Altered attentional control over the salience network in complex regional pain syndrome
Abstract The degree and salience of pain have been known to be constantly monitored and modulated by the brain. In the case of maladaptive neural responses as reported in centralized pain conditions such as complex regional pain syndrome (CRPS), the perception of pain is amplified and remains elevat...
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Nature Portfolio
2018
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oai:doaj.org-article:bc114e7a0d57410487de761eb5e640ce2021-12-02T12:32:22ZAltered attentional control over the salience network in complex regional pain syndrome10.1038/s41598-018-25757-22045-2322https://doaj.org/article/bc114e7a0d57410487de761eb5e640ce2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25757-2https://doaj.org/toc/2045-2322Abstract The degree and salience of pain have been known to be constantly monitored and modulated by the brain. In the case of maladaptive neural responses as reported in centralized pain conditions such as complex regional pain syndrome (CRPS), the perception of pain is amplified and remains elevated even without sustained peripheral pain inputs. Given that the attentional state of the brain greatly influences the perception and interpretation of pain, we investigated the role of the attention network and its dynamic interactions with other pain-related networks of the brain in CRPS. We examined alterations in the intra- and inter-network functional connectivities in 21 individuals with CRPS and 49 controls. CRPS-related reduction in intra-network functional connectivity was found in the attention network. Individuals with CRPS had greater inter-network connectivities between the attention and salience networks as compared with healthy controls. Furthermore, individuals within the CRPS group with high levels of pain catastrophizing showed greater inter-network connectivities between the attention and salience networks. Taken together, the current findings suggest that these altered connectivities may be potentially associated with the maladaptive pain coping as found in CRPS patients.Jungyoon KimIlhyang KangYong-An ChungTae-Suk KimEun NamgungSuji LeeJin Kyoung OhHyeonseok S. JeongHanbyul ChoMyeong Ju KimTammy D. KimSoo Hyun ChoiSoo Mee LimIn Kyoon LyooSujung YoonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) |
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DOAJ |
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Medicine R Science Q |
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Medicine R Science Q Jungyoon Kim Ilhyang Kang Yong-An Chung Tae-Suk Kim Eun Namgung Suji Lee Jin Kyoung Oh Hyeonseok S. Jeong Hanbyul Cho Myeong Ju Kim Tammy D. Kim Soo Hyun Choi Soo Mee Lim In Kyoon Lyoo Sujung Yoon Altered attentional control over the salience network in complex regional pain syndrome |
| description |
Abstract The degree and salience of pain have been known to be constantly monitored and modulated by the brain. In the case of maladaptive neural responses as reported in centralized pain conditions such as complex regional pain syndrome (CRPS), the perception of pain is amplified and remains elevated even without sustained peripheral pain inputs. Given that the attentional state of the brain greatly influences the perception and interpretation of pain, we investigated the role of the attention network and its dynamic interactions with other pain-related networks of the brain in CRPS. We examined alterations in the intra- and inter-network functional connectivities in 21 individuals with CRPS and 49 controls. CRPS-related reduction in intra-network functional connectivity was found in the attention network. Individuals with CRPS had greater inter-network connectivities between the attention and salience networks as compared with healthy controls. Furthermore, individuals within the CRPS group with high levels of pain catastrophizing showed greater inter-network connectivities between the attention and salience networks. Taken together, the current findings suggest that these altered connectivities may be potentially associated with the maladaptive pain coping as found in CRPS patients. |
| format |
article |
| author |
Jungyoon Kim Ilhyang Kang Yong-An Chung Tae-Suk Kim Eun Namgung Suji Lee Jin Kyoung Oh Hyeonseok S. Jeong Hanbyul Cho Myeong Ju Kim Tammy D. Kim Soo Hyun Choi Soo Mee Lim In Kyoon Lyoo Sujung Yoon |
| author_facet |
Jungyoon Kim Ilhyang Kang Yong-An Chung Tae-Suk Kim Eun Namgung Suji Lee Jin Kyoung Oh Hyeonseok S. Jeong Hanbyul Cho Myeong Ju Kim Tammy D. Kim Soo Hyun Choi Soo Mee Lim In Kyoon Lyoo Sujung Yoon |
| author_sort |
Jungyoon Kim |
| title |
Altered attentional control over the salience network in complex regional pain syndrome |
| title_short |
Altered attentional control over the salience network in complex regional pain syndrome |
| title_full |
Altered attentional control over the salience network in complex regional pain syndrome |
| title_fullStr |
Altered attentional control over the salience network in complex regional pain syndrome |
| title_full_unstemmed |
Altered attentional control over the salience network in complex regional pain syndrome |
| title_sort |
altered attentional control over the salience network in complex regional pain syndrome |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/bc114e7a0d57410487de761eb5e640ce |
| work_keys_str_mv |
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