Autores principales:	N. V. Mineeva, E. V. Elkhina, N. N. Bodrova, O. A. Zavarzina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	neutropenia granulocytes antigens antibodies immunoglobulin Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/bc012de3aa494044ba095d76ac598dd8
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spelling	oai:doaj.org-article:bc012de3aa494044ba095d76ac598dd82021-11-18T08:03:41ZDETECTION OF AUTO- AND ALLOANTIBODIES AGAINST GRANULOCYTES BY MEANS OF GEL AGGLUTINATION TECHNIQUE1563-06252313-741X10.15789/1563-0625-2011-2-3-253-256https://doaj.org/article/bc012de3aa494044ba095d76ac598dd82014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/507https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XАbstract. Granulocyte antigen-specific autoantibodies may be implicated into pathogenesis of autoand alloimmune neutropenia, neonatal alloimmune neutropenia, and acute pulmonary insufficiency occurring post-transfusion. However, detection and identification of clinically significant granulocyte antibodies still represent a technically difficult task. To detect immunoglobulins and/or activated complement on granulocyte surface, we have adapted a Gel Test (ID Micro Typing System, DiaMed, Switzerland) which is commonly applied for diagnostics of RBC-specific antibodies. Our results suggest that the data from this gel test are quite reproducible, and the system may be used for detection of granulocyte-specific antibodies belonging to different immunoglobulin classes. (Med. Immunol., 2011, vol. 13, N 2-3, pp 253-256)N. V. MineevaE. V. ElkhinaN. N. BodrovaO. A. ZavarzinaSPb RAACIarticleneutropeniagranulocytesantigensantibodiesimmunoglobulinImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 253-256 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	neutropenia granulocytes antigens antibodies immunoglobulin Immunologic diseases. Allergy RC581-607
spellingShingle	neutropenia granulocytes antigens antibodies immunoglobulin Immunologic diseases. Allergy RC581-607 N. V. Mineeva E. V. Elkhina N. N. Bodrova O. A. Zavarzina DETECTION OF AUTO- AND ALLOANTIBODIES AGAINST GRANULOCYTES BY MEANS OF GEL AGGLUTINATION TECHNIQUE
description	Аbstract. Granulocyte antigen-specific autoantibodies may be implicated into pathogenesis of autoand alloimmune neutropenia, neonatal alloimmune neutropenia, and acute pulmonary insufficiency occurring post-transfusion. However, detection and identification of clinically significant granulocyte antibodies still represent a technically difficult task. To detect immunoglobulins and/or activated complement on granulocyte surface, we have adapted a Gel Test (ID Micro Typing System, DiaMed, Switzerland) which is commonly applied for diagnostics of RBC-specific antibodies. Our results suggest that the data from this gel test are quite reproducible, and the system may be used for detection of granulocyte-specific antibodies belonging to different immunoglobulin classes. (Med. Immunol., 2011, vol. 13, N 2-3, pp 253-256)
format	article
author	N. V. Mineeva E. V. Elkhina N. N. Bodrova O. A. Zavarzina
author_facet	N. V. Mineeva E. V. Elkhina N. N. Bodrova O. A. Zavarzina
author_sort	N. V. Mineeva
title	DETECTION OF AUTO- AND ALLOANTIBODIES AGAINST GRANULOCYTES BY MEANS OF GEL AGGLUTINATION TECHNIQUE
title_short	DETECTION OF AUTO- AND ALLOANTIBODIES AGAINST GRANULOCYTES BY MEANS OF GEL AGGLUTINATION TECHNIQUE
title_full	DETECTION OF AUTO- AND ALLOANTIBODIES AGAINST GRANULOCYTES BY MEANS OF GEL AGGLUTINATION TECHNIQUE
title_fullStr	DETECTION OF AUTO- AND ALLOANTIBODIES AGAINST GRANULOCYTES BY MEANS OF GEL AGGLUTINATION TECHNIQUE
title_full_unstemmed	DETECTION OF AUTO- AND ALLOANTIBODIES AGAINST GRANULOCYTES BY MEANS OF GEL AGGLUTINATION TECHNIQUE
title_sort	detection of auto- and alloantibodies against granulocytes by means of gel agglutination technique
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/bc012de3aa494044ba095d76ac598dd8
work_keys_str_mv	AT nvmineeva detectionofautoandalloantibodiesagainstgranulocytesbymeansofgelagglutinationtechnique AT evelkhina detectionofautoandalloantibodiesagainstgranulocytesbymeansofgelagglutinationtechnique AT nnbodrova detectionofautoandalloantibodiesagainstgranulocytesbymeansofgelagglutinationtechnique AT oazavarzina detectionofautoandalloantibodiesagainstgranulocytesbymeansofgelagglutinationtechnique
_version_	1718422503785758720

DETECTION OF AUTO- AND ALLOANTIBODIES AGAINST GRANULOCYTES BY MEANS OF GEL AGGLUTINATION TECHNIQUE

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