The Neurobehavioral Phenotype of School-Aged, Very Prematurely Born Children with No Serious Neurological Sequelae: A Quality of Life Predictor
School-aged extremely preterm (EPT) children have multiple specific neurocognitive/behavioral disorders that are often associated with other disorders; this manifests a true neurobehavioral “phenotype” of prematurity. To determine a profile of cognitive/behavioral impairments in a population of scho...
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MDPI AG
2021
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oai:doaj.org-article:bc126970538842dd9428a69e10d147772021-11-25T17:13:47ZThe Neurobehavioral Phenotype of School-Aged, Very Prematurely Born Children with No Serious Neurological Sequelae: A Quality of Life Predictor10.3390/children81109432227-9067https://doaj.org/article/bc126970538842dd9428a69e10d147772021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9067/8/11/943https://doaj.org/toc/2227-9067School-aged extremely preterm (EPT) children have multiple specific neurocognitive/behavioral disorders that are often associated with other disorders; this manifests a true neurobehavioral “phenotype” of prematurity. To determine a profile of cognitive/behavioral impairments in a population of school-aged EPT children (7–10 years-old) without major disabilities, a cross-sectional study was conducted in five medical centers. An algorithm distributed the study population according to four WISC-IV subtests, five NEPSY-2 subtests, and two variables of figure of Rey. The behavior (SDQ), anxiety (Spielberg STAI-C), and generic QoL (Kidscreen 10 and VSP-A) were also evaluated. The study included 231 school-aged EPT children. Three neurobehavioral “phenotypes” were defined according to their severity: 1 = moderately, 2 = minor, and 3 = unimpaired. In all the profiles, the working memory, perceptual reasoning, as well as mental flexibility, were close to or below average, and their emotional behavior was always troubled. Self-esteem and school-work were the most impacted QoL areas. The unimpaired neurobehavior exhibited emotional behavioral impairment and executive dysfunction. The profile analysis defined distinct outcome groups and provided an informative means of identifying factors related to developmental outcomes. The QoL deterioration is determined by the severity of the three neurobehavioral “phenotypes”, which is defined as well as by dysexecutive and/or behavioral disorders.Barthélémy ToselloSahra MézianeNoémie ResseguierStéphane MarretGilles CambonieMeriem ZahedVéronique Brévaut-MalatyAny Beltran AnzolaCatherine Girefor the GPQoL-Study GroupMDPI AGarticleextremely pre-term childrenneurocognitive/behavioral disordersquality of lifeanxietyPediatricsRJ1-570ENChildren, Vol 8, Iss 943, p 943 (2021) |
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| topic |
extremely pre-term children neurocognitive/behavioral disorders quality of life anxiety Pediatrics RJ1-570 |
| spellingShingle |
extremely pre-term children neurocognitive/behavioral disorders quality of life anxiety Pediatrics RJ1-570 Barthélémy Tosello Sahra Méziane Noémie Resseguier Stéphane Marret Gilles Cambonie Meriem Zahed Véronique Brévaut-Malaty Any Beltran Anzola Catherine Gire for the GPQoL-Study Group The Neurobehavioral Phenotype of School-Aged, Very Prematurely Born Children with No Serious Neurological Sequelae: A Quality of Life Predictor |
| description |
School-aged extremely preterm (EPT) children have multiple specific neurocognitive/behavioral disorders that are often associated with other disorders; this manifests a true neurobehavioral “phenotype” of prematurity. To determine a profile of cognitive/behavioral impairments in a population of school-aged EPT children (7–10 years-old) without major disabilities, a cross-sectional study was conducted in five medical centers. An algorithm distributed the study population according to four WISC-IV subtests, five NEPSY-2 subtests, and two variables of figure of Rey. The behavior (SDQ), anxiety (Spielberg STAI-C), and generic QoL (Kidscreen 10 and VSP-A) were also evaluated. The study included 231 school-aged EPT children. Three neurobehavioral “phenotypes” were defined according to their severity: 1 = moderately, 2 = minor, and 3 = unimpaired. In all the profiles, the working memory, perceptual reasoning, as well as mental flexibility, were close to or below average, and their emotional behavior was always troubled. Self-esteem and school-work were the most impacted QoL areas. The unimpaired neurobehavior exhibited emotional behavioral impairment and executive dysfunction. The profile analysis defined distinct outcome groups and provided an informative means of identifying factors related to developmental outcomes. The QoL deterioration is determined by the severity of the three neurobehavioral “phenotypes”, which is defined as well as by dysexecutive and/or behavioral disorders. |
| format |
article |
| author |
Barthélémy Tosello Sahra Méziane Noémie Resseguier Stéphane Marret Gilles Cambonie Meriem Zahed Véronique Brévaut-Malaty Any Beltran Anzola Catherine Gire for the GPQoL-Study Group |
| author_facet |
Barthélémy Tosello Sahra Méziane Noémie Resseguier Stéphane Marret Gilles Cambonie Meriem Zahed Véronique Brévaut-Malaty Any Beltran Anzola Catherine Gire for the GPQoL-Study Group |
| author_sort |
Barthélémy Tosello |
| title |
The Neurobehavioral Phenotype of School-Aged, Very Prematurely Born Children with No Serious Neurological Sequelae: A Quality of Life Predictor |
| title_short |
The Neurobehavioral Phenotype of School-Aged, Very Prematurely Born Children with No Serious Neurological Sequelae: A Quality of Life Predictor |
| title_full |
The Neurobehavioral Phenotype of School-Aged, Very Prematurely Born Children with No Serious Neurological Sequelae: A Quality of Life Predictor |
| title_fullStr |
The Neurobehavioral Phenotype of School-Aged, Very Prematurely Born Children with No Serious Neurological Sequelae: A Quality of Life Predictor |
| title_full_unstemmed |
The Neurobehavioral Phenotype of School-Aged, Very Prematurely Born Children with No Serious Neurological Sequelae: A Quality of Life Predictor |
| title_sort |
neurobehavioral phenotype of school-aged, very prematurely born children with no serious neurological sequelae: a quality of life predictor |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/bc126970538842dd9428a69e10d14777 |
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