Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes

Genome-wide association studies have uncovered several loci associated with diabetes risk. Here, the authors reanalyse public type 2 diabetes GWAS data to fine map 50 known loci and identify seven new ones, including one near ATGR2 on the X-chromosome that doubles the risk of diabetes in men.

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Autores principales: Sílvia Bonàs-Guarch, Marta Guindo-Martínez, Irene Miguel-Escalada, Niels Grarup, David Sebastian, Elias Rodriguez-Fos, Friman Sánchez, Mercè Planas-Fèlix, Paula Cortes-Sánchez, Santi González, Pascal Timshel, Tune H. Pers, Claire C. Morgan, Ignasi Moran, Goutham Atla, Juan R. González, Montserrat Puiggros, Jonathan Martí, Ehm A. Andersson, Carlos Díaz, Rosa M. Badia, Miriam Udler, Aaron Leong, Varindepal Kaur, Jason Flannick, Torben Jørgensen, Allan Linneberg, Marit E. Jørgensen, Daniel R. Witte, Cramer Christensen, Ivan Brandslund, Emil V. Appel, Robert A. Scott, Jian’an Luan, Claudia Langenberg, Nicholas J. Wareham, Oluf Pedersen, Antonio Zorzano, Jose C Florez, Torben Hansen, Jorge Ferrer, Josep Maria Mercader, David Torrents
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/bc0e732fc3984663bcd763ffc1af847e
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spelling oai:doaj.org-article:bc0e732fc3984663bcd763ffc1af847e2021-12-02T17:31:44ZRe-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes10.1038/s41467-017-02380-92041-1723https://doaj.org/article/bc0e732fc3984663bcd763ffc1af847e2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02380-9https://doaj.org/toc/2041-1723Genome-wide association studies have uncovered several loci associated with diabetes risk. Here, the authors reanalyse public type 2 diabetes GWAS data to fine map 50 known loci and identify seven new ones, including one near ATGR2 on the X-chromosome that doubles the risk of diabetes in men.Sílvia Bonàs-GuarchMarta Guindo-MartínezIrene Miguel-EscaladaNiels GrarupDavid SebastianElias Rodriguez-FosFriman SánchezMercè Planas-FèlixPaula Cortes-SánchezSanti GonzálezPascal TimshelTune H. PersClaire C. MorganIgnasi MoranGoutham AtlaJuan R. GonzálezMontserrat PuiggrosJonathan MartíEhm A. AnderssonCarlos DíazRosa M. BadiaMiriam UdlerAaron LeongVarindepal KaurJason FlannickTorben JørgensenAllan LinnebergMarit E. JørgensenDaniel R. WitteCramer ChristensenIvan BrandslundEmil V. AppelRobert A. ScottJian’an LuanClaudia LangenbergNicholas J. WarehamOluf PedersenAntonio ZorzanoJose C FlorezTorben HansenJorge FerrerJosep Maria MercaderDavid TorrentsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sílvia Bonàs-Guarch
Marta Guindo-Martínez
Irene Miguel-Escalada
Niels Grarup
David Sebastian
Elias Rodriguez-Fos
Friman Sánchez
Mercè Planas-Fèlix
Paula Cortes-Sánchez
Santi González
Pascal Timshel
Tune H. Pers
Claire C. Morgan
Ignasi Moran
Goutham Atla
Juan R. González
Montserrat Puiggros
Jonathan Martí
Ehm A. Andersson
Carlos Díaz
Rosa M. Badia
Miriam Udler
Aaron Leong
Varindepal Kaur
Jason Flannick
Torben Jørgensen
Allan Linneberg
Marit E. Jørgensen
Daniel R. Witte
Cramer Christensen
Ivan Brandslund
Emil V. Appel
Robert A. Scott
Jian’an Luan
Claudia Langenberg
Nicholas J. Wareham
Oluf Pedersen
Antonio Zorzano
Jose C Florez
Torben Hansen
Jorge Ferrer
Josep Maria Mercader
David Torrents
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
description Genome-wide association studies have uncovered several loci associated with diabetes risk. Here, the authors reanalyse public type 2 diabetes GWAS data to fine map 50 known loci and identify seven new ones, including one near ATGR2 on the X-chromosome that doubles the risk of diabetes in men.
format article
author Sílvia Bonàs-Guarch
Marta Guindo-Martínez
Irene Miguel-Escalada
Niels Grarup
David Sebastian
Elias Rodriguez-Fos
Friman Sánchez
Mercè Planas-Fèlix
Paula Cortes-Sánchez
Santi González
Pascal Timshel
Tune H. Pers
Claire C. Morgan
Ignasi Moran
Goutham Atla
Juan R. González
Montserrat Puiggros
Jonathan Martí
Ehm A. Andersson
Carlos Díaz
Rosa M. Badia
Miriam Udler
Aaron Leong
Varindepal Kaur
Jason Flannick
Torben Jørgensen
Allan Linneberg
Marit E. Jørgensen
Daniel R. Witte
Cramer Christensen
Ivan Brandslund
Emil V. Appel
Robert A. Scott
Jian’an Luan
Claudia Langenberg
Nicholas J. Wareham
Oluf Pedersen
Antonio Zorzano
Jose C Florez
Torben Hansen
Jorge Ferrer
Josep Maria Mercader
David Torrents
author_facet Sílvia Bonàs-Guarch
Marta Guindo-Martínez
Irene Miguel-Escalada
Niels Grarup
David Sebastian
Elias Rodriguez-Fos
Friman Sánchez
Mercè Planas-Fèlix
Paula Cortes-Sánchez
Santi González
Pascal Timshel
Tune H. Pers
Claire C. Morgan
Ignasi Moran
Goutham Atla
Juan R. González
Montserrat Puiggros
Jonathan Martí
Ehm A. Andersson
Carlos Díaz
Rosa M. Badia
Miriam Udler
Aaron Leong
Varindepal Kaur
Jason Flannick
Torben Jørgensen
Allan Linneberg
Marit E. Jørgensen
Daniel R. Witte
Cramer Christensen
Ivan Brandslund
Emil V. Appel
Robert A. Scott
Jian’an Luan
Claudia Langenberg
Nicholas J. Wareham
Oluf Pedersen
Antonio Zorzano
Jose C Florez
Torben Hansen
Jorge Ferrer
Josep Maria Mercader
David Torrents
author_sort Sílvia Bonàs-Guarch
title Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
title_short Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
title_full Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
title_fullStr Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
title_full_unstemmed Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
title_sort re-analysis of public genetic data reveals a rare x-chromosomal variant associated with type 2 diabetes
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/bc0e732fc3984663bcd763ffc1af847e
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