Influence of the H1N1 influenza pandemic on the humoral immune response to seasonal flu vaccines.

In this study, we hypothesized that the humoral response to trivalent seasonal influenza virus vaccines was influenced by rapid antigenic switching of H1 HA. We tested archived sera and peripheral blood mononuclear cells (PBMC) collected at prior to vaccination at day 0, as well as days 30 and 90 af...

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Autores principales:	Hyesun Jang, Ted M Ross
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bc073ef3a9474c46af64f7ee6f3ce0d5
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spelling	oai:doaj.org-article:bc073ef3a9474c46af64f7ee6f3ce0d52021-12-02T20:16:36ZInfluence of the H1N1 influenza pandemic on the humoral immune response to seasonal flu vaccines.1932-620310.1371/journal.pone.0258453https://doaj.org/article/bc073ef3a9474c46af64f7ee6f3ce0d52021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258453https://doaj.org/toc/1932-6203In this study, we hypothesized that the humoral response to trivalent seasonal influenza virus vaccines was influenced by rapid antigenic switching of H1 HA. We tested archived sera and peripheral blood mononuclear cells (PBMC) collected at prior to vaccination at day 0, as well as days 30 and 90 after vaccination during the 2009/2010 and 2010/2011 influenza virus seasons. During the 2009/2010 season, vaccination successfully induced antibodies with hemagglutinin inhibition (HAI) activity against both H1N1 and H3N2 vaccine components. For the 2010/2011 season, the A/California/04/2009 (CA/09) H1N1 elicited seroconversion (HAI titer = 1:40) and novel memory B cell (Bmem) responses from most individuals. However, the H3N2 influenza virus component of the vaccine, A/Perth/16/2009 (Perth/09), back-boosted and elicited antibodies with HAI activity and Bmem response to historical H3N2 influenza virus strains. Following stratification of the pre-existing antibody with HAI against the CA/09 H1N1, there was a negative correlation with HAI seroconversion to other vaccine strains. Overall, strong immune responses against CA/09 H1N1 influenza virus negatively influenced the induction of novel humoral responses.Hyesun JangTed M RossPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258453 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyesun Jang Ted M Ross Influence of the H1N1 influenza pandemic on the humoral immune response to seasonal flu vaccines.
description	In this study, we hypothesized that the humoral response to trivalent seasonal influenza virus vaccines was influenced by rapid antigenic switching of H1 HA. We tested archived sera and peripheral blood mononuclear cells (PBMC) collected at prior to vaccination at day 0, as well as days 30 and 90 after vaccination during the 2009/2010 and 2010/2011 influenza virus seasons. During the 2009/2010 season, vaccination successfully induced antibodies with hemagglutinin inhibition (HAI) activity against both H1N1 and H3N2 vaccine components. For the 2010/2011 season, the A/California/04/2009 (CA/09) H1N1 elicited seroconversion (HAI titer = 1:40) and novel memory B cell (Bmem) responses from most individuals. However, the H3N2 influenza virus component of the vaccine, A/Perth/16/2009 (Perth/09), back-boosted and elicited antibodies with HAI activity and Bmem response to historical H3N2 influenza virus strains. Following stratification of the pre-existing antibody with HAI against the CA/09 H1N1, there was a negative correlation with HAI seroconversion to other vaccine strains. Overall, strong immune responses against CA/09 H1N1 influenza virus negatively influenced the induction of novel humoral responses.
format	article
author	Hyesun Jang Ted M Ross
author_facet	Hyesun Jang Ted M Ross
author_sort	Hyesun Jang
title	Influence of the H1N1 influenza pandemic on the humoral immune response to seasonal flu vaccines.
title_short	Influence of the H1N1 influenza pandemic on the humoral immune response to seasonal flu vaccines.
title_full	Influence of the H1N1 influenza pandemic on the humoral immune response to seasonal flu vaccines.
title_fullStr	Influence of the H1N1 influenza pandemic on the humoral immune response to seasonal flu vaccines.
title_full_unstemmed	Influence of the H1N1 influenza pandemic on the humoral immune response to seasonal flu vaccines.
title_sort	influence of the h1n1 influenza pandemic on the humoral immune response to seasonal flu vaccines.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/bc073ef3a9474c46af64f7ee6f3ce0d5
work_keys_str_mv	AT hyesunjang influenceoftheh1n1influenzapandemiconthehumoralimmuneresponsetoseasonalfluvaccines AT tedmross influenceoftheh1n1influenzapandemiconthehumoralimmuneresponsetoseasonalfluvaccines
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Influence of the H1N1 influenza pandemic on the humoral immune response to seasonal flu vaccines.

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