Incidence, demographics, and survival of patients with primary pituitary tumors: a SEER database study in 2004–2016

Abstract Comprehensive investigations on the incidence and prognosis of pituitary tumors are still lacking. The present study aims to summarize the incidence, demographics, and survival outcome of pituitary adenoma on a population-based level. This study includes all pituitary adenomas reported in t...

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Autores principales:	Cheng Chen, Yu Hu, Liang Lyu, Senlin Yin, Yang Yu, Shu Jiang, Peizhi Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bc0377796ddb49f482aabe76309a2bcc
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spelling	oai:doaj.org-article:bc0377796ddb49f482aabe76309a2bcc2021-12-02T16:24:56ZIncidence, demographics, and survival of patients with primary pituitary tumors: a SEER database study in 2004–201610.1038/s41598-021-94658-82045-2322https://doaj.org/article/bc0377796ddb49f482aabe76309a2bcc2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94658-8https://doaj.org/toc/2045-2322Abstract Comprehensive investigations on the incidence and prognosis of pituitary tumors are still lacking. The present study aims to summarize the incidence, demographics, and survival outcome of pituitary adenoma on a population-based level. This study includes all pituitary adenomas reported in the Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2016 in the United States. Extensive clinical and demographic characteristics were extracted and submitted to group comparisons. The standardized incidence rate was calculated and stratified by year at diagnosis, age/sex and age/treatment groups. The Kaplan–Meier analysis and multivariable regressions were performed to identify the factors associated with overall survival. A total of 47,180 pituitary tumors were identified, including 47,030 typical adenomas, 111 uncertain behavior pituitary adenomas, and 39 pituitary carcinomas. The overall standardized incidence rate was 4.8 cases per 100,000 person-years and the annual incidence rate continually trended upwards, with a peak seen in 2015. We noticed a bimodal age-related distribution in females and a unimodal distribution in males. In the multivariate regression analysis, the factors associated with prolonged survival included typical adenoma, younger age, and smaller tumor size. Whereas, black and male patients had worse overall survival. Our study provides a reliable estimate on the incidence of pituitary adenoma and confirms that the annual standardized incidence rate is increasing. Pituitary adenomas have a satisfactory long-term prognosis and age, tumor size, and tumor subtypes are related to overall survival. Though statistically significant, our inferential findings should be constrained within the limitations of SEER database.Cheng ChenYu HuLiang LyuSenlin YinYang YuShu JiangPeizhi ZhouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cheng Chen Yu Hu Liang Lyu Senlin Yin Yang Yu Shu Jiang Peizhi Zhou Incidence, demographics, and survival of patients with primary pituitary tumors: a SEER database study in 2004–2016
description	Abstract Comprehensive investigations on the incidence and prognosis of pituitary tumors are still lacking. The present study aims to summarize the incidence, demographics, and survival outcome of pituitary adenoma on a population-based level. This study includes all pituitary adenomas reported in the Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2016 in the United States. Extensive clinical and demographic characteristics were extracted and submitted to group comparisons. The standardized incidence rate was calculated and stratified by year at diagnosis, age/sex and age/treatment groups. The Kaplan–Meier analysis and multivariable regressions were performed to identify the factors associated with overall survival. A total of 47,180 pituitary tumors were identified, including 47,030 typical adenomas, 111 uncertain behavior pituitary adenomas, and 39 pituitary carcinomas. The overall standardized incidence rate was 4.8 cases per 100,000 person-years and the annual incidence rate continually trended upwards, with a peak seen in 2015. We noticed a bimodal age-related distribution in females and a unimodal distribution in males. In the multivariate regression analysis, the factors associated with prolonged survival included typical adenoma, younger age, and smaller tumor size. Whereas, black and male patients had worse overall survival. Our study provides a reliable estimate on the incidence of pituitary adenoma and confirms that the annual standardized incidence rate is increasing. Pituitary adenomas have a satisfactory long-term prognosis and age, tumor size, and tumor subtypes are related to overall survival. Though statistically significant, our inferential findings should be constrained within the limitations of SEER database.
format	article
author	Cheng Chen Yu Hu Liang Lyu Senlin Yin Yang Yu Shu Jiang Peizhi Zhou
author_facet	Cheng Chen Yu Hu Liang Lyu Senlin Yin Yang Yu Shu Jiang Peizhi Zhou
author_sort	Cheng Chen
title	Incidence, demographics, and survival of patients with primary pituitary tumors: a SEER database study in 2004–2016
title_short	Incidence, demographics, and survival of patients with primary pituitary tumors: a SEER database study in 2004–2016
title_full	Incidence, demographics, and survival of patients with primary pituitary tumors: a SEER database study in 2004–2016
title_fullStr	Incidence, demographics, and survival of patients with primary pituitary tumors: a SEER database study in 2004–2016
title_full_unstemmed	Incidence, demographics, and survival of patients with primary pituitary tumors: a SEER database study in 2004–2016
title_sort	incidence, demographics, and survival of patients with primary pituitary tumors: a seer database study in 2004–2016
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bc0377796ddb49f482aabe76309a2bcc
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Incidence, demographics, and survival of patients with primary pituitary tumors: a SEER database study in 2004–2016

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