Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer

Abstract Hedgehog (Hh) pathway is involved in epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC) maintenance resulting in tumor progression. GDC-0449, an inhibitor of Hh pathway component smoothened (Smo) has shown promise in the treatment of various cancers including pancreatic canc...

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Autores principales: Vinod Kumar, Amit Kumar Chaudhary, Yuxiang Dong, Haizhen A. Zhong, Goutam Mondal, Feng Lin, Virender Kumar, Ram I. Mahato
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/bc04897ea06a4b9b92226e9887c43bf1
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