Effects of postmastectomy radiotherapy on survival in different age groups for patients with T3N0M0 breast cancer

Background: Postmastectomy radiotherapy (PMRT), as an important regional treatment, improves the survival rate of patients with T3N0M0 breast cancers. However, the therapeutic effect of PMRT on T3N0M0 patients in different age groups is unclear. Methods: Using Surveillance, Epidemiology, and End Res...

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Autores principales:	Meng-Ting He, Xun-Xi Lu, Zong-Chao Gou
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Postmastectomy radiotherapy T3N0M0 breast Cancer Overall survival Breast cancer-specific survival Age Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/bc03db731e134fd0961b2f4559a243b7
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spelling	oai:doaj.org-article:bc03db731e134fd0961b2f4559a243b72021-11-20T04:55:53ZEffects of postmastectomy radiotherapy on survival in different age groups for patients with T3N0M0 breast cancer1532-308010.1016/j.breast.2021.11.006https://doaj.org/article/bc03db731e134fd0961b2f4559a243b72021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0960977621009887https://doaj.org/toc/1532-3080Background: Postmastectomy radiotherapy (PMRT), as an important regional treatment, improves the survival rate of patients with T3N0M0 breast cancers. However, the therapeutic effect of PMRT on T3N0M0 patients in different age groups is unclear. Methods: Using Surveillance, Epidemiology, and End Results database, we identified 4840 T3N0M0 patients between 2000 and 2015. The primary and secondary outcomes were overall survival (OS) and breast cancer-specific survival (BCSS). Survival outcomes were compared using Kaplan-Meier survival test, COX regression analysis, propensity score matching and forest plot, which present the relationship between age and PMRT. Results: Survival analysis demonstrated that for young patients (aged 18–45 and 46–55), there was no significant difference in OS between with and without PMRT. However, for patients older than 65 years, PMRT could significantly improve survival time (P < 0.001). Multivariate Cox analysis of OS showed older patients with PMRT had a lower hazard ratio (HR) than those without PMRT (aged 56–65: HR = 0.67, P = 0.014; aged >65: HR = 0.60, P < 0.001), and little benefit for young patients. The consistent results were also observed in 1:1 matched cohort. Subgroup analysis revealed the survival HRs of with versus without PMRT for patients older than 65 years were significant in most subgroups. Conclusion: The effect of PMRT in T3N0M0 patients is related to the age. PMRT is associated with improved survival in older patients with T3N0M0 breast cancer, especially those older than 65 years. While the benefit of PMRT is limited in T3N0M0 patients of young age. The observation suggests the importance of age for T3N0M0 patients when individualized treatment is made.Meng-Ting HeXun-Xi LuZong-Chao GouElsevierarticlePostmastectomy radiotherapyT3N0M0 breast CancerOverall survivalBreast cancer-specific survivalAgeNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast, Vol 60, Iss , Pp 247-254 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Postmastectomy radiotherapy T3N0M0 breast Cancer Overall survival Breast cancer-specific survival Age Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Postmastectomy radiotherapy T3N0M0 breast Cancer Overall survival Breast cancer-specific survival Age Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Meng-Ting He Xun-Xi Lu Zong-Chao Gou Effects of postmastectomy radiotherapy on survival in different age groups for patients with T3N0M0 breast cancer
description	Background: Postmastectomy radiotherapy (PMRT), as an important regional treatment, improves the survival rate of patients with T3N0M0 breast cancers. However, the therapeutic effect of PMRT on T3N0M0 patients in different age groups is unclear. Methods: Using Surveillance, Epidemiology, and End Results database, we identified 4840 T3N0M0 patients between 2000 and 2015. The primary and secondary outcomes were overall survival (OS) and breast cancer-specific survival (BCSS). Survival outcomes were compared using Kaplan-Meier survival test, COX regression analysis, propensity score matching and forest plot, which present the relationship between age and PMRT. Results: Survival analysis demonstrated that for young patients (aged 18–45 and 46–55), there was no significant difference in OS between with and without PMRT. However, for patients older than 65 years, PMRT could significantly improve survival time (P < 0.001). Multivariate Cox analysis of OS showed older patients with PMRT had a lower hazard ratio (HR) than those without PMRT (aged 56–65: HR = 0.67, P = 0.014; aged >65: HR = 0.60, P < 0.001), and little benefit for young patients. The consistent results were also observed in 1:1 matched cohort. Subgroup analysis revealed the survival HRs of with versus without PMRT for patients older than 65 years were significant in most subgroups. Conclusion: The effect of PMRT in T3N0M0 patients is related to the age. PMRT is associated with improved survival in older patients with T3N0M0 breast cancer, especially those older than 65 years. While the benefit of PMRT is limited in T3N0M0 patients of young age. The observation suggests the importance of age for T3N0M0 patients when individualized treatment is made.
format	article
author	Meng-Ting He Xun-Xi Lu Zong-Chao Gou
author_facet	Meng-Ting He Xun-Xi Lu Zong-Chao Gou
author_sort	Meng-Ting He
title	Effects of postmastectomy radiotherapy on survival in different age groups for patients with T3N0M0 breast cancer
title_short	Effects of postmastectomy radiotherapy on survival in different age groups for patients with T3N0M0 breast cancer
title_full	Effects of postmastectomy radiotherapy on survival in different age groups for patients with T3N0M0 breast cancer
title_fullStr	Effects of postmastectomy radiotherapy on survival in different age groups for patients with T3N0M0 breast cancer
title_full_unstemmed	Effects of postmastectomy radiotherapy on survival in different age groups for patients with T3N0M0 breast cancer
title_sort	effects of postmastectomy radiotherapy on survival in different age groups for patients with t3n0m0 breast cancer
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/bc03db731e134fd0961b2f4559a243b7
work_keys_str_mv	AT mengtinghe effectsofpostmastectomyradiotherapyonsurvivalindifferentagegroupsforpatientswitht3n0m0breastcancer AT xunxilu effectsofpostmastectomyradiotherapyonsurvivalindifferentagegroupsforpatientswitht3n0m0breastcancer AT zongchaogou effectsofpostmastectomyradiotherapyonsurvivalindifferentagegroupsforpatientswitht3n0m0breastcancer
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Effects of postmastectomy radiotherapy on survival in different age groups for patients with T3N0M0 breast cancer

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